AutismKB 2.0

Annotation Detail for KLHL22


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Basic Information Top
Gene Symbol:KLHL22 ( KELCHL )
Gene Full Name: kelch-like 22 (Drosophila)
Band: 22q11.21
Quick LinksEntrez ID:84861; OMIM: NA; Uniprot ID:KLH22_HUMAN; ENSEMBL ID: ENSG00000099910; HGNC ID: 25888
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine (By similarity).
Location(AA) Modifications Resource
Location(AA) Modification Resource
24N-linkedHMM predict
25N-linkedHMM predict
33Phosphoserine(IKK)HMM predict
116Phosphoserine(CK1)HMM predict
198Phosphoserine(CK1)HMM predict
214Phosphotyrosine(Syk)HMM predict
279N-linkedHMM predict
285Phosphoserine(CDK)HMM predict
562Phosphotyrosine(INSR)HMM predict
562Phosphotyrosine(Jak)HMM predict
605Phosphothreonine(CDC2)HMM predict
605Phosphothreonine(CDK)HMM predict
609Phosphoserine(ATM)HMM predict
621Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_032775
  • Location:chr22 19125805-19180121
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 19180775 19181098 323 815
CTCF CD4SISSRdata 19180775 19181098 323 815
CTCF HelaGSE12889 19180859 19181125 266 871
CTCF G2GSE9613 19180901 19181248 347 953
PHF8 HeLaGSE20725 19179221 19181067 1846 23
PolII HeLaGSE12783 19179055 19181426 2371 119
Rb SenescentGSE19898 19180081 19180362 281 100
Rb SenescentGSE19898 19180514 19181011 497 641
hScc1 BcellGSE12603 19180901 19181079 178 869
hScc1 CdLSGSE12603 19180901 19181248 347 953
p130 QuiescentGSE19898 19180228 19180443 215 214
p130 QuiescentGSE19898 19180647 19180903 256 654
p130 shRbSenescentGSE19898 19180147 19180649 502 277
p130 shRbSenescentGSE19898 19180706 19181059 353 761
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 19140449 19140935 486 0
CTCF CD4SISSRdata 19140449 19140935 486 0
CTCF JurkatGSE12889 19140652 19140827 175 0
CTCF G2GSE9613 19140368 19140964 596 0
CTCF G2GSE9613 19177191 19177341 150 0
CTCF G2GSE9613 19179648 19180305 657 0
Myc K562GSE19551 19140201 19141052 851 0
PHF8 293TGSE20725 19179161 19180923 1762 0
PHF8 Hs68plusFBSGSE20725 19178885 19180959 2074 0
RARA MCF7GSE15244 19167545 19168125 580 0
RARG MCF7GSE15244 19167688 19168160 472 0
hScc1 BcellGSE12603 19140368 19141163 795 0
hScc1 BcellGSE12603 19167046 19167370 324 0
hScc1 BcellGSE12603 19179305 19180429 1124 0
hScc1 CdLSGSE12603 19140368 19140928 560 0
hScc1 CdLSGSE12603 19178980 19179271 291 0
hScc1 CdLSGSE12603 19179612 19180429 817 0
hScc1 G2GSE9613 19140368 19140964 596 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018