AutismKB 2.0

Annotation Detail for AKR1C3


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Basic Information Top
Gene Symbol:AKR1C3 ( DD3,DDX,HA1753,HAKRB,HAKRe,HSD17B5,KIAA0119,PGFS,hluPGFS )
Gene Full Name: aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
Band: 10p15.1
Quick LinksEntrez ID:8644; OMIM: 603966; Uniprot ID:AK1C3_HUMAN; ENSEMBL ID: ENSG00000196139; HGNC ID: 386
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
Location(AA) Modification Resource
24Phosphotyrosine(INSR)HMM predict
55Phosphotyrosine(INSR)HMM predict
221Phosphoserine(ATM)HMM predict
232Phosphoserine(MAPK)HMM predict
251Phosphothreonine(PKA)HMM predict
317SulfotyrosineHMM predict
320SerineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003739
  • Location:chr10 5126567-5139875
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FoxA1 MCF7MACSdata 5112020 5112324 304 14396
Oct1 H2O2-HelaGSE14283 5113450 5113484 34 13101
Oct1 HelaGSE14283 5113449 5113512 63 13087
RARG MCF7GSE15244 5111231 5111462 231 15221
RARG MCF7GSE15244 5112140 5112492 352 14252
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
2747 mRNA AKR1C3 chr10 5126567 5139878 123 EST chr10 5021964 5134828Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018