AutismKB 2.0

Annotation Detail for CUL3


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Basic Information Top
Gene Symbol:CUL3 ( - )
Gene Full Name: cullin 3
Band: 2q36.2
Quick LinksEntrez ID:8452; OMIM: 603136; Uniprot ID:CUL3_HUMAN; ENSEMBL ID: ENSG00000036257; HGNC ID: 2553
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
58Phosphotyrosine.
450Phosphoserine (By similarity).
737Phosphoserine.
Location(AA) Modifications Resource
58Phosphotyrosine.Swiss-Prot 53.0
58PhosphotyrosinePhospho.ELM 6.0
712Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in NEDD8) (Bysimilarity).Swiss-Prot 53.0
737Phosphoserine.Swiss-Prot 53.0
737PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
14Phosphothreonine(PKC)HMM predict
48N-linkedHMM predict
49N-linkedHMM predict
201Phosphotyrosine(Syk)HMM predict
432Phosphotyrosine(EGFR)HMM predict
442Phosphothreonine(PKC)HMM predict
443N-linkedHMM predict
447Phosphoserine(CK2)HMM predict
460PhosphothreonineHMM predict
478Phosphoserine(IKK)HMM predict
481N-linkedHMM predict
515O-linkedHMM predict
515O-linkedHMM predict
519O-linkedHMM predict
549Phosphothreonine(PKC)HMM predict
560N-linkedHMM predict
587Phosphothreonine(PKC)HMM predict
611Phosphotyrosine(Jak)HMM predict
645Phosphothreonine(PKC)HMM predict
676Phosphothreonine(PKC)HMM predict
691Phosphothreonine(PKC)HMM predict
737Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003590
  • Location:chr2 225043112-225158357
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K4me3 colorectalcancer 225158855 225159265 410 703
LIN9 G0GSE7516 225157972 225159114 1142 186
Oct4 hESGSE17917 225158302 225158587 285 87
TAF k562GSE8489 225158773 225159620 847 839
TFAP2C MCF7GSE21234 225158275 225158713 438 137
USF1 HepG2E 225158473 225159620 1147 689
USF2 HepG2E 225158531 225159480 949 648
p130 QuiescentGSE19898 225158497 225158992 495 387
p130 SenescentGSE19898 225158391 225159175 784 426
p130 shRbQuiescentGSE19898 225158226 225159034 808 273
p130 shRbSenescentGSE19898 225158229 225159109 880 312
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
hScc1 G2GSE9613 225030245 225030373 128 12804
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 225057959 225058894 935 0
CTCF G2GSE9613 225157398 225158277 879 0
FoxA1 MCF7MACSdata 225058386 225058607 221 0
H3K4me3 colorectalcancer 225156340 225157508 1168 0
H3ac HepG2E 225155410 225156016 606 0
H3ac HepG2E 225156340 225157398 1058 0
P300 T30-glioblastomaGSE21026 225057877 225058918 1041 0
PHF8 HeLaGSE20725 225157332 225158498 1166 0
PHF8 Hs68minusFBSGSE20725 225157264 225159209 1945 0
PHF8 Hs68plusFBSGSE20725 225157064 225159079 2015 0
VDR GM10861-stimGSE22484 225156711 225159776 3065 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018