AutismKB 2.0

Annotation Detail for NCOA3


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Basic Information Top
Gene Symbol:NCOA3 ( ACTR,AIB-1,AIB1,CAGH16,CTG26,KAT13B,MGC141848,RAC3,SRC-3,SRC3,TNRC14,TNRC16,TRAM-1,bHLHe42,pCIP )
Gene Full Name: nuclear receptor coactivator 3
Band: 20q13.12
Quick LinksEntrez ID:8202; OMIM: 601937; Uniprot ID:NCOA3_HUMAN; ENSEMBL ID: ENSG00000124151; HGNC ID: 7670
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
214Phosphoserine.
551Phosphoserine.
616N6-acetyllysine; by CREBBP.
619N6-acetyllysine; by CREBBP.
620N6-acetyllysine; by CREBBP.
687N6-acetyllysine.
689LXXLL motif 1.
728Phosphoserine.
742LXXLL motif 2.
857Phosphoserine.
867Phosphoserine.
1042Phosphoserine (By similarity).
1061LXXLL motif 3.
Location(AA) Modifications Resource
24PhosphothreoninePhospho.ELM 6.0
505PhosphoserinePhospho.ELM 6.0
543PhosphoserinePhospho.ELM 6.0
616N6-acetyllysine (by CREBBP).Swiss-Prot 53.0
619N6-acetyllysine (by CREBBP).Swiss-Prot 53.0
620N6-acetyllysine (by CREBBP).Swiss-Prot 53.0
857PhosphoserinePhospho.ELM 6.0
857Phosphoserine.Swiss-Prot 53.0
860PhosphoserinePhospho.ELM 6.0
867Phosphoserine.Swiss-Prot 53.0
867PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
44Phosphotyrosine(EGFR)HMM predict
55N-linkedHMM predict
61N-linkedHMM predict
90Phosphoserine(CK2)HMM predict
102O-linkedHMM predict
102Phosphoserine(CK1)HMM predict
140N-linkedHMM predict
154N-linkedHMM predict
159N-linkedHMM predict
185N-linkedHMM predict
221SulfotyrosineHMM predict
314Phosphoserine(ATM)HMM predict
319Phosphotyrosine(EGFR)HMM predict
330Phosphothreonine(CDK)HMM predict
376Phosphotyrosine(Syk)HMM predict
414O-linkedHMM predict
443Phosphothreonine(MAPK)HMM predict
462N-linkedHMM predict
465Phosphoserine(ATM)HMM predict
483Phosphoserine(CDC2)HMM predict
489Phosphoserine(CDC2)HMM predict
515N-linkedHMM predict
517Phosphoserine(IKK)HMM predict
519O-linkedHMM predict
519O-linkedHMM predict
519Phosphoserine(CK1)HMM predict
524Phosphoserine(CK1)HMM predict
536Phosphoserine(IKK)HMM predict
542Phosphoserine(CK1)HMM predict
543Phosphoserine(CDC2)HMM predict
543Phosphoserine(MAPK)HMM predict
543Phosphoserine(CDK)HMM predict
555N-linkedHMM predict
583Phosphoserine(IKK)HMM predict
594Phosphoserine(ATM)HMM predict
598Phosphoserine(CK1)HMM predict
598Phosphoserine(IKK)HMM predict
601Phosphoserine(PKG)HMM predict
601Phosphoserine(CK1)HMM predict
602Phosphoserine(CK1)HMM predict
640Phosphoserine(CDC2)HMM predict
640Phosphoserine(IKK)HMM predict
645Phosphoserine(IKK)HMM predict
652O-linkedHMM predict
652Phosphoserine(IKK)HMM predict
654O-linkedHMM predict
655Phosphoserine(CDC2)HMM predict
655Phosphoserine(MAPK)HMM predict
657O-linkedHMM predict
663O-linkedHMM predict
664O-linkedHMM predict
664O-linkedHMM predict
669O-linkedHMM predict
694Phosphoserine(CDC2)HMM predict
712Phosphoserine(IKK)HMM predict
728Phosphoserine(CDC2)HMM predict
752Phosphoserine(CK1)HMM predict
771Phosphoserine(CDC2)HMM predict
771Phosphoserine(IKK)HMM predict
777Phosphoserine(CDK)HMM predict
778Phosphoserine(ATM)HMM predict
790Phosphoserine(CK1)HMM predict
790Phosphoserine(CK2)HMM predict
820N-linkedHMM predict
842Phosphoserine(ATM)HMM predict
844Phosphoserine(CK2)HMM predict
