AutismKB 2.0

Annotation Detail for CUBN


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Basic Information Top
Gene Symbol:CUBN ( FLJ90055,FLJ90747,IFCR,MGA1,gp280 )
Gene Full Name: cubilin (intrinsic factor-cobalamin receptor)
Band: 10p13
Quick LinksEntrez ID:8029; OMIM: 602997; Uniprot ID:CUBN_HUMAN; ENSEMBL ID: ENSG00000107611; HGNC ID: 2548
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
3N-linked (GlcNAc...) (Potential).
105N-linked (GlcNAc...) (Potential).
428N-linked (GlcNAc...) (Potential).
482N-linked (GlcNAc...) (Potential).
711N-linked (GlcNAc...) (Potential).
749N-linked (GlcNAc...) (Potential).
781N-linked (GlcNAc...) (Potential).
857N-linked (GlcNAc...) (Potential).
957N-linked (GlcNAc...) (Potential).
984N-linked (GlcNAc...).
1092N-linked (GlcNAc...).
1168N-linked (GlcNAc...).
1217N-linked (GlcNAc...).
1285N-linked (GlcNAc...).
1307N-linked (GlcNAc...).
1319N-linked (GlcNAc...).
1332N-linked (GlcNAc...).
1500N-linked (GlcNAc...) (Potential).
1551N-linked (GlcNAc...) (Potential).
1646N-linked (GlcNAc...) (Potential).
1802N-linked (GlcNAc...) (Potential).
1819N-linked (GlcNAc...) (Potential).
1885N-linked (GlcNAc...) (Potential).
2085N-linked (GlcNAc...) (Potential).
2117N-linked (GlcNAc...) (Potential).
2274N-linked (GlcNAc...) (Potential).
2386N-linked (GlcNAc...) (Potential).
2400N-linked (GlcNAc...) (Potential).
2531N-linked (GlcNAc...) (Potential).
2581N-linked (GlcNAc...) (Potential).
2592N-linked (GlcNAc...) (Potential).
2610N-linked (GlcNAc...) (Potential).
2813N-linked (GlcNAc...) (Potential).
2923N-linked (GlcNAc...) (Potential).
2945N-linked (GlcNAc...) (Potential).
3042N-linked (GlcNAc...) (Potential).
3103N-linked (GlcNAc...) (Potential).
3125N-linked (GlcNAc...) (Potential).
3165N-linked (GlcNAc...) (Potential).
3268N-linked (GlcNAc...) (Potential).
3283N-linked (GlcNAc...) (Potential).
3290N-linked (GlcNAc...) (Potential).
3295N-linked (GlcNAc...) (Potential).
3357N-linked (GlcNAc...) (Potential).
3430N-linked (GlcNAc...) (Potential).
3457N-linked (GlcNAc...) (Potential).
3533N-linked (GlcNAc...) (Potential).
3576N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
3N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
105N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
428N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
482N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
711N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
749N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
781N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
857N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
957N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
984N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1092N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1168N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1217N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1285N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1307N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1319N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1332N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1500N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1551N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1646N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1802N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1819N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1885N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2085N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2117N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2274N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2386N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2400N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2531N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2581N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2592N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2610N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2813N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2923N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
