AutismKB 2.0

Annotation Detail for TLN2


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Basic Information Top
Gene Symbol:TLN2 ( DKFZp451B1011,DKFZp686I0976,DKFZp686K0979,ILWEQ,KIAA0320 )
Gene Full Name: talin 2
Band: 15q22.2
Quick LinksEntrez ID:83660; OMIM: 607349; Uniprot ID:TLN2_HUMAN; ENSEMBL ID: ENSG00000171914; HGNC ID: 15447
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
28Phosphotyrosine (By similarity).
1543N6-acetyllysine.
1665Phosphotyrosine.
1843Phosphothreonine.
Location(AA) Modifications Resource
1843Phosphothreonine.Swiss-Prot 53.0
1843PhosphothreoninePhospho.ELM 6.0
Location(AA) Modification Resource
72SulfotyrosineHMM predict
129SulfotyrosineHMM predict
169Phosphothreonine(CK2)HMM predict
190N-linkedHMM predict
227N-linkedHMM predict
368Phosphoserine(IKK)HMM predict
376Phosphotyrosine(EGFR)HMM predict
376Phosphotyrosine(INSR)HMM predict
380Phosphotyrosine(Syk)HMM predict
428Phosphoserine(ATM)HMM predict
428Phosphoserine(CDK)HMM predict
428Phosphoserine(CDC2)HMM predict
440N-linkedHMM predict
461Phosphoserine(IKK)HMM predict
517Phosphoserine(CK1)HMM predict
559O-linkedHMM predict
562N-linkedHMM predict
573SulfotyrosineHMM predict
573Phosphotyrosine(Syk)HMM predict
585O-linkedHMM predict
586N-linkedHMM predict
607Phosphoserine(CK2)HMM predict
639O-linkedHMM predict
661N-linkedHMM predict
717Phosphoserine(ATM)HMM predict
727O-linkedHMM predict
732Phosphoserine(CDC2)HMM predict
762Phosphothreonine(CK2)HMM predict
775Phosphoserine(IKK)HMM predict
934O-linkedHMM predict
1040Phosphoserine(ATM)HMM predict
1197Phosphoserine(IKK)HMM predict
1242Phosphoserine(CK1)HMM predict
1296Phosphothreonine(CK2)HMM predict
1413Phosphoserine(ATM)HMM predict
1456Phosphoserine(ATM)HMM predict
1456Phosphoserine(IKK)HMM predict
1489O-linkedHMM predict
1489Phosphoserine(CDC2)HMM predict
1491Phosphoserine(IKK)HMM predict
1491Phosphoserine(ATM)HMM predict
1536N-linkedHMM predict
1540N-linkedHMM predict
1553Phosphoserine(CK2)HMM predict
1573N-linkedHMM predict
1585Phosphoserine(IKK)HMM predict
1595Phosphoserine(IKK)HMM predict
1595Phosphoserine(ATM)HMM predict
1734Phosphothreonine(PKA)HMM predict
1837Phosphoserine(CK1)HMM predict
1857Phosphothreonine(PKC)HMM predict
1894SulfotyrosineHMM predict
1946Phosphotyrosine(Jak)HMM predict
1959Phosphothreonine(PKC)HMM predict
2041Phosphothreonine(MAPK)HMM predict
2041Phosphothreonine(CDK)HMM predict
2125N-linkedHMM predict
2144Phosphothreonine(PKA)HMM predict
2172PhosphoserineHMM predict
2172Phosphoserine(CDC2)HMM predict
2172Phosphoserine(ATM)HMM predict
2172Phosphoserine(CK2)HMM predict
2172Phosphoserine(IKK)HMM predict
2358O-linkedHMM predict
2413N-linkedHMM predict
2525IsoleucineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015059
  • Location:chr15 60726801-60920732
  • strand:+
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 60929603 60930847 1244 9493
CTCF CD4GSE12889 60927236 60927481 245 6626
CTCF CD4SISSRdata 60927236 60927481 245 6626
CTCF G2GSE9613 60926962 60927342 380 6420
ER Breast-CancerGSE22609 60924444 60925204 760 4092
ER MCF7GSE19013 60924564 60925370 806 4235
P300 T30-glioblastomaGSE21026 60929378 60930739 1361 9326
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 60821948 60822188 240 0
CTCF CD4SISSRdata 60821948 60822188 240 0
CTCF G2GSE9613 60777218 60777471 253 0
CTCF G2GSE9613 60821840 60822418 578 0
CTCF G2GSE9613 60861306 60861812 506 0
CTCF G2GSE9613 60876617 60877206 589 0
ER E2-MCF7GSE14664 60764600 60764635 35 0
ER Fulvestrant-MCF7GSE14664 60764595 60764636 41 0
ER MCF7GSE19013 60859195 60859695 500 0
ER MCF7GSE19013 60911366 60913034 1668 0
ER MCF7GSE10800 60911556 60912542 986 0
FoxA1 MCF7MACSdata 60911514 60911895 381 0
Myc K562GSE19551 60727010 60727234 224 0
Nanog hESGSE18292 60855239 60855622 383 0
Oct1 H2O2-HelaGSE14283 60820282 60820321 39 0
Oct1 H2O2-HelaGSE14283 60826287 60826315 28 0
Oct1 HelaGSE14283 60756779 60756808 29 0
Oct1 HelaGSE14283 60764593 60764635 42 0
Oct1 HelaGSE14283 60812025 60812097 72 0
Oct1 HelaGSE14283 60820281 60820360 79 0
Oct1 HelaGSE14283 60846332 60846362 30 0
P300 T30-glioblastomaGSE21026 60726707 60727599 892 0
P300 T30-glioblastomaGSE21026 60837523 60838502 979 0
P300 T30-glioblastomaGSE21026 60849978 60850852 874 0
Rb QuiescentGSE19898 60868469 60868706 237 0
STAT1 HeLaGSE12782 60914110 60915319 1209 0
STAT1 HeLaGSE12783 60914110 60915319 1209 0
STAT1 IFNSISSRdata 60914287 60915144 857 0
TFAP2C MCF7GSE21234 60911445 60912035 590 0
hScc1 BcellGSE12603 60821952 60822313 361 0
hScc1 BcellGSE12603 60861488 60861812 324 0
hScc1 BcellGSE12603 60875285 60875600 315 0
hScc1 BcellGSE12603 60919545 60919900 355 0
hScc1 CdLSGSE12603 60821770 60822350 580 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
8915 mRNA TLN2 chr15 60726801 60920733 126 mRNA chr15 60911375 60914649Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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