AutismKB 2.0

Annotation Detail for NRIP1


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Basic Information Top
Gene Symbol:NRIP1 ( FLJ77253,RIP140 )
Gene Full Name: nuclear receptor interacting protein 1
Band: 21q11.2-q21.1
Quick LinksEntrez ID:8204; OMIM: 602490; Uniprot ID:NRIP1_HUMAN; ENSEMBL ID: ENSG00000180530; HGNC ID: 8001
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
25LXXLL motif 1.
104Phosphoserine (By similarity).
111N6-acetyllysine (By similarity).
137LXXLL motif 2.
158N6-acetyllysine (By similarity).
189LXXLL motif 3.
207Phosphothreonine (By similarity).
270LXXLL motif 4.
286N6-acetyllysine (By similarity).
310N6-acetyllysine (By similarity).
356Phosphoserine (By similarity).
378Phosphoserine (By similarity).
384LXXLL motif 5.
446N6-acetyllysine.
446CTBP-binding; principal site.
481N6-acetyllysine (By similarity).
487Phosphoserine (By similarity).
504LXXLL motif 6.
518Phosphoserine (By similarity).
528N6-acetyllysine (By similarity).
542Phosphoserine (By similarity).
569CTBP-binding.
603CTBP-binding (Potential).
606N6-acetyllysine (By similarity).
671Phosphoserine (By similarity).
717LXXLL motif 7.
731Phosphothreonine.
823LXXLL motif 8.
931N6-acetyllysine (By similarity).
940LXXLL motif 9.
950CTBP-binding.
1001Phosphoserine (By similarity).
1074Ligand-dependent nuclear receptor binding
Location(AA) Modifications Resource
104Phosphoserine (By similarity).Swiss-Prot 53.0
111N6-acetyllysine (By similarity).Swiss-Prot 53.0
158N6-acetyllysine (By similarity).Swiss-Prot 53.0
207Phosphothreonine (By similarity).Swiss-Prot 53.0
286N6-acetyllysine (By similarity).Swiss-Prot 53.0
310N6-acetyllysine (By similarity).Swiss-Prot 53.0
356Phosphoserine (By similarity).Swiss-Prot 53.0
378Phosphoserine (By similarity).Swiss-Prot 53.0
446N6-acetyllysine.Swiss-Prot 53.0
481N6-acetyllysine (By similarity).Swiss-Prot 53.0
487Phosphoserine (By similarity).Swiss-Prot 53.0
518Phosphoserine (By similarity).Swiss-Prot 53.0
528N6-acetyllysine (By similarity).Swiss-Prot 53.0
542Phosphoserine (By similarity).Swiss-Prot 53.0
606N6-acetyllysine (By similarity).Swiss-Prot 53.0
671Phosphoserine (By similarity).Swiss-Prot 53.0
931N6-acetyllysine (By similarity).Swiss-Prot 53.0
1001Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
9Phosphoserine(CK1)HMM predict
52N-linkedHMM predict
99MethyllysineHMM predict
146Phosphothreonine(PKC)HMM predict
150Phosphoserine(ATM)HMM predict
156Phosphoserine(PKG)HMM predict
252Phosphoserine(IKK)HMM predict
252Phosphoserine(CAMK2)HMM predict
252Phosphoserine(CDC2)HMM predict
256Phosphoserine(CDK)HMM predict
256Phosphoserine(CDC2)HMM predict
256Phosphoserine(MAPK)HMM predict
256PhosphoserineHMM predict
256O-linkedHMM predict
260O-linkedHMM predict
264Phosphoserine(ATM)HMM predict
356Phosphoserine(CDC2)HMM predict
399Phosphoserine(CAMK2)HMM predict
408O-linkedHMM predict
417Phosphotyrosine(Jak)HMM predict
421N-linkedHMM predict
429Phosphoserine(ATM)HMM predict
429Phosphoserine(CK2)HMM predict
429Phosphoserine(IKK)HMM predict
436Phosphoserine(IKK)HMM predict
454Phosphoserine(CK2)HMM predict
462N-linkedHMM predict
490Phosphoserine(PKG)HMM predict
516N-linkedHMM predict
518Phosphoserine(CDK)HMM predict
518Phosphoserine(CDC2)HMM predict
542Phosphoserine(CDC2)HMM predict
546N-linkedHMM predict
