AutismKB 2.0

Annotation Detail for RUNX1


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Basic Information Top
Gene Symbol:RUNX1 ( AML1,AML1-EVI-1,AMLCR1,CBFA2,EVI-1,PEBP2aB )
Gene Full Name: runt-related transcription factor 1
Band: 21q22.12
Quick LinksEntrez ID:861; OMIM: 151385; Uniprot ID:RUNX1_HUMAN; ENSEMBL ID: ENSG00000159216; HGNC ID: 10471
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
14Phosphothreonine.
21Phosphoserine.
24N6-acetyllysine.
43N6-acetyllysine.
249Phosphoserine.
266Phosphoserine.
268Phosphoserine.
276Phosphoserine.
Location(AA) Modifications Resource
14Phosphothreonine.Swiss-Prot 53.0
14PhosphothreoninePhospho.ELM 6.0
21Phosphoserine.Swiss-Prot 53.0
21PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
10O-linkedHMM predict
14Phosphothreonine(CDK)HMM predict
14Phosphothreonine(MAPK)HMM predict
14Phosphothreonine(PKA)HMM predict
17O-linkedHMM predict
21Phosphoserine(CDC2)HMM predict
82N-linkedHMM predict
145Phosphoserine(IKK)HMM predict
199Phosphoserine(CK2)HMM predict
199Phosphoserine(CK1)HMM predict
219Phosphothreonine(CDK)HMM predict
219Phosphothreonine(MAPK)HMM predict
219Phosphothreonine(CDC2)HMM predict
219O-linkedHMM predict
227N-linkedHMM predict
233N-linkedHMM predict
238Phosphoserine(IKK)HMM predict
249Phosphoserine(ATM)HMM predict
266Phosphoserine(MAPK)HMM predict
268O-linkedHMM predict
276Phosphoserine(CDC2)HMM predict
295Phosphoserine(PKG)HMM predict
329O-linkedHMM predict
331O-linkedHMM predict
353Phosphotyrosine(Syk)HMM predict
362O-linkedHMM predict
362O-linkedHMM predict
416N-linkedHMM predict
421N-linkedHMM predict
433Phosphoserine(IKK)HMM predict
433PhosphoserineHMM predict
435Phosphoserine(CDC2)HMM predict
435Phosphoserine(IKK)HMM predict
437O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001001890
  • Location:chr21 35081968-35182856
  • strand:-
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 35065702 35066197 495 16019
FoxA1 MCF7MACSdata 35069027 35069197 170 12857
P300 T30-glioblastomaGSE21026 35065574 35066435 861 15964
Rb QuiescentGSE19898 35079489 35079631 142 2409
TFAP2C MCF7GSE21234 35068816 35069242 426 12940
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 35175458 35176754 1296 0
FOXA1 MCF7GSE15244 35084908 35085349 441 0
FOXA1 MCF7GSE15244 35106493 35107219 726 0
FOXA1 MCF7GSE15244 35139633 35140334 701 0
FOXA1 MCF7GSE15244 35157986 35158569 583 0
FOXA1 MCF7GSE15244 35159067 35160237 1170 0
FOXA1 MCF7GSE15244 35170156 35170556 400 0
FOXA1 MCF7GSE15244 35171546 35172050 504 0
FOXA1 MCF7GSE15244 35172584 35173292 708 0
FoxA1 MCF7MACSdata 35139949 35140155 206 0
FoxA1 MCF7MACSdata 35172734 35173015 281 0
H3K4me3 colorectalcancer 35179578 35180422 844 0
H3K4me3 colorectalcancer 35181721 35182098 377 0
H3ac HepG2E 35089131 35089622 491 0
H3ac HepG2E 35111045 35111892 847 0
NFkBII GM12892GSE19485 35138331 35140586 2255 0
Nanog hESGSE18292 35129811 35129977 166 0
Nanog hESGSE18292 35160205 35160743 538 0
P300 T30-glioblastomaGSE21026 35101216 35103306 2090 0
P300 T30-glioblastomaGSE21026 35129398 35131629 2231 0
P300 T30-glioblastomaGSE21026 35139597 35141448 1851 0
P300 T30-glioblastomaGSE21026 35175155 35176812 1657 0
RARA MCF7GSE15244 35106604 35107219 615 0
RARA MCF7GSE15244 35140839 35141280 441 0
RARA MCF7GSE15244 35157692 35160589 2897 0
RARA MCF7GSE15244 35171340 35172239 899 0
RARG MCF7GSE15244 35140839 35141124 285 0
RARG MCF7GSE15244 35157660 35160370 2710 0
RARG MCF7GSE15244 35171340 35172161 821 0
STAT1 HeLaGSE12782 35178566 35184921 6355 0
Sox2 hESGSE18292 35160180 35160765 585 0
Stat6 IL-4-hr1GSE17850 35161700 35162527 827 0
TAF k562GSE8489 35181544 35182786 1242 0
TFAP2C MCF7GSE21234 35108591 35109057 466 0
TFAP2C MCF7GSE21234 35139795 35141177 1382 0
TFAP2C MCF7GSE21234 35158090 35158675 585 0
TFAP2C MCF7GSE21234 35160010 35160518 508 0
hScc1 BcellGSE12603 35095563 35095948 385 0
hScc1 BcellGSE12603 35137697 35138022 325 0
hScc1 BcellGSE12603 35159337 35159608 271 0
hScc1 BcellGSE12603 35180931 35181289 358 0
hScc1 CdLSGSE12603 35095599 35096272 673 0
p130 SenescentGSE19898 35181906 35182919 1013 0
p130 shRbQuiescentGSE19898 35101309 35101628 319 0
p130 shRbSenescentGSE19898 35129727 35130047 320 0
p63 keratinocytesGSE17611 35107245 35108118 873 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 21057539
hsa-let-7a hsa-let-7a-2 11 21057539
hsa-let-7a hsa-let-7a-3 22 21057539
hsa-let-7a* hsa-let-7a-1 9 21057539
hsa-let-7a* hsa-let-7a-3 22 21057539
hsa-let-7b hsa-let-7b 22 21057539
hsa-let-7b* hsa-let-7b 22 21057539
hsa-let-7c hsa-let-7c 21 21057539
hsa-let-7c* hsa-let-7c 21 21057539
hsa-let-7d hsa-let-7d 9 21057539
hsa-let-7d* hsa-let-7d 9 21057539
hsa-let-7e hsa-let-7e 19 21057539
hsa-let-7e* hsa-let-7e 19 21057539
hsa-let-7f hsa-let-7f-1 9 21057539
hsa-let-7f hsa-let-7f-2 X 21057539
hsa-let-7f-1* hsa-let-7f-1 9 21057539
hsa-let-7f-2* hsa-let-7f-2 X 21057539
hsa-let-7g hsa-let-7g 3 21057539
hsa-let-7g* hsa-let-7g 3 21057539
hsa-let-7i hsa-let-7i 12 21057539
hsa-let-7i* hsa-let-7i 12 21057539
hsa-miR-106a hsa-mir-106a X 17589498
hsa-miR-106a* hsa-mir-106a X 17589498
hsa-miR-10a hsa-mir-10a 17 18773208
hsa-miR-10a* hsa-mir-10a 17 18773208
hsa-miR-125b hsa-mir-125b-1 11 19890372
hsa-miR-125b hsa-mir-125b-2 21 19890372
hsa-miR-125b-2* hsa-mir-125b-2 21 19890372
hsa-miR-126 hsa-mir-126 9 18832181
hsa-miR-126 hsa-mir-126 9 18773208
hsa-miR-126* hsa-mir-126 9 18832181
hsa-miR-126* hsa-mir-126 9 18773208
hsa-miR-155 hsa-mir-155 21 20003307
hsa-miR-155* hsa-mir-155 21 20003307
hsa-miR-17 hsa-mir-17 13 20003307
hsa-miR-17 hsa-mir-17 13 18773208
hsa-miR-17 hsa-mir-17 13 17589498
hsa-miR-17* hsa-mir-17 13 20003307
hsa-miR-17* hsa-mir-17 13 18773208
hsa-miR-17* hsa-mir-17 13 17589498
hsa-miR-18a hsa-mir-18a 13 19114653
hsa-miR-18a* hsa-mir-18a 13 19114653
hsa-miR-20a hsa-mir-20a 13 18832181
hsa-miR-20a hsa-mir-20a 13 18773208
hsa-miR-20a hsa-mir-20a 13 17589498
hsa-miR-20a* hsa-mir-20a 13 18832181
hsa-miR-20a* hsa-mir-20a 13 18773208
hsa-miR-20a* hsa-mir-20a 13 17589498
hsa-miR-21 hsa-mir-21 17 20003307
hsa-miR-21* hsa-mir-21 17 20003307
hsa-miR-22 hsa-mir-22 17 21057539
hsa-miR-22* hsa-mir-22 17 21057539
hsa-miR-221 hsa-mir-221 X 21076613
hsa-miR-221* hsa-mir-221 X 21076613
hsa-miR-223 hsa-mir-223 X 18416028
hsa-miR-223 hsa-mir-223 X 17996649
hsa-miR-223* hsa-mir-223 X 18416028
hsa-miR-223* hsa-mir-223 X 17996649
hsa-miR-224 hsa-mir-224 X 18832181
hsa-miR-27a hsa-mir-27a 19 19114653
hsa-miR-27a hsa-mir-27a 19 19298589
hsa-miR-27a* hsa-mir-27a 19 19114653
hsa-miR-27a* hsa-mir-27a 19 19298589
hsa-miR-27b hsa-mir-27b 9 19298589
hsa-miR-27b* hsa-mir-27b 9 19298589
hsa-miR-30c hsa-mir-30c-2 6 19114653
hsa-miR-30c hsa-mir-30c-1 1 19114653
hsa-miR-320a hsa-mir-320a 8 20807887
hsa-miR-382 hsa-mir-382 14 18832181
hsa-miR-424 hsa-mir-424 X 20003307
hsa-miR-424* hsa-mir-424 X 20003307
hsa-miR-483-3p hsa-mir-483 11 19958507
hsa-miR-483-5p hsa-mir-483 11 19958507
hsa-miR-494 hsa-mir-494 14 20807887
hsa-miR-9 hsa-mir-9-1 1 19114653
hsa-miR-9 hsa-mir-9-2 5 19114653
hsa-miR-9 hsa-mir-9-3 15 19114653
hsa-miR-92a hsa-mir-92a-1 13 20003307
hsa-miR-92a hsa-mir-92a-2 X 20003307
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
16909 EST chr21 35181090 35181567 477 mRNA RUNX1 chr21 35081968 35182857Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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