Annotation Detail for TUBB6

View Evidences	View Variants	View Annotations

Basic Information Top

Gene Symbol:	TUBB6 ( HsT1601,MGC132410,MGC4083,TUBB-5 )
Gene Full Name:	tubulin, beta 6
Band:	18p11.21
Quick Links	Entrez ID:84617; OMIM: NA; Uniprot ID:TBB6_HUMAN; ENSEMBL ID: ENSG00000176014; HGNC ID: 20776
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:2 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:18 results

Location(AA)	Modification
56	Phosphoserine.
106	Phosphotyrosine (By similarity).

Location(AA)	Modification	Resource
52	N-linked	HMM predict
59	Phosphotyrosine(Jak)	HMM predict
172	Phosphoserine(CDK)	HMM predict
172	Phosphoserine(CDC2)	HMM predict
172	Phosphoserine(ATM)	HMM predict
176	O-linked	HMM predict
184	N-linked	HMM predict
222	Phosphotyrosine(SRC)	HMM predict
234	Phosphoserine(IKK)	HMM predict
275	O-linked	HMM predict
281	Phosphotyrosine(EGFR)	HMM predict
285	Phosphothreonine(PKC)	HMM predict
312	Phosphothreonine(PKC)	HMM predict
337	N-linked	HMM predict
370	N-linked	HMM predict
409	Phosphothreonine(CK2)	HMM predict
425	Phosphotyrosine(SRC)	HMM predict
425	Phosphotyrosine(Syk)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_032525
Location:chr18 12298256-12316566
strand:+

Upstream the gene:12 results
Downstream the gene:0 results
Inside the gene:18 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Gata2	K562	GSE18868	12292300	12293027	727	5593
Oct1	H2O2-Hela	GSE14283	12294602	12294640	38	3636
Oct1	Hela	GSE14283	12283591	12283625	34	14649
Oct1	Hela	GSE14283	12292096	12292126	30	6146
Oct1	Hela	GSE14283	12294602	12294640	38	3636
PHF8	Hs68plusFBS	GSE20725	12296957	12299192	2235	182
Pol2	GM12878	GSE19551	12297943	12298505	562	33
Rb	Growing	GSE19898	12297470	12297747	277	648
Rb	Senescent	GSE19898	12297463	12297751	288	650
hScc1	Bcell	GSE12603	12295035	12295398	363	3040
p130	Senescent	GSE19898	12297877	12298123	246	257
p130	shRbSenescent	GSE19898	12297373	12297769	396	686

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	12297974	12298980	1006	0
H3K27me3	colorectal	cancer	12299357	12300107	750	0
Oct1	Hela	GSE14283	12313797	12313824	27	0
PHF8	HeLa	GSE20725	12297457	12299456	1999	0
Rb	Growing	GSE19898	12298582	12298833	251	0
Rb	Growing	GSE19898	12298909	12299051	142	0
Rb	Quiescent	GSE19898	12298687	12299004	317	0
Rb	Senescent	GSE19898	12298590	12299082	492	0
Rb	shRbQuiescent	GSE19898	12298761	12299019	258	0
Rb	shRbSenescence	GSE19898	12298872	12299059	187	0
TFAP2C	MCF7	GSE21234	12311347	12311707	360	0
hScc1	Bcell	GSE12603	12297873	12299042	1169	0
hScc1	Bcell	GSE12603	12311410	12311693	283	0
hScc1	Bcell	GSE12603	12315509	12315941	432	0
p130	Quiescent	GSE19898	12298728	12299081	353	0
p130	Senescent	GSE19898	12298802	12299225	423	0
p130	shRbSenescent	GSE19898	12298657	12299132	475	0
p63	keratinocytes	GSE17611	12299514	12300549	1035	0

Validated miRNA targets

miR Walk:7 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-1	hsa-mir-1-2	18	15685193
hsa-miR-1	hsa-mir-1-1	20	15685193
hsa-miR-124	hsa-mir-124-1	8	15685193
hsa-miR-124	hsa-mir-124-2	8	15685193
hsa-miR-124	hsa-mir-124-3	20	15685193
hsa-miR-373	hsa-mir-373	19	15685193
hsa-miR-373*	hsa-mir-373	19	15685193

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved