AutismKB 2.0

Annotation Detail for TNKS


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Basic Information Top
Gene Symbol:TNKS ( PARP-5a,PARP5A,PARPL,TIN1,TINF1,TNKS1,pART5 )
Gene Full Name: tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
Band: 8p23.1
Quick LinksEntrez ID:8658; OMIM: 603303; Uniprot ID:TNKS1_HUMAN; ENSEMBL ID: ENSG00000173273; HGNC ID: 11941
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
365Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
7Phosphoserine(ATM)HMM predict
7Phosphoserine(CK1)HMM predict
25O-linkedHMM predict
36O-linkedHMM predict
44O-linkedHMM predict
47O-linkedHMM predict
47Phosphoserine(CDK)HMM predict
47Phosphoserine(CDC2)HMM predict
47Phosphoserine(IKK)HMM predict
47Phosphoserine(MAPK)HMM predict
58Phosphoserine(CDK)HMM predict
80Phosphoserine(CDC2)HMM predict
80O-linkedHMM predict
87O-linkedHMM predict
88Phosphoserine(IKK)HMM predict
92O-linkedHMM predict
94O-linkedHMM predict
94O-linkedHMM predict
98O-linkedHMM predict
109O-linkedHMM predict
109O-linkedHMM predict
110O-linkedHMM predict
111O-linkedHMM predict
112O-linkedHMM predict
123O-linkedHMM predict
123O-linkedHMM predict
125Phosphoserine(IKK)HMM predict
126N-linkedHMM predict
127N-linkedHMM predict
128Phosphoserine(IKK)HMM predict
128Phosphoserine(CDC2)HMM predict
130Phosphoserine(CK2)HMM predict
130O-linkedHMM predict
130O-linkedHMM predict
133Phosphoserine(CK1)HMM predict
134Phosphoserine(CDC2)HMM predict
134Phosphoserine(IKK)HMM predict
136O-linkedHMM predict
136O-linkedHMM predict
142Phosphoserine(CDC2)HMM predict
142Phosphoserine(IKK)HMM predict
144Phosphoserine(CK1)HMM predict
144O-linkedHMM predict
145Phosphoserine(IKK)HMM predict
145Phosphoserine(MAPK)HMM predict
145Phosphoserine(CDC2)HMM predict
145Phosphoserine(ATM)HMM predict
160O-linkedHMM predict
161O-linkedHMM predict
282N-linkedHMM predict
356Phosphothreonine(MAPK)HMM predict
371Phosphothreonine(PKA)HMM predict
371Phosphothreonine(MAPK)HMM predict
371Phosphothreonine(CDK)HMM predict
477Phosphothreonine(CDK)HMM predict
477Phosphothreonine(MAPK)HMM predict
485Phosphothreonine(PKC)HMM predict
615Phosphoserine(ATM)HMM predict
643Phosphothreonine(CDC2)HMM predict
672Phosphoserine(ATM)HMM predict
686Phosphothreonine(MAPK)HMM predict
686Phosphothreonine(CDK)HMM predict
837N-linkedHMM predict
839Phosphothreonine(CDK)HMM predict
839Phosphothreonine(MAPK)HMM predict
897N-linkedHMM predict
905Phosphothreonine(MAPK)HMM predict
938Phosphothreonine(MAPK)HMM predict
975O-linkedHMM predict
978Phosphoserine(MAPK)HMM predict
981Phosphoserine(IKK)HMM predict
982Phosphothreonine(MAPK)HMM predict
987Phosphoserine(IKK)HMM predict
994N-linkedHMM predict
1017Phosphothreonine(PKC)HMM predict
1118Phosphotyrosine(Syk)HMM predict
1118Phosphotyrosine(INSR)HMM predict
1118Phosphotyrosine(EGFR)HMM predict
1118Phosphotyrosine(SRC)HMM predict
1118SulfotyrosineHMM predict
1118Phosphotyrosine(Jak)HMM predict
1120Phosphoserine(CK2)HMM predict
1170Phosphoserine(CK1)HMM predict
1170Phosphoserine(CK2)HMM predict
1203Phosphotyrosine(INSR)HMM predict
1203SulfotyrosineHMM predict
1217N-linkedHMM predict
1219Phosphoserine(CK1)HMM predict
1222N-linkedHMM predict
1243Phosphotyrosine(Jak)HMM predict
1301Phosphotyrosine(EGFR)HMM predict
1317Phosphoserine(IKK)HMM predict
1319O-linkedHMM predict
1321O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003747
  • Location:chr8 9450854-9677264
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
E2F4 G0GSE7516 9450291 9450997 706 211
Fos K562GSE19551 9450295 9451122 827 146
LIN9 G0GSE7516 9450291 9451035 744 192
LIN9 SGSE7516 9449941 9451212 1271 278
Rb GrowingGSE19898 9450639 9450934 295 68
Rb QuiescentGSE19898 9450598 9450965 367 73
Rb SenescentGSE19898 9450446 9450933 487 165
p130 QuiescentGSE19898 9450250 9450923 673 268
p130 SenescentGSE19898 9450081 9451046 965 291
p130 shRbQuiescentGSE19898 9450192 9451085 893 216
p130 shRbSenescentGSE19898 9450202 9450937 735 285
p130 G0GSE7516 9450291 9451035 744 192
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 9694427 9694721 294 17310
hScc1 G2GSE9613 9694209 9694721 512 17201
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 9655551 9655678 127 0
CTCF CD4SISSRdata 9655551 9655678 127 0
CTCF G2GSE9613 9450823 9451478 655 0
ETS1 JurkatGSE17954 9450305 9451600 1295 0
FOXA1 DLD1GSE12801 9470309 9470540 231 0
GABP k562GSE8489 9451895 9452588 693 0
H3K4me3 colorectalcancer 9451674 9452217 543 0
H3ac HepG2E 9450997 9452253 1256 0
Oct1 H2O2-HelaGSE14283 9503734 9503764 30 0
Oct1 HelaGSE14283 9503734 9503764 30 0
Oct1 HelaGSE14283 9603887 9603921 34 0
P300 T30-glioblastomaGSE21026 9450227 9451957 1730 0
PHF8 HeLaGSE20725 9450340 9451684 1344 0
PHF8 Hs68plusFBSGSE20725 9450409 9451836 1427 0
hScc1 BcellGSE12603 9450654 9451478 824 0
hScc1 BcellGSE12603 9655466 9655729 263 0
hScc1 CdLSGSE12603 9655466 9655758 292 0
p130 QuiescentGSE19898 9450956 9451255 299 0
p130 QuiescentGSE19898 9451263 9451520 257 0
p130 QuiescentGSE19898 9451562 9451689 127 0
p130 SenescentGSE19898 9451052 9451739 687 0
p130 shRbQuiescentGSE19898 9451103 9451726 623 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
25049 mRNA TNKS chr8 9450854 9671801 189 EST chr8 9642927 9644096Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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