AutismKB 2.0

Annotation Detail for PPP1R1B


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Basic Information Top
Gene Symbol:PPP1R1B ( DARPP-32,DARPP32,FLJ20940 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 1B
Band: 17q12
Quick LinksEntrez ID:84152; OMIM: 604399; Uniprot ID:PPR1B_HUMAN; ENSEMBL ID: ENSG00000131771; HGNC ID: 9287
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1N-acetylmethionine (By similarity).
34Phosphothreonine; by PKA (By similarity).
75Phosphothreonine; by CDK5.
102Phosphoserine (By similarity).
198Phosphoserine (By similarity).
Location(AA) Modifications Resource
1N-acetylmethionine (By similarity).Swiss-Prot 53.0
34Phosphothreonine (by PKA) (Bysimilarity).Swiss-Prot 53.0
75Phosphothreonine (by CDK5).Swiss-Prot 53.0
75Phosphothreonine (CDK
198Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
18Phosphoserine(IKK)HMM predict
34Phosphothreonine(PKA)HMM predict
42Phosphoserine(CK2)HMM predict
45Phosphoserine(CK1)HMM predict
45Phosphoserine(CK2)HMM predict
46Phosphoserine(CK2)HMM predict
46Phosphoserine(ATM)HMM predict
75Phosphothreonine(CDK)HMM predict
102Phosphoserine(CK2)HMM predict
102Phosphoserine(CK2)HMM predict
137Phosphoserine(ATM)HMM predict
137Phosphoserine(IKK)HMM predict
137Phosphoserine(CK1)HMM predict
188Phosphoserine(CK1)HMM predict
198Phosphoserine(CDC2)HMM predict
198Phosphoserine(IKK)HMM predict
198O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_032192
  • Location:chr17 35036704-35046400
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 35031749 35032297 548 4682
CTCF CD4SISSRdata 35031749 35032297 548 4682
CTCF G2GSE9613 35031308 35032295 987 4903
CTCF G2GSE9613 35033111 35033444 333 3427
CTCF G2GSE9613 35035768 35036227 459 707
Nanog hESGSE18292 35027999 35028370 371 8520
STAT1 IFNSISSRdata 35031550 35032408 858 4726
hScc1 BcellGSE12603 35027489 35028163 674 8879
hScc1 BcellGSE12603 35031739 35032295 556 4688
hScc1 BcellGSE12603 35033025 35033444 419 3470
hScc1 CdLSGSE12603 35031617 35032295 678 4749
hScc1 CdLSGSE12603 35033025 35033705 680 3340
hScc1 G2GSE9613 35031551 35032295 744 4782
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 35036597 35037305 708 0
hScc1 BcellGSE12603 35036700 35037305 605 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018