AutismKB 2.0

Annotation Detail for DOCK7


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Basic Information Top
Gene Symbol:DOCK7 ( KIAA1771,ZIR2 )
Gene Full Name: dedicator of cytokinesis 7
Band: 1p31.3
Quick LinksEntrez ID:85440; OMIM: NA; Uniprot ID:DOCK7_HUMAN; ENSEMBL ID: ENSG00000116641; HGNC ID: 19190
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
28Phosphoserine.
30Phosphoserine.
180Phosphoserine.
182Phosphoserine.
439Phosphoserine (By similarity).
440Phosphoserine (By similarity).
882Phosphoserine.
888Phosphoserine.
894Phosphoserine.
896Phosphoserine.
898Phosphoserine.
900Phosphoserine.
905Phosphoserine.
907Phosphothreonine.
909Phosphothreonine.
910Phosphoserine.
929Phosphoserine.
964Phosphoserine (By similarity).
966Phosphothreonine (By similarity).
1383Phosphoserine.
1385Phosphothreonine.
1430Phosphoserine.
1432Phosphoserine.
1438Phosphoserine.
1962N6-acetyllysine.
Location(AA) Modifications Resource
321PhosphoserinePhospho.ELM 6.0
900Phosphoserine (By similarity).Swiss-Prot 53.0
964Phosphoserine (By similarity).Swiss-Prot 53.0
966Phosphothreonine (By similarity).Swiss-Prot 53.0
1432Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
27Phosphotyrosine(Jak)HMM predict
42N-linkedHMM predict
169Phosphotyrosine(Syk)HMM predict
169SulfotyrosineHMM predict
182Phosphoserine(IKK)HMM predict
182Phosphoserine(PKB)HMM predict
214Phosphothreonine(CDC2)HMM predict
241Phosphoserine(ATM)HMM predict
324Phosphothreonine(PKC)HMM predict
337Phosphoserine(ATM)HMM predict
382Phosphoserine(IKK)HMM predict
414Phosphoserine(CK1)HMM predict
432Phosphoserine(PKA)HMM predict
432Phosphoserine(PKG)HMM predict
432Phosphoserine(CAMK2)HMM predict
432Phosphoserine(IKK)HMM predict
438N-linkedHMM predict
439Phosphoserine(PKG)HMM predict
440Phosphoserine(PKG)HMM predict
452Phosphoserine(PKB)HMM predict
458N-linkedHMM predict
557N-linkedHMM predict
562N-linkedHMM predict
579PhosphoserineHMM predict
579Phosphoserine(PKA)HMM predict
623N-linkedHMM predict
661Phosphothreonine(MAPK)HMM predict
698Phosphotyrosine(SRC)HMM predict
699Phosphoserine(IKK)HMM predict
702Phosphoserine(CDC2)HMM predict
778N-linkedHMM predict
780Phosphoserine(ATM)HMM predict
861N-linkedHMM predict
863O-linkedHMM predict
864O-linkedHMM predict
864Phosphoserine(CDC2)HMM predict
864Phosphoserine(CDK)HMM predict
876Phosphotyrosine(INSR)HMM predict
892N-linkedHMM predict
896Phosphoserine(IKK)HMM predict
896Phosphoserine(PKA)HMM predict
896Phosphoserine(CK1)HMM predict
898Phosphoserine(IKK)HMM predict
905O-linkedHMM predict
905O-linkedHMM predict
929Phosphoserine(IKK)HMM predict
944N-linkedHMM predict
946PhosphoserineHMM predict
946Phosphoserine(CDC2)HMM predict
948O-linkedHMM predict
948O-linkedHMM predict
970Phosphoserine(IKK)HMM predict
1003Phosphoserine(PKG)HMM predict
1106Phosphotyrosine(INSR)HMM predict
1142Phosphothreonine(MAPK)HMM predict
1142PhosphothreonineHMM predict
1146Phosphoserine(ATM)HMM predict
1146PhosphoserineHMM predict
1146Phosphoserine(CDK)HMM predict
1146O-linkedHMM predict
1146Phosphoserine(CDC2)HMM predict
1148Phosphoserine(CDK)HMM predict
1148O-linkedHMM predict
1150Phosphoserine(CK1)HMM predict
1152O-linkedHMM predict
