AutismKB 2.0

Annotation Detail for PPM1D


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PPM1D ( PP2C-DELTA,WIP1 )
Gene Full Name: protein phosphatase, Mg2+/Mn2+ dependent, 1D
Band: 17q23.3
Quick LinksEntrez ID:8493; OMIM: 605100; Uniprot ID:PPM1D_HUMAN; ENSEMBL ID: ENSG00000170836; HGNC ID: 9277
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
40Phosphoserine.
85Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
40PhosphoserineHMM predict
40Phosphoserine(CDC2)HMM predict
44Phosphoserine(CK1)HMM predict
46O-linkedHMM predict
46Phosphoserine(ATM)HMM predict
46Phosphoserine(IKK)HMM predict
46PhosphoserineHMM predict
54Phosphoserine(CDC2)HMM predict
54Phosphoserine(MAPK)HMM predict
54O-linkedHMM predict
85Phosphoserine(CDC2)HMM predict
85O-linkedHMM predict
96Phosphoserine(PKA)HMM predict
96Phosphoserine(PKG)HMM predict
97Phosphoserine(PKB)HMM predict
97Phosphoserine(CAMK2)HMM predict
97Phosphoserine(PKG)HMM predict
97Phosphoserine(PKA)HMM predict
97Phosphoserine(PKA)HMM predict
131Phosphothreonine(CK2)HMM predict
149S-palmitoylHMM predict
169O-linkedHMM predict
169O-linkedHMM predict
171O-linkedHMM predict
173O-linkedHMM predict
174O-linkedHMM predict
237N-linkedHMM predict
242N-linkedHMM predict
261Phosphothreonine(PKA)HMM predict
367N-linkedHMM predict
384N-linkedHMM predict
387N-linkedHMM predict
394N-linkedHMM predict
398Phosphoserine(CDC2)HMM predict
412O-linkedHMM predict
416O-linkedHMM predict
483Phosphothreonine(PKC)HMM predict
502N-linkedHMM predict
505N-linkedHMM predict
543Phosphoserine(IKK)HMM predict
559O-linkedHMM predict
565O-linkedHMM predict
565Phosphoserine(IKK)HMM predict
565O-linkedHMM predict
575Phosphoserine(PKA)HMM predict
579Phosphothreonine(PKC)HMM predict
605S-farnesylHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003620
  • Location:chr17 56032335-56096817
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K4me2 HCT116GSE10453 56031387 56032136 749 574
H3ac HepG2E 56030217 56032091 1874 1182
NRSF JurkatGSE13047 56018405 56019099 694 13584
NRSF mAbJurkat 56018089 56019065 976 13759
NRSF-mono JurkatQuESTdata 56018404 56019098 694 13585
NRSF-poly JurkatQuESTdata 56018492 56019092 600 13544
PHF8 HeLaGSE20725 56031499 56033086 1587 43
RARA MCF7GSE15244 56018457 56019065 608 13575
RARA MCF7GSE15244 56030217 56030892 675 1781
RARA MCF7GSE15244 56031341 56032173 832 579
RARG MCF7GSE15244 56030217 56030857 640 1799
RARG MCF7GSE15244 56031424 56032091 667 578
Rb QuiescentGSE19898 56031607 56032351 744 357
Rb SenescentGSE19898 56031390 56032729 1339 276
Rb shRbQuiescentGSE19898 56031636 56032369 733 333
Rb shRbSenescenceGSE19898 56031628 56032328 700 358
TAF HelaGSE8489 56030325 56031905 1580 1221
TAF k562GSE8489 56030217 56032058 1841 1198
p130 QuiescentGSE19898 56031531 56032432 901 354
p130 SenescentGSE19898 56031421 56032758 1337 246
p130 shRbSenescentGSE19898 56031552 56032718 1166 201
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 56070970 56071203 233 0
CTCF CD4SISSRdata 56070970 56071203 233 0
CTCF JurkatGSE12889 56070843 56071253 410 0
CTCF G2GSE9613 56033148 56033853 705 0
CTCF G2GSE9613 56070824 56071218 394 0
ER E2-MCF7GSE14664 56069005 56069038 33 0
ER E2-MCF7GSE14664 56079233 56079307 74 0
ER E2-MCF7GSE14664 56082398 56082430 32 0
ER Fulvestrant-MCF7GSE14664 56069004 56069039 35 0
FOXA1 MCF7GSE15244 56031530 56033621 2091 0
H3K4me3 colorectalcancer 56033065 56034320 1255 0
H3ac HepG2E 56033030 56035331 2301 0
Myc K562GSE19551 56070906 56071136 230 0
Nanog hESGSE18292 56070957 56071152 195 0
Oct1 H2O2-HelaGSE14283 56064011 56064057 46 0
Oct1 HelaGSE14283 56064011 56064057 46 0
Oct1 HelaGSE14283 56069004 56069033 29 0
Oct1 HelaGSE14283 56074398 56074433 35 0
RARA MCF7GSE15244 56033030 56035072 2042 0
RARA MCF7GSE15244 56071043 56071218 175 0
RARA MCF7GSE15244 56071889 56072141 252 0
RARA MCF7GSE15244 56073877 56074324 447 0
RARG MCF7GSE15244 56033030 56035072 2042 0
RARG MCF7GSE15244 56069565 56069934 369 0
RARG MCF7GSE15244 56073877 56074189 312 0
Rb GrowingGSE19898 56073881 56074116 235 0
hScc1 BcellGSE12603 56070824 56071218 394 0
hScc1 CdLSGSE12603 56070824 56071218 394 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-15a hsa-mir-15a 13 16204133
hsa-miR-15a* hsa-mir-15a 13 16204133
hsa-miR-16 hsa-mir-16-1 13 20668064
hsa-miR-16 hsa-mir-16-2 3 20668064
hsa-miR-16 hsa-mir-16-1 13 16204133
hsa-miR-16 hsa-mir-16-2 3 16204133
hsa-miR-210 hsa-mir-210 11 21175813
hsa-miR-24 hsa-mir-24-1 9 21175813
hsa-miR-24 hsa-mir-24-2 19 21175813
hsa-miR-29a hsa-mir-29a 7 21175813
hsa-miR-29a* hsa-mir-29a 7 21175813
hsa-miR-30a hsa-mir-30a 6 21175813
hsa-miR-30a* hsa-mir-30a 6 21175813
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved