AutismKB 2.0

Annotation Detail for TCF7L1


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Basic Information Top
Gene Symbol:TCF7L1 ( TCF-3,TCF3 )
Gene Full Name: transcription factor 7-like 1 (T-cell specific, HMG-box)
Band: 2p11.2
Quick LinksEntrez ID:83439; OMIM: 604652; Uniprot ID:TF7L1_HUMAN; ENSEMBL ID: ENSG00000152284; HGNC ID: 11640
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
427Nuclear localization signal (Potential).
Location(AA) Modifications Resource
Location(AA) Modification Resource
52Phosphoserine(CK2)HMM predict
52Phosphoserine(CK1)HMM predict
53Phosphoserine(ATM)HMM predict
53O-linkedHMM predict
55Phosphoserine(IKK)HMM predict
68Phosphoserine(PKG)HMM predict
75N-linkedHMM predict
80Phosphoserine(CK2)HMM predict
80Phosphoserine(CK1)HMM predict
82Phosphoserine(CK2)HMM predict
115MethyllysineHMM predict
141Phosphoserine(CDC2)HMM predict
167O-linkedHMM predict
167O-linkedHMM predict
169Phosphoserine(CDC2)HMM predict
169O-linkedHMM predict
171PhosphoserineHMM predict
192Phosphothreonine(MAPK)HMM predict
203O-linkedHMM predict
206Phosphoserine(ATM)HMM predict
209Phosphothreonine(CDK)HMM predict
228O-linkedHMM predict
237O-linkedHMM predict
237Phosphoserine(MAPK)HMM predict
237Phosphoserine(CDC2)HMM predict
303O-linkedHMM predict
323O-linkedHMM predict
325O-linkedHMM predict
325Phosphoserine(CDC2)HMM predict
332Phosphoserine(CDC2)HMM predict
335Phosphothreonine(PKC)HMM predict
407Phosphoserine(ATM)HMM predict
432Phosphoserine(IKK)HMM predict
432Phosphoserine(ATM)HMM predict
432Phosphoserine(CK1)HMM predict
436Phosphoserine(IKK)HMM predict
467Phosphoserine(IKK)HMM predict
467Phosphoserine(CDC2)HMM predict
470Phosphoserine(CK2)HMM predict
474Phosphoserine(IKK)HMM predict
478Phosphoserine(CDC2)HMM predict
481Phosphothreonine(MAPK)HMM predict
488Phosphoserine(MAPK)HMM predict
488O-linkedHMM predict
537Phosphoserine(ATM)HMM predict
558Phosphoserine(MAPK)HMM predict
561Phosphoserine(IKK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_031283
  • Location:chr2 85214244-85391014
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 85213549 85213701 152 620
CTCF CD4SISSRdata 85213549 85213701 152 620
Nanog ESGSE20650 85200421 85201072 651 13498
Nanog hESGSE18292 85200571 85200942 371 13488
Oct4 hESGSE21916 85200465 85201046 581 13489
hScc1 BcellGSE12603 85213499 85214785 1286 103
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 85394234 85394589 355 3397
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 85347041 85347364 323 0
CTCF CD4GSE12889 85366112 85366383 271 0
CTCF CD4SISSRdata 85347041 85347364 323 0
CTCF CD4SISSRdata 85366112 85366383 271 0
CTCF JurkatGSE12889 85366050 85366398 348 0
CTCF G2GSE9613 85214378 85215034 656 0
CTCF G2GSE9613 85242194 85242697 503 0
CTCF G2GSE9613 85244966 85245176 210 0
CTCF G2GSE9613 85246883 85247159 276 0
CTCF G2GSE9613 85254000 85254181 181 0
CTCF G2GSE9613 85261622 85261908 286 0
CTCF G2GSE9613 85266915 85267207 292 0
CTCF G2GSE9613 85270112 85270488 376 0
CTCF G2GSE9613 85275127 85275430 303 0
CTCF G2GSE9613 85324244 85324924 680 0
CTCF G2GSE9613 85336038 85337104 1066 0
CTCF G2GSE9613 85347020 85347199 179 0
CTCF G2GSE9613 85354352 85354710 358 0
CTCF G2GSE9613 85357440 85358038 598 0
CTCF G2GSE9613 85365890 85366498 608 0
CTCF G2GSE9613 85379318 85379834 516 0
CTCF G2GSE9613 85380949 85381375 426 0
CTCF G2GSE9613 85384883 85385211 328 0
CTCF G2GSE9613 85385791 85386020 229 0
ER MCF7GSE19013 85214230 85214873 643 0
ER MCF7GSE19013 85316732 85317187 455 0
FOXA1 MCF7GSE15244 85339606 85340947 1341 0
FoxA1 MCF7MACSdata 85339621 85340035 414 0
FoxA1 MCF7MACSdata 85340093 85340319 226 0
H3K27me3 colorectalcancer 85215760 85216640 880 0
H3ac HepG2E 85387746 85391353 3607 0
KLF4 hESGSE17917 85228007 85228172 165 0
Myc K562GSE19551 85347099 85347452 353 0
Myc K562GSE19551 85380968 85381236 268 0
Nanog hESGSE18292 85215625 85215908 283 0
Oct1 H2O2-HelaGSE14283 85367485 85367518 33 0
Oct1 H2O2-HelaGSE14283 85383274 85383308 34 0
Oct1 HelaGSE14283 85342818 85342848 30 0
Oct1 HelaGSE14283 85367486 85367518 32 0
Oct1 HelaGSE14283 85382720 85382769 49 0
Oct4 hESGSE21916 85214869 85216350 1481 0
P300 T0-glioblastomaGSE21026 85296006 85297204 1198 0
P300 T30-glioblastomaGSE21026 85295905 85297247 1342 0
P300 T30-glioblastomaGSE21026 85329264 85330030 766 0
P300 T30-glioblastomaGSE21026 85354990 85355592 602 0
RARA MCF7GSE15244 85339675 85340947 1272 0
Rb GrowingGSE19898 85355038 85355371 333 0
Rb GrowingGSE19898 85356696 85356899 203 0
Rb QuiescentGSE19898 85296121 85296237 116 0
TFAP2C MCF7GSE21234 85226123 85226652 529 0
TFAP2C MCF7GSE21234 85237983 85238350 367 0
TFAP2C MCF7GSE21234 85337711 85338586 875 0
TFAP2C MCF7GSE21234 85339623 85340334 711 0
TFAP2C MCF7GSE21234 85366076 85366537 461 0
USF1 HepG2E 85312111 85312710 599 0
USF1 HepG2E 85387599 85388254 655 0
USF1 HepG2E 85389313 85391353 2040 0
hScc1 BcellGSE12603 85365925 85366498 573 0
hScc1 BcellGSE12603 85379352 85379761 409 0
hScc1 BcellGSE12603 85386526 85386714 188 0
hScc1 CdLSGSE12603 85365925 85366498 573 0
hScc1 G2GSE9613 85365890 85366498 608 0
hScc1 G2GSE9613 85379149 85379797 648 0
hScc1 G2GSE9613 85380839 85381375 536 0
p130 QuiescentGSE19898 85296481 85296834 353 0
p130 QuiescentGSE19898 85366185 85366397 212 0
p130 QuiescentGSE19898 85379381 85379642 261 0
p130 SenescentGSE19898 85336731 85337148 417 0
p130 shRbSenescentGSE19898 85296209 85296523 314 0
p63 keratinocytesGSE17611 85318154 85319033 879 0
p63 keratinocytesGSE17611 85368861 85369694 833 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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