AutismKB 2.0

Annotation Detail for DOCK8


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:DOCK8 ( FLJ00026,FLJ00152,FLJ00346,MRD2,ZIR8 )
Gene Full Name: dedicator of cytokinesis 8
Band: 9p24.3
Quick LinksEntrez ID:81704; OMIM: 611432; Uniprot ID:DOCK8_HUMAN; ENSEMBL ID: ENSG00000107099; HGNC ID: 19191
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
451Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
206Phosphothreonine(PKC)HMM predict
263O-linkedHMM predict
267O-linkedHMM predict
269O-linkedHMM predict
276Phosphotyrosine(Syk)HMM predict
276Phosphotyrosine(Jak)HMM predict
378Phosphoserine(CAMK2)HMM predict
378Phosphoserine(PKG)HMM predict
378Phosphoserine(PKA)HMM predict
383Phosphoserine(CK1)HMM predict
383Phosphoserine(PKG)HMM predict
395O-linkedHMM predict
396O-linkedHMM predict
468N-linkedHMM predict
547Phosphotyrosine(Syk)HMM predict
554N-linkedHMM predict
560Phosphotyrosine(Syk)HMM predict
560Phosphotyrosine(SRC)HMM predict
680Phosphoserine(IKK)HMM predict
680Phosphoserine(CK1)HMM predict
683Phosphoserine(ATM)HMM predict
713N-linkedHMM predict
747N-linkedHMM predict
749Phosphoserine(ATM)HMM predict
770Phosphoserine(CK1)HMM predict
818O-linkedHMM predict
819O-linkedHMM predict
834Phosphoserine(CK1)HMM predict
863N-linkedHMM predict
872Phosphoserine(ATM)HMM predict
879Phosphoserine(CK1)HMM predict
879O-linkedHMM predict
880PhosphoserineHMM predict
880Phosphoserine(IKK)HMM predict
880Phosphoserine(CDK)HMM predict
880Phosphoserine(MAPK)HMM predict
880Phosphoserine(CDC2)HMM predict
880O-linkedHMM predict
1016Phosphoserine(PKG)HMM predict
1054Phosphoserine(IKK)HMM predict
1058Phosphoserine(CK1)HMM predict
1058O-linkedHMM predict
1063N-linkedHMM predict
1069Phosphoserine(IKK)HMM predict
1126Phosphoserine(CK1)HMM predict
1174Phosphothreonine(PKA)HMM predict
1177Phosphoserine(CK2)HMM predict
1177PhosphoserineHMM predict
1266S-palmitoylHMM predict
1282O-linkedHMM predict
1616Phosphotyrosine(Syk)HMM predict
1643Phosphoserine(ATM)HMM predict
1643Phosphoserine(CK2)HMM predict
1643Phosphoserine(MAPK)HMM predict
1701Phosphothreonine(PKC)HMM predict
1701Phosphothreonine(PKA)HMM predict
1781Phosphothreonine(CDC2)HMM predict
1807Phosphotyrosine(Syk)HMM predict
1974SulfotyrosineHMM predict
2023S-farnesylHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_203447
  • Location:chr9 263047-455251
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 262049 262512 463 767
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 459162 460731 1569 4695
H3ac HepG2E 460046 460617 571 5080
HIF1 HypoHepG2 459895 460653 758 5023
HIF1 NormHepG2 459852 460463 611 4906
Nanog hESGSE18292 467062 467802 740 12181
PHF8 293TGSE20725 459944 460544 600 4993
PHF8 HeLaGSE20725 459692 460874 1182 5032
Sox2 hESGSE18292 467264 467566 302 12164
p130 QuiescentGSE19898 459719 460074 355 4645
p63 keratinocytesGSE17611 459970 461206 1236 5337
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 297044 297257 213 0
CTCF CD4SISSRdata 297044 297257 213 0
CTCF JurkatGSE12889 375904 376158 254 0
FOXA1 MCF7GSE15244 325610 326781 1171 0
FOXA1 MCF7GSE15244 409506 410319 813 0
FoxA1 MCF7MACSdata 325952 326379 427 0
FoxA1 MCF7MACSdata 409586 410053 467 0
Gata2 K562GSE18868 347613 347947 334 0
HIF1 NormHepG2 378362 378528 166 0
Myc K562GSE19551 347584 347853 269 0
Nanog ESGSE20650 321138 321708 570 0
Nanog ESGSE20650 434504 434987 483 0
Nanog hESGSE18292 360957 361328 371 0
P300 T0-glioblastomaGSE21026 325902 326632 730 0
RARA MCF7GSE15244 325610 326781 1171 0
RARA MCF7GSE15244 408577 410458 1881 0
TAF k562GSE8489 262698 263650 952 0
TAF k562GSE8489 264005 265401 1396 0
TFAP2C MCF7GSE21234 287491 287960 469 0
TFAP2C MCF7GSE21234 294125 294560 435 0
TFAP2C MCF7GSE21234 325944 326706 762 0
hScc1 BcellGSE12603 310283 312394 2111 0
hScc1 G2GSE9613 337536 338276 740 0
hScc1 G2GSE9613 375848 376560 712 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
26145 mRNA DOCK8 chr9 263047 455252 77 EST chr9 455175 459777Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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