AutismKB 2.0

Annotation Detail for SESN2


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Basic Information Top
Gene Symbol:SESN2 ( DKFZp761M0212,DKFZp761M02121,HI95,SES2,SEST2 )
Gene Full Name: sestrin 2
Band: 1p35.3
Quick LinksEntrez ID:83667; OMIM: 607767; Uniprot ID:SESN2_HUMAN; ENSEMBL ID: ENSG00000130766; HGNC ID: 20746
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
No data
Location(AA) Modification Resource
60Phosphoserine(CK1)HMM predict
160Phosphoserine(PKG)HMM predict
160Phosphoserine(CAMK2)HMM predict
204S-palmitoylHMM predict
225O-linkedHMM predict
225PhosphoserineHMM predict
232Phosphothreonine(MAPK)HMM predict
232Phosphothreonine(CDK)HMM predict
232Phosphothreonine(CDC2)HMM predict
232O-linkedHMM predict
235Phosphoserine(CK2)HMM predict
235O-linkedHMM predict
279Phosphoserine(ATM)HMM predict
307Phosphoserine(ATM)HMM predict
323Phosphotyrosine(Syk)HMM predict
342SulfotyrosineHMM predict
349Phosphotyrosine(INSR)HMM predict
410SulfotyrosineHMM predict
427Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_031459
  • Location:chr1 28458592-28481587
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 28458006 28458981 975 99
H3ac HepG2E 28457585 28458471 886 565
Rb shRbSenescenceGSE19898 28455365 28455567 202 3127
TAF k562GSE8489 28448420 28449151 731 9807
TAF k562GSE8489 28457438 28458440 1002 654
p130 shRbQuiescentGSE19898 28457852 28458444 592 445
p130 shRbSenescentGSE19898 28458130 28458402 272 327
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
HIF1 HypoHepG2 28495664 28496133 469 14311
Nanog hESGSE18292 28489908 28490206 298 8470
Nanog hESGSE18292 28496001 28496278 277 14552
RARA MCF7GSE15244 28495664 28496240 576 14365
STAT1 HeLaGSE12783 28500250 28501822 1572 19449
TFAP2C MCF7GSE21234 28486502 28486952 450 5140
USF1 HepG2E 28495664 28496534 870 14512
USF2 HepG2E 28495664 28496240 576 14365
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF JurkatGSE12889 28473924 28474133 209 0
CTCF G2GSE9613 28471664 28471805 141 0
H3K4me3 colorectalcancer 28459518 28460343 825 0
H3ac HepG2E 28459815 28460682 867 0
H3ac HepG2E 28462060 28462746 686 0
Myc K562GSE19551 28477818 28478350 532 0
Oct1 H2O2-HelaGSE14283 28461917 28461947 30 0
P300 T30-glioblastomaGSE21026 28457908 28459478 1570 0
PHF8 HeLaGSE20725 28458199 28459981 1782 0
TAF k562GSE8489 28459780 28460411 631 0
hScc1 BcellGSE12603 28471529 28471897 368 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018