2945N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3042N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3103N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3125N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3165N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3268N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3283N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3290N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3295N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3357N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3430N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3457N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3533N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
3576N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
79Phosphoserine(CK2)HMM predict
130Phosphothreonine(PKC)HMM predict
158S-palmitoylHMM predict
257Phosphoserine(CDC2)HMM predict
257Phosphoserine(IKK)HMM predict
301Phosphotyrosine(INSR)HMM predict
368Phosphoserine(CK1)HMM predict
368Phosphoserine(IKK)HMM predict
369O-linkedHMM predict
372O-linkedHMM predict
387Phosphotyrosine(INSR)HMM predict
428N-linkedHMM predict
432N-linkedHMM predict
434N-linkedHMM predict
482N-linkedHMM predict
494Phosphotyrosine(Jak)HMM predict
559Phosphoserine(CK1)HMM predict
580Phosphothreonine(PKC)HMM predict
606Phosphotyrosine(INSR)HMM predict
711N-linkedHMM predict
712Phosphotyrosine(INSR)HMM predict
712Phosphotyrosine(Abl)HMM predict
713Phosphothreonine(INSR)HMM predict
749N-linkedHMM predict
762Phosphoserine(ATM)HMM predict
765Phosphotyrosine(EGFR)HMM predict
765Phosphotyrosine(INSR)HMM predict
781N-linkedHMM predict
789O-linkedHMM predict
829Phosphoserine(CDC2)HMM predict
851Phosphoserine(ATM)HMM predict
857N-linkedHMM predict
884Phosphoserine(CDC2)HMM predict
915Phosphoserine(CK1)HMM predict
957N-linkedHMM predict
984N-linkedHMM predict
987N-linkedHMM predict
989Phosphotyrosine(Syk)HMM predict
1000Phosphoserine(CK1)HMM predict
1012O-linkedHMM predict
1014O-linkedHMM predict
1061Phosphoserine(CDC2)HMM predict
1114Phosphotyrosine(EGFR)HMM predict
1168N-linkedHMM predict
1173O-linkedHMM predict
1175O-linkedHMM predict
1217N-linkedHMM predict
1285N-linkedHMM predict
1296Phosphotyrosine(INSR)HMM predict
1307N-linkedHMM predict
1319N-linkedHMM predict
1362O-linkedHMM predict
1401Phosphoserine(IKK)HMM predict
1404O-linkedHMM predict
1404Phosphoserine(CDC2)HMM predict
1500N-linkedHMM predict
1526Phosphotyrosine(EGFR)HMM predict
1526Phosphotyrosine(INSR)HMM predict
1528Phosphoserine(CDC2)HMM predict
1528Phosphoserine(CDK)HMM predict
1551N-linkedHMM predict
1634Phosphoserine(CDC2)HMM predict
1634Phosphoserine(CDK)HMM predict
1713Phosphothreonine(PKC)HMM predict
1729O-linkedHMM predict
1730O-linkedHMM predict
1730O-linkedHMM predict
1734Phosphoserine(IKK)HMM predict
1754Phosphotyrosine(EGFR)HMM predict
1754Phosphotyrosine(INSR)HMM predict
1754SulfotyrosineHMM predict
1758SulfotyrosineHMM predict
1771Phosphoserine(CDC2)HMM predict
1788Phosphoserine(ATM)HMM predict
1802N-linkedHMM predict
1819N-linkedHMM predict
1837Phosphoserine(IKK)HMM predict
1885N-linkedHMM predict
1913Phosphotyrosine(INSR)HMM predict
1933O-linkedHMM predict
1933Phosphoserine(IKK)HMM predict
1935Phosphoserine(CK1)HMM predict
2068Phosphotyrosine(SRC)HMM predict
2074Phosphothreonine(PKA)HMM predict
2085N-linkedHMM predict
2095Phosphotyrosine(Jak)HMM predict
2117N-linkedHMM predict
2200Phosphoserine(IKK)HMM predict
2231Phosphotyrosine(Jak)HMM predict
2274N-linkedHMM predict
2278N-linkedHMM predict
2304Phosphoserine(ATM)HMM predict
2313Phosphotyrosine(EGFR)HMM predict
2386N-linkedHMM predict
2400N-linkedHMM predict
2405N-linkedHMM predict
2418O-linkedHMM predict
2468Phosphotyrosine(INSR)HMM predict
2491Phosphothreonine(PKA)HMM predict
2563O-linkedHMM predict
2564O-linkedHMM predict
2577Phosphothreonine(CDC2)HMM predict
2581N-linkedHMM predict
2587Phosphotyrosine(Jak)HMM predict
2705Phosphotyrosine(INSR)HMM predict
2709Phosphotyrosine(Syk)HMM predict
2754Phosphoserine(CDC2)HMM predict
2813N-linkedHMM predict
2893O-linkedHMM predict
2893O-linkedHMM predict
2895O-linkedHMM predict
2897O-linkedHMM predict
2904Phosphoserine(IKK)HMM predict