844Phosphoserine(ATM)HMM predict
863O-linkedHMM predict
867Phosphoserine(CDC2)HMM predict
867Phosphoserine(ATM)HMM predict
898SulfotyrosineHMM predict
908N-linkedHMM predict
912O-linkedHMM predict
914Phosphothreonine(MAPK)HMM predict
914Phosphothreonine(CDK)HMM predict
946N-linkedHMM predict
998Phosphotyrosine(Abl)HMM predict
1132Phosphoserine(CDC2)HMM predict
1134Phosphoserine(IKK)HMM predict
1166Phosphothreonine(MAPK)HMM predict
1166Phosphothreonine(CDK)HMM predict
1185N-linkedHMM predict
1197N-linkedHMM predict
1281O-linkedHMM predict
1281Phosphoserine(CDC2)HMM predict
1281Phosphoserine(ATM)HMM predict
1285N-linkedHMM predict
1287O-linkedHMM predict
1287O-linkedHMM predict
1289O-linkedHMM predict
1315SulfotyrosineHMM predict
1329Phosphoserine(PKG)HMM predict
1337O-linkedHMM predict
1343Phosphoserine(ATM)HMM predict
1357Phosphotyrosine(EGFR)HMM predict
1373N-linkedHMM predict
1375Phosphoserine(CAMK2)HMM predict
1375Phosphoserine(IKK)HMM predict
1375Phosphoserine(PKB)HMM predict
1377Phosphoserine(ATM)HMM predict
1390Phosphotyrosine(Abl)HMM predict
1396N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_006534
  • Location:chr20 45564063-45719018
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 45563793 45564175 382 80
ETS1 JurkatGSE17954 45563384 45564559 1175 92
Fos K562GSE19551 45549303 45549728 425 14548
H3ac HepG2E 45562585 45563118 533 1212
NFkBII GM12878GSE19485 45548788 45550507 1719 14416
PHF8 HeLaGSE20725 45563366 45564468 1102 147
Pol2 GM12878GSE19551 45563271 45564416 1145 220
RARA MCF7GSE15244 45549674 45550077 403 14188
RARA MCF7GSE15244 45555248 45555955 707 8462
RARA MCF7GSE15244 45562544 45563118 574 1233
Stat6 IL-4-hr1GSE17850 45549079 45550069 990 14490
TAF HelaGSE8489 45562544 45563118 574 1233
hScc1 CdLSGSE12603 45563793 45564270 477 32
p63 keratinocytesGSE17611 45543651 45544673 1022 19902
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 45629862 45630982 1120 0
CTCF CD4GSE12889 45683370 45683679 309 0
CTCF CD4SISSRdata 45683370 45683679 309 0
FOXA1 MCF7GSE15244 45704360 45705037 677 0
FOXA1 eGFPGSE10845 45704393 45705037 644 0
Fos K562GSE19551 45603171 45603500 329 0
Fos K562GSE19551 45638635 45639273 638 0
Fos K562GSE19551 45672622 45673055 433 0
FoxA1 MCF7MACSdata 45661828 45662280 452 0
FoxA1 MCF7MACSdata 45704295 45705100 805 0
H3K4me3 colorectalcancer 45564703 45564949 246 0
H3ac HepG2E 45564144 45566019 1875 0
H3ac HepG2E 45568760 45569658 898 0
KLF4 hESGSE17917 45564073 45564349 276 0
Myc K562GSE19551 45586524 45586806 282 0
Myc K562GSE19551 45603271 45603453 182 0
Nanog ESGSE20650 45619977 45620378 401 0
Oct4 hESGSE17917 45648996 45649368 372 0
P300 T0-glioblastomaGSE21026 45629859 45630988 1129 0
P300 T30-glioblastomaGSE21026 45629666 45631090 1424 0
PHF8 293TGSE20725 45563446 45564688 1242 0
RARA MCF7GSE15244 45564766 45566091 1325 0
RARA MCF7GSE15244 45568260 45569470 1210 0
RARA MCF7GSE15244 45602757 45603446 689 0
RARA MCF7GSE15244 45630167 45630482 315 0
RARA MCF7GSE15244 45637746 45639898 2152 0
RARA MCF7GSE15244 45661720 45662236 516 0
Sox2 hESGSE18292 45648791 45649394 603 0
TAF HelaGSE8489 45563793 45565616 1823 0
hScc1 BcellGSE12603 45563793 45564730 937 0
