AutismKB 2.0

Annotation Detail for RIPK1


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Basic Information Top
Gene Symbol:RIPK1 ( FLJ39204,RIP,RIP1 )
Gene Full Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
Band: 6p25.2
Quick LinksEntrez ID:8737; OMIM: 603453; Uniprot ID:RIPK1_HUMAN; ENSEMBL ID: ENSG00000137275; HGNC ID: 10019
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
6Phosphoserine.
20Phosphoserine; by autocatalysis
25Phosphoserine.
161Phosphoserine; by RIPK3 and autocatalysis
166Phosphoserine; by autocatalysis
303Phosphoserine.
320Phosphoserine.
333Phosphoserine.
384Phosphotyrosine.
387Phosphotyrosine.
389Phosphoserine.
547RIP homotypic interaction motif (RHIM).
Location(AA) Modifications Resource
384Phosphotyrosine.Swiss-Prot 53.0
384PhosphotyrosinePhospho.ELM 6.0
387Phosphotyrosine.Swiss-Prot 53.0
387PhosphotyrosinePhospho.ELM 6.0
389Phosphoserine.Swiss-Prot 53.0
389PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
88Phosphotyrosine(SRC)HMM predict
206Phosphothreonine(PKC)HMM predict
212Phosphotyrosine(SRC)HMM predict
296Phosphoserine(ATM)HMM predict
296Phosphoserine(CK1)HMM predict
296Phosphoserine(CK2)HMM predict
333Phosphoserine(IKK)HMM predict
335Phosphoserine(IKK)HMM predict
335Phosphoserine(PKG)HMM predict
335Phosphoserine(PKB)HMM predict
335Phosphoserine(CK1)HMM predict
342Phosphoserine(IKK)HMM predict
346Phosphoserine(ATM)HMM predict
416Phosphoserine(PKG)HMM predict
416Phosphoserine(PKA)HMM predict
426Phosphotyrosine(Syk)HMM predict
439Phosphotyrosine(INSR)HMM predict
440O-linkedHMM predict
441O-linkedHMM predict
453O-linkedHMM predict
510Phosphotyrosine(Jak)HMM predict
521O-linkedHMM predict
535N-linkedHMM predict
546Phosphotyrosine(INSR)HMM predict
578N-linkedHMM predict
659IsoleucineHMM predict
667Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003804
  • Location:chr6 3022056-3060417
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 3008444 3008889 445 13390
CTCF G2GSE9613 3009200 3009970 770 12472
CTCF G2GSE9613 3013330 3014101 771 8341
ETS1 JurkatGSE17954 3013337 3014667 1330 8055
H3ac HepG2E 3010001 3010168 167 11972
H3ac HepG2E 3010774 3011233 459 11053
H3ac HepG2E 3011573 3011747 174 10397
H3ac HepG2E 3013330 3013519 189 8632
H3ac HepG2E 3014381 3014927 546 7403
H3ac HepG2E 3015265 3015517 252 6666
H3ac HepG2E 3018974 3019286 312 2927
PHF8 HeLaGSE20725 3008827 3009954 1127 12666
PHF8 HeLaGSE20725 3013326 3014709 1383 8039
PHF8 Hs68minusFBSGSE20725 3008819 3009796 977 12749
PHF8 Hs68plusFBSGSE20725 3008767 3009816 1049 12765
PHF8 Hs68plusFBSGSE20725 3013256 3014890 1634 7984
Pol2 GM12878GSE19551 3013379 3014653 1274 8041
hScc1 BcellGSE12603 3008636 3010145 1509 12666
hScc1 BcellGSE12603 3010525 3010774 249 11407
hScc1 BcellGSE12603 3013367 3014042 675 8352
hScc1 CdLSGSE12603 3014002 3014666 664 7723
p130 shRbSenescentGSE19898 3008964 3009129 165 13010
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 3026905 3027307 402 0
CTCF G2GSE9613 3022394 3023058 664 0
CTCF G2GSE9613 3054432 3054607 175 0
TAF HelaGSE8489 3029528 3029798 270 0
TAF k562GSE8489 3036000 3039458 3458 0
hScc1 BcellGSE12603 3036000 3039458 3458 0
p63 keratinocytesGSE17611 3054727 3055629 902 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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