AutismKB 2.0

Annotation Detail for CUL2


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Basic Information Top
Gene Symbol:CUL2 ( MGC131970 )
Gene Full Name: cullin 2
Band: 10p11.21
Quick LinksEntrez ID:8453; OMIM: 603135; Uniprot ID:CUL2_HUMAN; ENSEMBL ID: ENSG00000108094; HGNC ID: 2552
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
393N6-acetyllysine.
394Phosphotyrosine (By similarity).
661Phosphothreonine.
Location(AA) Modifications Resource
689Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in NEDD8).Swiss-Prot 53.0
Location(AA) Modification Resource
219SulfotyrosineHMM predict
230Phosphoserine(IKK)HMM predict
233Phosphoserine(ATM)HMM predict
329N-linkedHMM predict
334N-linkedHMM predict
477Phosphotyrosine(Jak)HMM predict
526O-linkedHMM predict
573Phosphotyrosine(Jak)HMM predict
589N-linkedHMM predict
590N-linkedHMM predict
627Phosphoserine(CK2)HMM predict
643N-linkedHMM predict
705Phosphoserine(CK1)HMM predict
737Phosphoserine(CK2)HMM predict
741Phosphotyrosine(SRC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003591
  • Location:chr10 35338813-35419299
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 35419004 35419995 991 200
H3ac HepG2E 35419530 35420409 879 670
Oct4 hESGSE17917 35419282 35419780 498 232
P300 T30-glioblastomaGSE21026 35419129 35420129 1000 330
USF2 HepG2E 35419446 35420379 933 613
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 35323667 35323918 251 15021
CTCF CD4SISSRdata 35323667 35323918 251 15021
Fos K562GSE19551 35323450 35323998 548 15090
Nanog hESGSE18292 35332870 35333237 367 5760
P300 T30-glioblastomaGSE21026 35323377 35324213 836 15019
P300 T30-glioblastomaGSE21026 35334674 35335587 913 3683
Sox2 hESGSE18292 35332789 35333220 431 5809
hScc1 BcellGSE12603 35323539 35324114 575 14987
hScc1 CdLSGSE12603 35323473 35324150 677 15002
hScc1 G2GSE9613 35323507 35324008 501 15056
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 35356684 35356799 115 0
CTCF CD4SISSRdata 35356684 35356799 115 0
FoxA1 MCF7MACSdata 35371857 35372038 181 0
GABP HelaGSE8489 35385058 35385239 181 0
H3K4me2 HCT116GSE10453 35418138 35418454 316 0
H3K4me3 colorectalcancer 35418138 35418859 721 0
H3ac HepG2E 35416425 35417096 671 0
H3ac HepG2E 35418138 35419096 958 0
Myc K562GSE19551 35350548 35350863 315 0
Nanog ESGSE20650 35341608 35342059 451 0
Nanog ESGSE20650 35350505 35350780 275 0
Oct1 H2O2-HelaGSE14283 35352312 35352350 38 0
Oct1 H2O2-HelaGSE14283 35390974 35391021 47 0
Oct1 H2O2-HelaGSE14283 35398066 35398108 42 0
Oct1 H2O2-HelaGSE14283 35404683 35404710 27 0
Oct1 HelaGSE14283 35347013 35347041 28 0
Oct1 HelaGSE14283 35377645 35377681 36 0
Oct1 HelaGSE14283 35390976 35391020 44 0
Oct1 HelaGSE14283 35398066 35398108 42 0
Oct4 ESGSE20650 35341698 35342051 353 0
Oct4 ESGSE20650 35350589 35350790 201 0
Oct4 hESGSE17917 35341780 35342031 251 0
Oct4 hESGSE21916 35341727 35342082 355 0
P300 T30-glioblastomaGSE21026 35386866 35387584 718 0
RING1B hESGSE13084 35350180 35350688 508 0
Sox2 hESGSE18292 35341682 35342054 372 0
TAF k562GSE8489 35416218 35417132 914 0
TAF k562GSE8489 35418138 35418791 653 0
TAFII hESGSE17917 35350354 35350544 190 0
hScc1 CdLSGSE12603 35418891 35419474 583 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-424 hsa-mir-424 X 20972335
hsa-miR-424* hsa-mir-424 X 20972335
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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