Annotation Detail for BECN1

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Basic Information Top

Gene Symbol:	BECN1 ( ATG6,VPS30,beclin1 )
Gene Full Name:	beclin 1, autophagy related
Band:	17q21.31
Quick Links	Entrez ID:8678; OMIM: 604378; Uniprot ID:BECN1_HUMAN; ENSEMBL ID: ENSG00000126581; HGNC ID: 1034
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:8 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:0 results

Location(AA)	Modification
29	Phosphothreonine.
30	Phosphoserine.
57	Phosphothreonine.
62	Phosphothreonine.
64	Phosphoserine.
90	Phosphoserine.
93	Phosphoserine.
96	Phosphoserine.

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_003766
Location:chr17 38215677-38229806
strand:-

Upstream the gene:6 results
Downstream the gene:0 results
Inside the gene:7 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	38229785	38230017	232	95
CTCF	CD4	SISSRdata	38229785	38230017	232	95
PHF8	293T	GSE20725	38229135	38230503	1368	13
hScc1	Bcell	GSE12603	38229630	38230007	377	12
p130	Quiescent	GSE19898	38229671	38230073	402	66
p130	shRbQuiescent	GSE19898	38229519	38230203	684	55

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	38229206	38230007	801	0
ETS1	Jurkat	GSE17954	38229038	38230187	1149	0
PHF8	HeLa	GSE20725	38229197	38230315	1118	0
hScc1	CdLS	GSE12603	38229565	38230007	442	0
p130	Quiescent	GSE19898	38229345	38229658	313	0
p130	Senescent	GSE19898	38229528	38230026	498	0
p130	shRbSenescent	GSE19898	38229391	38229988	597	0

Validated miRNA targets

miR Walk:2 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-30a	hsa-mir-30a	6	19535919
hsa-miR-30a*	hsa-mir-30a	6	19535919

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
11182	mRNA	FLJ40137	chr17	38204463	38216179	502	mRNA	BECN1	chr17	38215677	38229807	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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