1153Phosphoserine(CK1)HMM predict
1156Phosphoserine(CK1)HMM predict
1156Phosphoserine(IKK)HMM predict
1156Phosphoserine(ATM)HMM predict
1221Phosphoserine(CK1)HMM predict
1229Phosphotyrosine(INSR)HMM predict
1229Phosphotyrosine(Abl)HMM predict
1229Phosphotyrosine(Jak)HMM predict
1230Phosphoserine(CK1)HMM predict
1277Phosphotyrosine(INSR)HMM predict
1277Phosphotyrosine(Syk)HMM predict
1279Phosphoserine(CK1)HMM predict
1279Phosphoserine(CK2)HMM predict
1286Phosphoserine(ATM)HMM predict
1306Phosphoserine(IKK)HMM predict
1425Phosphoserine(CDC2)HMM predict
1430Phosphoserine(CDC2)HMM predict
1432Phosphoserine(PKB)HMM predict
1432O-linkedHMM predict
1499Phosphoserine(CK1)HMM predict
1682Phosphothreonine(PKC)HMM predict
1730Phosphotyrosine(Syk)HMM predict
1757Phosphoserine(CK2)HMM predict
1757Phosphoserine(MAPK)HMM predict
1826Phosphoserine(CK1)HMM predict
1923Phosphotyrosine(Syk)HMM predict
1981N-linkedHMM predict
2079N-linkedHMM predict
2134Phosphoserine(PKC)HMM predict
2134Phosphoserine(PKA)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_033407
  • Location:chr1 62692986-62926556
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 62926202 62926942 740 16
H3ac HepG2E 62927009 62927755 746 826
H3ac HepG2E 62928168 62929652 1484 2354
Rb SenescentGSE19898 62926645 62926898 253 215
hScc1 BcellGSE12603 62926382 62927184 802 227
p130 QuiescentGSE19898 62928555 62928812 257 2127
p130 SenescentGSE19898 62927856 62928135 279 1439
p130 SenescentGSE19898 62928935 62929270 335 2546
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 62746425 62746738 313 0
CTCF CD4GSE12889 62768883 62769035 152 0
CTCF CD4SISSRdata 62746425 62746738 313 0
CTCF CD4SISSRdata 62768883 62769035 152 0
CTCF HelaGSE12889 62705193 62705393 200 0
CTCF G2GSE9613 62879447 62880012 565 0
ER E2-MCF7GSE14664 62729311 62729343 32 0
ER E2-MCF7GSE14664 62892036 62892078 42 0
ER Fulvestrant-MCF7GSE14664 62730019 62730061 42 0
H3ac HepG2E 62922747 62923117 370 0
H3ac HepG2E 62923598 62924180 582 0
H3ac HepG2E 62925355 62925821 466 0
Myc K562GSE19551 62860180 62860523 343 0
Nanog ESGSE20650 62715134 62715511 377 0
Nanog ESGSE20650 62726239 62726587 348 0
Nanog hESGSE18292 62714862 62715570 708 0
Nanog hESGSE18292 62726031 62726530 499 0
Oct1 H2O2-HelaGSE14283 62710150 62710184 34 0
Oct1 H2O2-HelaGSE14283 62727915 62727962 47 0
Oct1 HelaGSE14283 62710151 62710184 33 0
Oct1 HelaGSE14283 62727898 62727969 71 0
Oct1 HelaGSE14283 62782198 62782240 42 0
Oct1 HelaGSE14283 62892042 62892085 43 0
Oct1 HelaGSE14283 62919571 62919603 32 0
P300 T30-glioblastomaGSE21026 62860171 62860679 508 0
PHF8 293TGSE20725 62925399 62927350 1951 0
hScc1 CdLSGSE12603 62746254 62746833 579 0
hScc1 CdLSGSE12603 62926202 62926880 678 0
p130 QuiescentGSE19898 62925811 62925980 169 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1227 Unknown pSILAC miR-30 DOCK7 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000116641 n_a n_a n_a "epithelium, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
894 mRNA ANGPTL3 chr1 62775207 62783201 7994 mRNA DOCK7 chr1 62632417 62865990 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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