Annotation Detail for SOCS1

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Basic Information Top

Gene Symbol:	SOCS1 ( CIS1,CISH1,JAB,SOCS-1,SSI-1,SSI1,TIP3 )
Gene Full Name:	suppressor of cytokine signaling 1
Band:	16p13.13
Quick Links	Entrez ID:8651; OMIM: 603597; Uniprot ID:SOCS1_HUMAN; ENSEMBL ID: ENSG00000185338; HGNC ID: 19383
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

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PTM Sites from Uniprot:0 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:8 results

No data

Location(AA)	Modification	Resource
27	O-linked	HMM predict
29	Phosphoserine(CK1)	HMM predict
31	Phosphoserine(CK1)	HMM predict
32	Phosphoserine(CDC2)	HMM predict
32	Phosphoserine(ATM)	HMM predict
32	Phosphoserine(IKK)	HMM predict
68	Phosphothreonine(PKA)	HMM predict
199	Valine	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_003745
Location:chr16 11255774-11257539
strand:-

Upstream the gene:15 results
Downstream the gene:7 results
Inside the gene:3 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	11257836	11259142	1306	950
CTCF	G2	GSE9613	11260139	11260585	446	2823
CTCF	G2	GSE9613	11262464	11262698	234	5042
ER	E2-MCF7	GSE14664	11261618	11261698	80	4119
ER	MCF7	GSE19013	11259932	11260748	816	2801
H3ac	HepG2	E	11258327	11258810	483	1029
H3ac	HepG2	E	11261062	11262698	1636	4341
NRSF	pAb	Jurkat	11257836	11258248	412	503
PHF8	Hs68minusFBS	GSE20725	11257486	11258200	714	304
Rb	Growing	GSE19898	11261857	11262006	149	4392
Rb	Senescent	GSE19898	11258736	11259220	484	1439
Stat6	IL-4-hr1	GSE17850	11257666	11258701	1035	644
hScc1	Bcell	GSE12603	11257318	11259142	1824	691
hScc1	CdLS	GSE12603	11256084	11259142	3058	74
p130	shRbQuiescent	GSE19898	11257707	11258136	429	382

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Fos	K562	GSE19551	11239690	11240429	739	15715
STAT1	HeLa	GSE12782	11241724	11242668	944	13579
STAT1	IFN	SISSRdata	11241927	11242513	586	13555
VDR	GM10855-Unstim	GSE22484	11251043	11258263	7220	1122
VDR	GM10855-stim	GSE22484	11251774	11259228	7454	274
VDR	GM10861-stim	GSE22484	11251065	11259393	8328	546
hScc1	Bcell	GSE12603	11251596	11252165	569	3894

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	11256656	11257395	739
Pol2	GM12878	GSE19551	11255794	11258257	2463
hScc1	Bcell	GSE12603	11256084	11256990	906

Validated miRNA targets

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miR Walk:99 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7a	hsa-let-7a-1	9	21352471
hsa-let-7a	hsa-let-7a-2	11	21352471
hsa-let-7a	hsa-let-7a-3	22	21352471
hsa-let-7a*	hsa-let-7a-1	9	21352471
hsa-let-7a*	hsa-let-7a-3	22	21352471
hsa-let-7b	hsa-let-7b	22	21352471
hsa-let-7b*	hsa-let-7b	22	21352471
hsa-let-7c	hsa-let-7c	21	21352471
hsa-let-7c*	hsa-let-7c	21	21352471
hsa-let-7d	hsa-let-7d	9	21352471
hsa-let-7d*	hsa-let-7d	9	21352471
hsa-let-7e	hsa-let-7e	19	19699171
hsa-let-7e	hsa-let-7e	19	21352471
hsa-let-7e*	hsa-let-7e	19	19699171
hsa-let-7e*	hsa-let-7e	19	21352471
hsa-let-7f	hsa-let-7f-1	9	21352471
hsa-let-7f	hsa-let-7f-2	X	21352471
hsa-let-7f-1*	hsa-let-7f-1	9	21352471
hsa-let-7f-2*	hsa-let-7f-2	X	21352471
hsa-let-7g	hsa-let-7g	3	21352471
hsa-let-7g*	hsa-let-7g	3	21352471
hsa-let-7i	hsa-let-7i	12	21352471
hsa-let-7i*	hsa-let-7i	12	21352471
hsa-miR-106b	hsa-mir-106b	7	18728182
hsa-miR-106b*	hsa-mir-106b	7	18728182
hsa-miR-125b	hsa-mir-125b-1	11	19699171
hsa-miR-125b	hsa-mir-125b-2	21	19699171
hsa-miR-146a	hsa-mir-146a	5	20850013
hsa-miR-146a	hsa-mir-146a	5	19635561
hsa-miR-146a*	hsa-mir-146a	5	20850013
hsa-miR-146a*	hsa-mir-146a	5	19635561
hsa-miR-146b-3p	hsa-mir-146b	10	19635561
hsa-miR-146b-5p	hsa-mir-146b	10	19635561
hsa-miR-155	hsa-mir-155	21	21355095
hsa-miR-155	hsa-mir-155	21	21097505
hsa-miR-155	hsa-mir-155	21	20937844
hsa-miR-155	hsa-mir-155	21	20354188
hsa-miR-155	hsa-mir-155	21	19699171
hsa-miR-155	hsa-mir-155	21	19651781
hsa-miR-155	hsa-mir-155	21	19144316
hsa-miR-155*	hsa-mir-155	21	21355095
hsa-miR-155*	hsa-mir-155	21	21097505
hsa-miR-155*	hsa-mir-155	21	20937844
hsa-miR-155*	hsa-mir-155	21	20354188
hsa-miR-155*	hsa-mir-155	21	19699171
hsa-miR-155*	hsa-mir-155	21	19651781
hsa-miR-155*	hsa-mir-155	21	19144316
hsa-miR-17	hsa-mir-17	13	18728182
hsa-miR-17	hsa-mir-17	13	17934639
hsa-miR-17*	hsa-mir-17	13	18728182
hsa-miR-17*	hsa-mir-17	13	17934639
hsa-miR-181a	hsa-mir-181a-2	9	18728182
hsa-miR-181a	hsa-mir-181a-1	1	18728182
hsa-miR-181a	hsa-mir-181a-2	9	21352471
hsa-miR-181a	hsa-mir-181a-1	1	21352471
hsa-miR-181a*	hsa-mir-181a-1	1	21352471
hsa-miR-181a-2*	hsa-mir-181a-2	9	21352471
hsa-miR-181b	hsa-mir-181b-1	1	18728182
hsa-miR-181b	hsa-mir-181b-2	9	18728182
hsa-miR-181b	hsa-mir-181b-1	1	17934639
hsa-miR-181b	hsa-mir-181b-2	9	17934639
hsa-miR-181b	hsa-mir-181b-1	1	21352471
hsa-miR-181b	hsa-mir-181b-2	9	21352471
hsa-miR-181c	hsa-mir-181c	19	19699171
hsa-miR-181c	hsa-mir-181c	19	21352471
hsa-miR-181c*	hsa-mir-181c	19	19699171
hsa-miR-181c*	hsa-mir-181c	19	21352471
hsa-miR-181d	hsa-mir-181d	19	21352471
hsa-miR-195	hsa-mir-195	17	17934639
hsa-miR-195*	hsa-mir-195	17	17934639
hsa-miR-19a	hsa-mir-19a	13	18728182
hsa-miR-19a*	hsa-mir-19a	13	18728182
hsa-miR-19b	hsa-mir-19b-1	13	18728182
hsa-miR-19b	hsa-mir-19b-2	X	18728182
hsa-miR-204	hsa-mir-204	9	17934639
hsa-miR-21	hsa-mir-21	17	18728182
hsa-miR-21*	hsa-mir-21	17	18728182
hsa-miR-218	hsa-mir-218-1	4	17934639
hsa-miR-218	hsa-mir-218-2	5	17934639
hsa-miR-221	hsa-mir-221	X	21355095
hsa-miR-221*	hsa-mir-221	X	21355095
hsa-miR-25	hsa-mir-25	7	18728182
hsa-miR-25*	hsa-mir-25	7	18728182
hsa-miR-29a	hsa-mir-29a	7	17934639
hsa-miR-29a*	hsa-mir-29a	7	17934639
hsa-miR-29c	hsa-mir-29c	1	17934639
hsa-miR-29c*	hsa-mir-29c	1	17934639
hsa-miR-30b	hsa-mir-30b	8	17934639
hsa-miR-30b*	hsa-mir-30b	8	17934639
hsa-miR-32	hsa-mir-32	9	18728182
hsa-miR-32*	hsa-mir-32	9	18728182
hsa-miR-331-3p	hsa-mir-331	12	17934639
hsa-miR-331-5p	hsa-mir-331	12	17934639
hsa-miR-34a	hsa-mir-34a	1	17934639
hsa-miR-34a*	hsa-mir-34a	1	17934639
hsa-miR-92a	hsa-mir-92a-1	13	17934639
hsa-miR-92a	hsa-mir-92a-2	X	17934639
hsa-miR-93	hsa-mir-93	7	18728182
hsa-miR-93*	hsa-mir-93	7	18728182

Cis-Nats regulation

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Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for SOCS1

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics