AutismKB 2.0

Annotation Detail for PIAS1


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Basic Information Top
Gene Symbol:PIAS1 ( DDXBP1,GBP,GU/RH-II,MGC141878,MGC141879,ZMIZ3 )
Gene Full Name: protein inhibitor of activated STAT, 1
Band: 15q23
Quick LinksEntrez ID:8554; OMIM: 603566; Uniprot ID:PIAS1_HUMAN; ENSEMBL ID: ENSG00000033800; HGNC ID: 2752
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
23LXXLL motif.
64Nuclear localization signal (Potential).
303Asymmetric dimethylarginine; by PRMT1.
380Nuclear localization signal (Potential).
466Phosphoserine.
467Phosphoserine.
468Phosphoserine.
483Phosphoserine (By similarity).
485Phosphoserine (By similarity).
487Phosphothreonine (By similarity).
503Phosphoserine.
510Phosphoserine.
522Phosphoserine.
Location(AA) Modifications Resource
466Phosphoserine.Swiss-Prot 53.0
466PhosphoserinePhospho.ELM 6.0
467Phosphoserine.Swiss-Prot 53.0
467PhosphoserinePhospho.ELM 6.0
468Phosphoserine.Swiss-Prot 53.0
468PhosphoserinePhospho.ELM 6.0
483PhosphoserinePhospho.ELM 6.0
483Phosphoserine (By similarity).Swiss-Prot 53.0
485Phosphoserine (By similarity).Swiss-Prot 53.0
487Phosphothreonine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
83O-linkedHMM predict
90O-linkedHMM predict
90Phosphoserine(CDC2)HMM predict
92O-linkedHMM predict
106Phosphoserine(CDK)HMM predict
225Phosphothreonine(PKC)HMM predict
233Phosphotyrosine(INSR)HMM predict
247Phosphoserine(PKA)HMM predict
251N-linkedHMM predict
259Phosphoserine(PKG)HMM predict
279Phosphoserine(PKA)HMM predict
322O-linkedHMM predict
362Phosphotyrosine(INSR)HMM predict
467Phosphoserine(CK2)HMM predict
468PhosphoserineHMM predict
468Phosphoserine(CK2)HMM predict
483O-linkedHMM predict
488Phosphoserine(CDC2)HMM predict
488Phosphoserine(IKK)HMM predict
506O-linkedHMM predict
508Phosphothreonine(CDK)HMM predict
510O-linkedHMM predict
510Phosphoserine(PKB)HMM predict
510Phosphoserine(IKK)HMM predict
510Phosphoserine(PKA)HMM predict
520N-linkedHMM predict
598O-linkedHMM predict
599O-linkedHMM predict
600O-linkedHMM predict
600Phosphoserine(IKK)HMM predict
600O-linkedHMM predict
605N-linkedHMM predict
609O-linkedHMM predict
611Phosphoserine(IKK)HMM predict
612N-linkedHMM predict
631N-linkedHMM predict
634O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_016166
  • Location:chr15 66133625-66267455
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
E2F4 G0GSE7516 66132951 66133539 588 381
LIN9 G0GSE7516 66132913 66133831 918 254
LIN9 SGSE7516 66132769 66133831 1062 326
TFAP2C MCF7GSE21234 66121850 66122458 608 11472
p130 QuiescentGSE19898 66133146 66133670 524 218
p130 SenescentGSE19898 66133073 66133823 750 178
p130 shRbQuiescentGSE19898 66132718 66133720 1002 407
p130 shRbSenescentGSE19898 66133005 66133810 805 218
p130 G0GSE7516 66132913 66133683 770 328
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 66234245 66234596 351 0
H3ac HepG2E 66133999 66135103 1104 0
Oct1 H2O2-HelaGSE14283 66208660 66208694 34 0
Oct1 HelaGSE14283 66208661 66208694 33 0
Oct1 HelaGSE14283 66246130 66246180 50 0
PHF8 293TGSE20725 66132966 66134327 1361 0
hScc1 BcellGSE12603 66133683 66134311 628 0
hScc1 BcellGSE12603 66234277 66234561 284 0
hScc1 CdLSGSE12603 66133480 66135286 1806 0
hScc1 CdLSGSE12603 66234206 66234770 564 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-205 hsa-mir-205 1 20065103
hsa-miR-224 hsa-mir-224 X 20065103
hsa-miR-335 hsa-mir-335 7 20065103
hsa-miR-335* hsa-mir-335 7 20065103
hsa-miR-424 hsa-mir-424 X 20065103
hsa-miR-424* hsa-mir-424 X 20065103
hsa-miR-451 hsa-mir-451 17 20065103
hsa-miR-491-3p hsa-mir-491 9 20065103
hsa-miR-491-5p hsa-mir-491 9 20065103
hsa-miR-93 hsa-mir-93 7 20065103
hsa-miR-93* hsa-mir-93 7 20065103
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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