549O-linkedHMM predict
549Phosphothreonine(CDK)HMM predict
552O-linkedHMM predict
553Phosphothreonine(CDK)HMM predict
559O-linkedHMM predict
564Phosphoserine(CDC2)HMM predict
567N-linkedHMM predict
582Phosphotyrosine(Jak)HMM predict
644Phosphoserine(CK1)HMM predict
644PhosphoserineHMM predict
671Phosphoserine(MAPK)HMM predict
676N-linkedHMM predict
679N-linkedHMM predict
689Phosphoserine(ATM)HMM predict
699Phosphoserine(ATM)HMM predict
731Phosphothreonine(CDK)HMM predict
731Phosphothreonine(MAPK)HMM predict
737Phosphoserine(CK2)HMM predict
807Phosphoserine(ATM)HMM predict
830Phosphotyrosine(Jak)HMM predict
883N-linkedHMM predict
917O-linkedHMM predict
919Phosphoserine(CK2)HMM predict
956Phosphoserine(PKB)HMM predict
956Phosphoserine(IKK)HMM predict
968N-linkedHMM predict
971N-linkedHMM predict
977Phosphoserine(CK1)HMM predict
997N-linkedHMM predict
1008Phosphothreonine(CDK)HMM predict
1011O-linkedHMM predict
1011Phosphoserine(CDC2)HMM predict
1011Phosphoserine(CDK)HMM predict
1027Phosphoserine(IKK)HMM predict
1054Phosphotyrosine(INSR)HMM predict
1054Phosphotyrosine(Syk)HMM predict
1080Phosphothreonine(PKC)HMM predict
1081Phosphoserine(CK1)HMM predict
1098Phosphoserine(CK1)HMM predict
1098Phosphoserine(IKK)HMM predict
1100Phosphoserine(ATM)HMM predict
1123Phosphoserine(CDK)HMM predict
1132N-linkedHMM predict
1138Phosphoserine(IKK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003489
  • Location:chr21 15255426-15262717
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog hESGSE18292 15281476 15282042 566 19042
TFAP2C MCF7GSE21234 15276558 15276904 346 14014
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FoxA1 MCF7MACSdata 15239476 15239668 192 15855
RARA MCF7GSE15244 15250135 15251725 1590 4497
Stat6 IL-4-hr4GSE17850 15251790 15252293 503 3385
TFAP2C MCF7GSE21234 15250067 15250732 665 5027
No data
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 19878981
hsa-let-7a hsa-let-7a-2 11 19878981
hsa-let-7a hsa-let-7a-3 22 19878981
hsa-let-7a* hsa-let-7a-1 9 19878981
hsa-let-7a* hsa-let-7a-3 22 19878981
hsa-let-7b hsa-let-7b 22 19878981
hsa-let-7b* hsa-let-7b 22 19878981
hsa-let-7c hsa-let-7c 21 19878981
hsa-let-7c* hsa-let-7c 21 19878981
hsa-let-7d hsa-let-7d 9 19878981
hsa-let-7d* hsa-let-7d 9 19878981
hsa-let-7e hsa-let-7e 19 19878981
hsa-let-7e* hsa-let-7e 19 19878981
hsa-let-7f hsa-let-7f-1 9 19878981
hsa-let-7f hsa-let-7f-2 X 19878981
hsa-let-7f-1* hsa-let-7f-1 9 19878981
hsa-let-7f-2* hsa-let-7f-2 X 19878981
hsa-let-7g hsa-let-7g 3 19878981
hsa-let-7g* hsa-let-7g 3 19878981
hsa-let-7i hsa-let-7i 12 19878981
hsa-let-7i* hsa-let-7i 12 19878981
hsa-miR-125b hsa-mir-125b-1 11 21375733
hsa-miR-125b hsa-mir-125b-2 21 21375733
hsa-miR-182 hsa-mir-182 7 21375733
hsa-miR-182* hsa-mir-182 7 21375733
hsa-miR-183 hsa-mir-183 7 21375733
hsa-miR-183* hsa-mir-183 7 21375733
hsa-miR-195 hsa-mir-195 17 21375733
hsa-miR-195* hsa-mir-195 17 21375733
hsa-miR-21 hsa-mir-21 17 21375733
hsa-miR-21* hsa-mir-21 17 21375733
hsa-miR-346 hsa-mir-346 10 19780716
hsa-miR-346 hsa-mir-346 10 19878981
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
16721 EST chr21 15255500 15258425 562 mRNA NRIP1 chr21 15255426 15262718Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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