AutismKB 2.0

Annotation Detail for SCUBE1


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Basic Information Top
Gene Symbol:SCUBE1 ( - )
Gene Full Name: signal peptide, CUB domain, EGF-like 1
Band: 22q13.2
Quick LinksEntrez ID:80274; OMIM: 611746; Uniprot ID:SCUB1_HUMAN; ENSEMBL ID: ENSG00000159307; HGNC ID: 13441
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
18Phosphothreonine.
370N-linked (GlcNAc...) (Potential).
466N-linked (GlcNAc...) (Potential).
679N-linked (GlcNAc...) (Potential).
750N-linked (GlcNAc...) (Potential).
779N-linked (GlcNAc...) (Potential).
789N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
370N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
466N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
679N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
750N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
779N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
789N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
31Phosphoserine(ATM)HMM predict
180Phosphothreonine(CDC2)HMM predict
308S-palmitoylHMM predict
348S-palmitoylHMM predict
370N-linkedHMM predict
413Phosphothreonine(PKC)HMM predict
466N-linkedHMM predict
468Phosphothreonine(PKA)HMM predict
477Phosphoserine(ATM)HMM predict
477O-linkedHMM predict
482Phosphothreonine(CDK)HMM predict
482Phosphothreonine(MAPK)HMM predict
482Phosphothreonine(CDC2)HMM predict
540Phosphoserine(CDK)HMM predict
540Phosphoserine(CDC2)HMM predict
540Phosphoserine(PKG)HMM predict
584Phosphothreonine(PKC)HMM predict
595Phosphotyrosine(Jak)HMM predict
603Phosphotyrosine(INSR)HMM predict
603Phosphotyrosine(SRC)HMM predict
633S-palmitoylHMM predict
654Phosphotyrosine(SRC)HMM predict
654Phosphotyrosine(INSR)HMM predict
664PhosphothreonineHMM predict
679N-linkedHMM predict
720S-palmitoylHMM predict
744Phosphoserine(ATM)HMM predict
750N-linkedHMM predict
779N-linkedHMM predict
789N-linkedHMM predict
795N-linkedHMM predict
805Phosphotyrosine(INSR)HMM predict
860Phosphoserine(PKG)HMM predict
860Phosphoserine(PKA)HMM predict
862Phosphoserine(CDC2)HMM predict
862Phosphoserine(CDK)HMM predict
867O-linkedHMM predict
868O-linkedHMM predict
914Phosphotyrosine(INSR)HMM predict
914Phosphotyrosine(EGFR)HMM predict
914SulfotyrosineHMM predict
928Phosphotyrosine(INSR)HMM predict
976LeucineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_173050
  • Location:chr22 41929941-42069230
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 42072422 42072776 354 3369
CTCF CD4SISSRdata 42072422 42072776 354 3369
CTCF JurkatGSE12889 42072278 42072658 380 3238
CTCF G2GSE9613 42069115 42069403 288 29
Fos K562GSE19551 42069228 42069688 460 228
H3K27me3 colorectalcancer 42071350 42071868 518 2379
hScc1 CdLSGSE12603 42068840 42069738 898 59
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER MCF7GSE19013 41924354 41925363 1009 5083
Jun K562GSE19551 41922408 41922650 242 7413
TFAP2C MCF7GSE21234 41922458 41922707 249 7359
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 41988290 41991221 2931 0
CBP T30-glioblastomaGSE21026 42001246 42003290 2044 0
CTCF CD4GSE12889 41957220 41957525 305 0
CTCF CD4GSE12889 41999817 42000161 344 0
CTCF CD4SISSRdata 41957220 41957525 305 0
CTCF CD4SISSRdata 41999817 42000161 344 0
CTCF HelaGSE12889 41957154 41957559 405 0
CTCF JurkatGSE12889 41957263 41957582 319 0
CTCF G2GSE9613 41954000 41954792 792 0
CTCF G2GSE9613 41956630 41957653 1023 0
CTCF G2GSE9613 41957956 41958194 238 0
CTCF G2GSE9613 41998688 41999149 461 0
CTCF G2GSE9613 41999835 42000140 305 0
FOXA1 MCF7GSE15244 42019404 42020202 798 0
FOXA1 MCF7GSE15244 42041582 42042041 459 0
Fos K562GSE19551 42001420 42001875 455 0
FoxA1 MCF7MACSdata 42019927 42020085 158 0
GABP k562GSE8489 42048245 42048561 316 0
P300 T0-glioblastomaGSE21026 41989549 41990285 736 0
P300 T30-glioblastomaGSE21026 42001156 42003231 2075 0
P300 T30-glioblastomaGSE21026 42017815 42020712 2897 0
RARA MCF7GSE15244 41989122 41989911 789 0
RARG MCF7GSE15244 41989053 41989911 858 0
TFAP2C MCF7GSE21234 41948225 41948776 551 0
TFAP2C MCF7GSE21234 41979737 41980362 625 0
TFAP2C MCF7GSE21234 42000757 42001351 594 0
TFAP2C MCF7GSE21234 42019276 42019528 252 0
USF1 HepG2E 41961387 41962166 779 0
USF1 HepG2E 41966861 41967608 747 0
VDR GM10855-stimGSE22484 41993084 41994143 1059 0
VDR GM10855-stimGSE22484 41996004 41997931 1927 0
VDR GM10861-stimGSE22484 41996097 41997862 1765 0
hScc1 BcellGSE12603 41931144 41931385 241 0
hScc1 BcellGSE12603 41943225 41943700 475 0
hScc1 BcellGSE12603 41953026 41953656 630 0
hScc1 BcellGSE12603 41953928 41954930 1002 0
hScc1 BcellGSE12603 41956957 41958167 1210 0
hScc1 BcellGSE12603 41970826 41971818 992 0
hScc1 BcellGSE12603 41972882 41973103 221 0
hScc1 BcellGSE12603 41976173 41976724 551 0
hScc1 BcellGSE12603 41978029 41978504 475 0
hScc1 BcellGSE12603 41992674 41993429 755 0
hScc1 BcellGSE12603 41999835 42000574 739 0
hScc1 BcellGSE12603 42014215 42014614 399 0
hScc1 BcellGSE12603 42015827 42016497 670 0
hScc1 BcellGSE12603 42021265 42021945 680 0
hScc1 BcellGSE12603 42038726 42039101 375 0
hScc1 BcellGSE12603 42050568 42050754 186 0
hScc1 BcellGSE12603 42067868 42069738 1870 0
hScc1 CdLSGSE12603 41954281 41954865 584 0
hScc1 CdLSGSE12603 41956992 41957653 661 0
hScc1 CdLSGSE12603 41999835 42000140 305 0
hScc1 G2GSE9613 41954000 41954792 792 0
hScc1 G2GSE9613 41956630 41957653 1023 0
hScc1 G2GSE9613 41999835 42000140 305 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
17562 EST chr22 41952644 41959514 117 mRNA SCUBE1 chr22 41924495 42063785Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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