2923N-linkedHMM predict
2945N-linkedHMM predict
3053Phosphotyrosine(SRC)HMM predict
3058SulfotyrosineHMM predict
3103N-linkedHMM predict
3165N-linkedHMM predict
3166N-linkedHMM predict
3170Phosphoserine(CDC2)HMM predict
3170Phosphoserine(MAPK)HMM predict
3235PhosphothreonineHMM predict
3268N-linkedHMM predict
3283N-linkedHMM predict
3290N-linkedHMM predict
3293Phosphoserine(CDC2)HMM predict
3293Phosphoserine(ATM)HMM predict
3295N-linkedHMM predict
3297Phosphoserine(CK1)HMM predict
3357N-linkedHMM predict
3430N-linkedHMM predict
3457N-linkedHMM predict
3460N-linkedHMM predict
3462N-linkedHMM predict
3493Phosphoserine(IKK)HMM predict
3507Phosphoserine(CDK)HMM predict
3521Phosphoserine(IKK)HMM predict
3533N-linkedHMM predict
3534N-linkedHMM predict
3550Phosphothreonine(PKC)HMM predict
3572Phosphotyrosine(INSR)HMM predict
3576N-linkedHMM predict
3579Phosphoserine(CDC2)HMM predict
3579Phosphoserine(CDK)HMM predict
3581O-linkedHMM predict
3585Phosphotyrosine(Jak)HMM predict
3615PhosphoserineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001081
  • Location:chr10 16906543-17211795
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 H2O2-HelaGSE14283 17214091 17214120 29 2310
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 17157291 17158174 883 0
CTCF CD4GSE12889 16925318 16925651 333 0
CTCF CD4SISSRdata 16925318 16925651 333 0
ER E2-MCF7GSE14664 16943340 16943388 48 0
ER E2-MCF7GSE14664 16969632 16969720 88 0
ER Fulvestrant-MCF7GSE14664 17054546 17054587 41 0
ER Fulvestrant-MCF7GSE14664 17135588 17135624 36 0
ER Fulvestrant-MCF7GSE14664 17145204 17145248 44 0
Fos K562GSE19551 17111378 17112146 768 0
FoxA1 MCF7MACSdata 16975648 16975933 285 0
Gata2 K562GSE18868 17084995 17085565 570 0
Myc K562GSE19551 17085104 17085609 505 0
NRSF JurkatGSE13047 16906776 16907051 275 0
NRSF JurkatSISSRdata 16906863 16907051 188 0
NRSF JurkatSISSRdata 17196030 17196206 176 0
NRSF mAbJurkat 16906839 16907482 643 0
NRSF-mono JurkatQuESTdata 16906801 16907050 249 0
NRSF-poly JurkatQuESTdata 16906776 16907093 317 0
Nanog ESGSE20650 16983094 16983634 540 0
Nanog ESGSE20650 17011030 17011528 498 0
Nanog hESGSE18292 16983127 16983568 441 0
Nanog hESGSE18292 17010881 17011422 541 0
Nanog hESGSE18292 17103710 17104145 435 0
Oct1 H2O2-HelaGSE14283 16921150 16921179 29 0
Oct1 H2O2-HelaGSE14283 16980553 16980593 40 0
Oct1 H2O2-HelaGSE14283 17080372 17080405 33 0
Oct1 H2O2-HelaGSE14283 17200825 17200852 27 0
Oct1 HelaGSE14283 16912611 16912648 37 0
Oct1 HelaGSE14283 16969632 16969688 56 0
Oct1 HelaGSE14283 16980549 16980591 42 0
Oct1 HelaGSE14283 17051269 17051305 36 0
Oct1 HelaGSE14283 17080372 17080405 33 0
Oct1 HelaGSE14283 17111793 17111824 31 0
Oct1 HelaGSE14283 17118021 17118062 41 0
Oct1 HelaGSE14283 17135582 17135630 48 0
Oct1 HelaGSE14283 17139456 17139498 42 0
Oct4 ESGSE20650 16983149 16983539 390 0
Oct4 hESGSE21916 16983139 16983495 356 0
P300 T0-glioblastomaGSE21026 17105320 17106060 740 0
P300 T30-glioblastomaGSE21026 17083858 17085732 1874 0
P300 T30-glioblastomaGSE21026 17105060 17106162 1102 0
P300 T30-glioblastomaGSE21026 17157246 17158266 1020 0
P300 T30-glioblastomaGSE21026 17170060 17171024 964 0
P300 T30-glioblastomaGSE21026 17204841 17206059 1218 0
PolII HeLaGSE12783 16973620 16974604 984 0
RARA MCF7GSE15244 17197582 17198084 502 0
RARG MCF7GSE15244 16910740 16911661 921 0
RARG MCF7GSE15244 17197285 17198047 762 0
STAT1 HeLaGSE12782 17111373 17112147 774 0
STAT1 HeLaGSE12783 17111407 17112113 706 0
STAT1 IFNSISSRdata 17111340 17112011 671 0
Sox2 hESGSE18292 16925387 16925565 178 0
Sox2 hESGSE18292 16983202 16983552 350 0
Stat6 IL-4-hr1GSE17850 17044258 17045257 999 0
hScc1 BcellGSE12603 16910055 16910360 305 0
hScc1 BcellGSE12603 16925183 16925728 545 0
hScc1 BcellGSE12603 16935311 16935601 290 0
hScc1 BcellGSE12603 17071877 17072144 267 0
hScc1 CdLSGSE12603 16925111 16925930 819 0
hScc1 CdLSGSE12603 16935243 16935744 501 0
p130 SenescentGSE19898 17077849 17078201 352 0
p130 shRbQuiescentGSE19898 17049513 17050809 1296 0
p130 shRbQuiescentGSE19898 17107724 17108472 748 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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