AutismKB 2.0

Annotation Detail for SLC7A5


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Basic Information Top
Gene Symbol:SLC7A5 ( 4F2LC,CD98,D16S469E,E16,LAT1,MPE16,hLAT1 )
Gene Full Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
Band: 16q24.2
Quick LinksEntrez ID:8140; OMIM: 600182; Uniprot ID:LAT1_HUMAN; ENSEMBL ID: ENSG00000103257; HGNC ID: 11063
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
31Phosphoserine.
35Phosphoserine.
49N-linked (GlcNAc...) (Potential).
230N-linked (GlcNAc...) (Potential).
340N-linked (GlcNAc...) (Potential).
507Phosphothreonine.
Location(AA) Modifications Resource
35Phosphoserine.Swiss-Prot 53.0
35PhosphoserinePhospho.ELM 6.0
49N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
230N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
340N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
507Phosphothreonine.Swiss-Prot 53.0
507PhosphothreoninePhospho.ELM 6.0
Location(AA) Modification Resource
49N-linkedHMM predict
54N-linkedHMM predict
96O-linkedHMM predict
117Phosphotyrosine(INSR)HMM predict
119Phosphotyrosine(INSR)HMM predict
230N-linkedHMM predict
340N-linkedHMM predict
372Phosphothreonine(MAPK)HMM predict
489IsoleucineHMM predict
503ValineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003486
  • Location:chr16 86421130-86460600
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 86462655 86462985 330 2220
CTCF CD4GSE12889 86469071 86469221 150 8546
CTCF CD4SISSRdata 86462655 86462985 330 2220
CTCF CD4SISSRdata 86469071 86469221 150 8546
CTCF JurkatGSE12889 86462754 86462966 212 2260
CTCF G2GSE9613 86462078 86462940 862 1909
CTCF G2GSE9613 86469276 86469467 191 8771
FOXA1 MCF7GSE15244 86461104 86462006 902 955
Fos K562GSE19551 86466260 86466704 444 5882
H3ac HepG2E 86461146 86461750 604 848
Rb QuiescentGSE19898 86462739 86462847 108 2193
TAF HelaGSE8489 86461345 86461714 369 929
hScc1 BcellGSE12603 86462483 86462940 457 2111
hScc1 BcellGSE12603 86469276 86469820 544 8948
hScc1 CdLSGSE12603 86462377 86462940 563 2058
hScc1 G2GSE9613 86461970 86462940 970 1855
p130 shRbQuiescentGSE19898 86461636 86462155 519 1295
p130 shRbQuiescentGSE19898 86462455 86462944 489 2099
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER MCF7GSE19013 86419204 86419622 418 1718
NFkBII GM10847GSE19485 86400051 86402285 2234 19963
hScc1 BcellGSE12603 86401261 86401525 264 19738
p63 keratinocytesGSE17611 86413804 86414942 1138 6758
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 86432736 86434905 2169 0
CTCF CD4GSE12889 86441150 86441469 319 0
CTCF CD4SISSRdata 86441150 86441469 319 0
CTCF G2GSE9613 86425466 86426372 906 0
CTCF G2GSE9613 86432778 86433254 476 0
CTCF G2GSE9613 86437760 86438644 884 0
CTCF G2GSE9613 86440701 86441778 1077 0
CTCF G2GSE9613 86442203 86443192 989 0
CTCF G2GSE9613 86445744 86446485 741 0
CTCF G2GSE9613 86447008 86447215 207 0
CTCF G2GSE9613 86459836 86461018 1182 0
ER MCF7GSE19013 86425452 86426464 1012 0
FOXA1 MCF7GSE15244 86451799 86452128 329 0
Gata1 K562GSE18868 86445477 86446149 672 0
Gata2 K562GSE18868 86445286 86446287 1001 0
Gata2 K562GSE18868 86460122 86460685 563 0
H3K4me2 HCT116GSE10453 86458341 86458886 545 0
H3K4me2 HCT116GSE10453 86459267 86460045 778 0
H3K4me3 colorectalcancer 86459543 86460368 825 0
H3ac HepG2E 86453412 86455066 1654 0
H3ac HepG2E 86456188 86456508 320 0
H3ac HepG2E 86456921 86457405 484 0
H3ac HepG2E 86458341 86458886 545 0
H3ac HepG2E 86459267 86460257 990 0
KLF4 hESGSE17917 86445165 86445337 172 0
Nanog ESGSE20650 86455561 86456148 587 0
PHF8 HeLaGSE20725 86459922 86460999 1077 0
RARA MCF7GSE15244 86425224 86426253 1029 0
RARA MCF7GSE15244 86444153 86444960 807 0
RARA MCF7GSE15244 86445269 86445744 475 0
RARA MCF7GSE15244 86451799 86452164 365 0
RARA MCF7GSE15244 86452454 86453449 995 0
RARA MCF7GSE15244 86456188 86456508 320 0
RARA MCF7GSE15244 86458341 86458886 545 0
TAF HelaGSE8489 86459267 86460404 1137 0
TAF k562GSE8489 86459267 86460334 1067 0
TFAP2C MCF7GSE21234 86425122 86426702 1580 0
TFAP2C MCF7GSE21234 86440898 86441628 730 0
TFAP2C MCF7GSE21234 86444400 86446310 1910 0
TFAP2C MCF7GSE21234 86451312 86452165 853 0
TFAP2C MCF7GSE21234 86457769 86458991 1222 0
USF1 HepG2E 86451905 86455066 3161 0
USF2 HepG2E 86452023 86453033 1010 0
hScc1 BcellGSE12603 86426920 86427407 487 0
hScc1 BcellGSE12603 86440959 86442203 1244 0
hScc1 BcellGSE12603 86457182 86457405 223 0
hScc1 BcellGSE12603 86459267 86459579 312 0
hScc1 BcellGSE12603 86459836 86461146 1310 0
hScc1 CdLSGSE12603 86440996 86441824 828 0
hScc1 CdLSGSE12603 86459689 86461064 1375 0
p130 SenescentGSE19898 86444915 86445180 265 0
p130 shRbSenescentGSE19898 86444394 86444774 380 0
p130 shRbSenescentGSE19898 86444948 86445158 210 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-140-3p hsa-mir-140 16 20467336
hsa-miR-140-5p hsa-mir-140 16 20467336
hsa-miR-182 hsa-mir-182 7 20467336
hsa-miR-182* hsa-mir-182 7 20467336
hsa-miR-194 hsa-mir-194-1 1 20467336
hsa-miR-194 hsa-mir-194-2 11 20467336
hsa-miR-200c hsa-mir-200c 12 20467336
hsa-miR-200c* hsa-mir-200c 12 20467336
hsa-miR-29b hsa-mir-29b-1 7 20543536
hsa-miR-29b hsa-mir-29b-2 1 20543536
hsa-miR-29c hsa-mir-29c 1 20543536
hsa-miR-29c* hsa-mir-29c 1 20543536
hsa-miR-9 hsa-mir-9-1 1 21368052
hsa-miR-9 hsa-mir-9-2 5 21368052
hsa-miR-9 hsa-mir-9-3 15 21368052
hsa-miR-9* hsa-mir-9-2 5 21368052
hsa-miR-9* hsa-mir-9-3 15 21368052
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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