AutismKB 2.0

Annotation Detail for PDE5A


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Basic Information Top
Gene Symbol:PDE5A ( CGB-PDE,CN5A,PDE5 )
Gene Full Name: phosphodiesterase 5A, cGMP-specific
Band: 4q26
Quick LinksEntrez ID:8654; OMIM: 603310; Uniprot ID:PDE5A_HUMAN; ENSEMBL ID: ENSG00000138735; HGNC ID: 8784
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
102Phosphoserine (Potential).
Location(AA) Modifications Resource
102Phosphoserine (Potential).Swiss-Prot 53.0
102Phosphoserine (PKA
Location(AA) Modification Resource
50Phosphothreonine(PKA)HMM predict
92Phosphoserine(IKK)HMM predict
96PhosphothreonineHMM predict
96Phosphothreonine(CDK)HMM predict
96Phosphothreonine(CDC2)HMM predict
96Phosphothreonine(MAPK)HMM predict
102Phosphoserine(CAMK2)HMM predict
102Phosphoserine(PKG)HMM predict
102Phosphoserine(PKA)HMM predict
102PhosphoserineHMM predict
137Phosphothreonine(MAPK)HMM predict
246Phosphotyrosine(Syk)HMM predict
454Phosphothreonine(CDC2)HMM predict
509Phosphotyrosine(EGFR)HMM predict
509Phosphotyrosine(SRC)HMM predict
553Phosphothreonine(PKC)HMM predict
661N-linkedHMM predict
662N-linkedHMM predict
705Phosphoserine(CK2)HMM predict
712Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001083
  • Location:chr4 120634998-120769428
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 120769115 120770035 920 147
KLF4 hESGSE17917 120769853 120770265 412 631
TFAP2C MCF7GSE21234 120769634 120770043 409 410
hScc1 BcellGSE12603 120769048 120770072 1024 132
hScc1 CdLSGSE12603 120769263 120770035 772 221
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
hScc1 G2GSE9613 120767594 120770072 2478 0
p130 shRbSenescentGSE19898 120768446 120768886 440 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-155 hsa-mir-155 21 18790048
hsa-miR-155* hsa-mir-155 21 18790048
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
20134 HTC chr4 120767400 120830782 184 mRNA PDE5A chr4 120773153 120907584Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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