AutismKB 2.0

Annotation Detail for RIPK2


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Basic Information Top
Gene Symbol:RIPK2 ( CARD3,CARDIAK,CCK,GIG30,RICK,RIP2 )
Gene Full Name: receptor-interacting serine-threonine kinase 2
Band: 8q21.3
Quick LinksEntrez ID:8767; OMIM: 603455; Uniprot ID:RIPK2_HUMAN; ENSEMBL ID: ENSG00000104312; HGNC ID: 10020
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
168Phosphoserine.
174Phosphoserine.
176Phosphoserine.
178Phosphoserine.
332Phosphoserine.
345Phosphoserine.
349Phosphoserine.
355Phosphoserine.
360Phosphothreonine.
363Phosphoserine.
381Phosphotyrosine.
393Phosphoserine.
527Phosphoserine.
529Phosphoserine.
531Phosphoserine.
539Phosphoserine.
Location(AA) Modifications Resource
531Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
29Phosphoserine(PKB)HMM predict
29O-linkedHMM predict
31Phosphothreonine(PKC)HMM predict
33O-linkedHMM predict
100N-linkedHMM predict
104N-linkedHMM predict
137N-linkedHMM predict
176Phosphoserine(ATM)HMM predict
181Phosphoserine(CK1)HMM predict
181Phosphoserine(PKC)HMM predict
192Phosphotyrosine(INSR)HMM predict
198Phosphotyrosine(Syk)HMM predict
243Phosphoserine(ATM)HMM predict
257Phosphotyrosine(Jak)HMM predict
267Phosphoserine(CAMK2)HMM predict
345Phosphoserine(IKK)HMM predict
348Phosphoserine(CK1)HMM predict
357Phosphoserine(IKK)HMM predict
357Phosphoserine(ATM)HMM predict
357Phosphoserine(CDC2)HMM predict
360Phosphothreonine(PKC)HMM predict
361O-linkedHMM predict
363Phosphoserine(IKK)HMM predict
391N-linkedHMM predict
393Phosphoserine(IKK)HMM predict
474Phosphotyrosine(Syk)HMM predict
529Phosphoserine(CDK)HMM predict
529Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003821
  • Location:chr8 90839109-90872431
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 90838426 90838729 303 532
H3K4me3 colorectalcancer 90838103 90838657 554 730
H3ac HepG2E 90838103 90838657 554 730
PHF8 Hs68minusFBSGSE20725 90838231 90839666 1435 161
RARA MCF7GSE15244 90838002 90838691 689 763
RARG MCF7GSE15244 90838465 90838729 264 513
TAF HelaGSE8489 90838002 90838212 210 1003
TAF k562GSE8489 90838002 90838657 655 780
hScc1 CdLSGSE12603 90838766 90839373 607 40
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 90886031 90886454 423 13811
FOXA1 MCF7GSE15244 90887083 90887227 144 14724
GABP HelaGSE8489 90887585 90887788 203 15255
Oct1 H2O2-HelaGSE14283 90874226 90874258 32 1811
Oct1 HelaGSE14283 90874227 90874292 65 1828
RARA MCF7GSE15244 90885814 90886489 675 13720
RARA MCF7GSE15244 90887083 90887301 218 14761
RARG MCF7GSE15244 90885850 90886489 639 13738
STAT1 HeLaGSE12782 90877851 90879544 1693 6266
STAT1 HeLaGSE12783 90877851 90879535 1684 6262
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 90839036 90839739 703 0
ER E2-MCF7GSE14664 90870800 90870836 36 0
ER Fulvestrant-MCF7GSE14664 90868732 90868825 93 0
FOXA1 MCF7GSE15244 90840574 90841637 1063 0
GATA3 MCF7GSE15244 90840574 90841869 1295 0
H3K4me2 HCT116GSE10453 90840329 90840963 634 0
H3K4me3 colorectalcancer 90840539 90840822 283 0
H3ac HepG2E 90839563 90839986 423 0
H3ac HepG2E 90840329 90841869 1540 0
Oct1 HelaGSE14283 90860025 90860052 27 0
Oct1 HelaGSE14283 90868706 90868773 67 0
Oct1 HelaGSE14283 90869161 90869189 28 0
Oct1 HelaGSE14283 90870806 90870835 29 0
PHF8 HeLaGSE20725 90838319 90840011 1692 0
PolII HeLaGSE12783 90838240 90840212 1972 0
RARA MCF7GSE15244 90840329 90841804 1475 0
TAF HelaGSE8489 90840329 90840786 457 0
TAF k562GSE8489 90840329 90840786 457 0
hScc1 BcellGSE12603 90839072 90839495 423 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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