hScc1 CdLSGSE12603 45683124 45683777 653 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 19528081
hsa-let-7a hsa-let-7a-2 11 19528081
hsa-let-7a hsa-let-7a-3 22 19528081
hsa-let-7a hsa-let-7a-1 9 19528081
hsa-let-7a hsa-let-7a-2 11 19528081
hsa-let-7a hsa-let-7a-3 22 19528081
hsa-let-7a* hsa-let-7a-1 9 19528081
hsa-let-7a* hsa-let-7a-3 22 19528081
hsa-let-7a* hsa-let-7a-1 9 19528081
hsa-let-7a* hsa-let-7a-3 22 19528081
hsa-let-7b hsa-let-7b 22 19528081
hsa-let-7b hsa-let-7b 22 19528081
hsa-let-7b* hsa-let-7b 22 19528081
hsa-let-7b* hsa-let-7b 22 19528081
hsa-let-7c hsa-let-7c 21 19528081
hsa-let-7c hsa-let-7c 21 19528081
hsa-let-7c* hsa-let-7c 21 19528081
hsa-let-7c* hsa-let-7c 21 19528081
hsa-let-7d hsa-let-7d 9 19528081
hsa-let-7d hsa-let-7d 9 19528081
hsa-let-7d* hsa-let-7d 9 19528081
hsa-let-7d* hsa-let-7d 9 19528081
hsa-let-7e hsa-let-7e 19 19528081
hsa-let-7e hsa-let-7e 19 19528081
hsa-let-7e* hsa-let-7e 19 19528081
hsa-let-7e* hsa-let-7e 19 19528081
hsa-let-7f hsa-let-7f-1 9 19528081
hsa-let-7f hsa-let-7f-2 X 19528081
hsa-let-7f hsa-let-7f-1 9 19528081
hsa-let-7f hsa-let-7f-2 X 19528081
hsa-let-7f-1* hsa-let-7f-1 9 19528081
hsa-let-7f-1* hsa-let-7f-1 9 19528081
hsa-let-7f-2* hsa-let-7f-2 X 19528081
hsa-let-7f-2* hsa-let-7f-2 X 19528081
hsa-let-7g hsa-let-7g 3 19528081
hsa-let-7g hsa-let-7g 3 19528081
hsa-let-7g* hsa-let-7g 3 19528081
hsa-let-7g* hsa-let-7g 3 19528081
hsa-let-7i hsa-let-7i 12 19528081
hsa-let-7i hsa-let-7i 12 19528081
hsa-let-7i* hsa-let-7i 12 19528081
hsa-let-7i* hsa-let-7i 12 19528081
hsa-miR-17 hsa-mir-17 13 19706389
hsa-miR-17 hsa-mir-17 13 16940181
hsa-miR-17 hsa-mir-17 13 19706389
hsa-miR-17 hsa-mir-17 13 16940181
hsa-miR-17* hsa-mir-17 13 19706389
hsa-miR-17* hsa-mir-17 13 16940181
hsa-miR-17* hsa-mir-17 13 19706389
hsa-miR-17* hsa-mir-17 13 16940181
hsa-miR-18a hsa-mir-18a 13 19706389
hsa-miR-18a hsa-mir-18a 13 19706389
hsa-miR-18a* hsa-mir-18a 13 19706389
hsa-miR-18a* hsa-mir-18a 13 19706389
hsa-miR-19b hsa-mir-19b-1 13 19706389
hsa-miR-19b hsa-mir-19b-2 X 19706389
hsa-miR-19b hsa-mir-19b-1 13 19706389
hsa-miR-19b hsa-mir-19b-2 X 19706389
hsa-miR-20b hsa-mir-20b X 19706389
hsa-miR-20b hsa-mir-20b X 19706389
hsa-miR-20b* hsa-mir-20b X 19706389
hsa-miR-20b* hsa-mir-20b X 19706389
hsa-miR-21 hsa-mir-21 17 19528081
hsa-miR-21 hsa-mir-21 17 19528081
hsa-miR-21* hsa-mir-21 17 19528081
hsa-miR-21* hsa-mir-21 17 19528081
hsa-miR-29b hsa-mir-29b-1 7 19706389
hsa-miR-29b hsa-mir-29b-2 1 19706389
hsa-miR-29b hsa-mir-29b-1 7 19706389
hsa-miR-29b hsa-mir-29b-2 1 19706389
hsa-miR-92a hsa-mir-92a-1 13 19706389
hsa-miR-92a hsa-mir-92a-2 X 19706389
hsa-miR-92a hsa-mir-92a-1 13 19706389
hsa-miR-92a hsa-mir-92a-2 X 19706389
hsa-miR-98 hsa-mir-98 X 19528081
hsa-miR-98 hsa-mir-98 X 19528081
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
493 mRNA repression TRUE miR-17-5p NCOA3 / AIB1 in vitro reporter gene assay (Luciferase) 16940181
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000124151 mesenchymal-epithelial transition (MET) n_a n_a "lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
16468 mRNA NCOA3 chr20 45564063 45719019 96 EST chr20 45718498 45719718Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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