AutismKB 2.0

Annotation Detail for IRS4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:IRS4 ( IRS-4,PY160 )
Gene Full Name: insulin receptor substrate 4
Band: Xq22.3
Quick LinksEntrez ID:8471; OMIM: 603510; Uniprot ID:IRS4_HUMAN; ENSEMBL ID: ENSG00000133124; HGNC ID: 6128
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
490YXXM motif 1.
703YXXM motif 2.
720YXXM motif 3.
746YXXM motif 4.
782YXXM motif 5.
831YXXM motif 6.
856Phosphoserine.
859Phosphoserine.
865Phosphoserine.
872Phosphoserine.
874Phosphoserine.
877Phosphoserine.
921Phosphotyrosine.
924YXXM motif 7.
1038Phosphotyrosine.
1107Phosphoserine.
1231Phosphoserine.
1237Phosphothreonine.
Location(AA) Modifications Resource
No data
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003604
  • Location:chrX 107862369-107866294
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 107866998 107867258 260 834
H3K27me3 colorectalcancer 107867172 107868124 952 1354
hScc1 G2GSE9613 107867067 107867437 370 958
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 107862729 107862959 230 0
CTCF G2GSE9613 107864414 107865684 1270 0
CTCF G2GSE9613 107865926 107866355 429 0
hScc1 BcellGSE12603 107864502 107865650 1148 0
hScc1 G2GSE9613 107865225 107865505 280 0
hScc1 G2GSE9613 107865926 107866634 708 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018