AutismKB 2.0

Annotation Detail for SIGLEC5


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Basic Information Top
Gene Symbol:SIGLEC5 ( CD170,CD33L2,OB-BP2,OBBP2,SIGLEC-5 )
Gene Full Name: sialic acid binding Ig-like lectin 5
Band: 19q13.41
Quick LinksEntrez ID:8778; OMIM: 604200; Uniprot ID:SIGL5_HUMAN; ENSEMBL ID: ENSG00000105501; HGNC ID: 10874
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
100N-linked (GlcNAc...) (Potential).
210N-linked (GlcNAc...) (Potential).
231N-linked (GlcNAc...) (Potential).
253N-linked (GlcNAc...) (Potential).
328N-linked (GlcNAc...) (Potential).
375N-linked (GlcNAc...) (Potential).
384N-linked (GlcNAc...) (Potential).
393N-linked (GlcNAc...) (Potential).
523ITIM motif.
547SLAM-like motif.
Location(AA) Modifications Resource
100N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
210N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
231N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
253N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
328N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
375N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
384N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
393N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
30Phosphothreonine(PKC)HMM predict
201Phosphothreonine(MAPK)HMM predict
223Phosphothreonine(PKC)HMM predict
231N-linkedHMM predict
253N-linkedHMM predict
289N-linkedHMM predict
295N-linkedHMM predict
306Phosphoserine(PKG)HMM predict
375N-linkedHMM predict
377Phosphoserine(ATM)HMM predict
384N-linkedHMM predict
386Phosphoserine(CDC2)HMM predict
393N-linkedHMM predict
422Phosphoserine(IKK)HMM predict
451S-palmitoylHMM predict
455S-palmitoylHMM predict
498Phosphoserine(CDC2)HMM predict
504O-linkedHMM predict
504Phosphoserine(IKK)HMM predict
522Phosphoserine(CAMK2)HMM predict
540Phosphoserine(CK1)HMM predict
544Phosphotyrosine(SRC)HMM predict
544PhosphotyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003830
  • Location:chr19 56806997-56825529
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 56832578 56832819 241 7169
CTCF CD4SISSRdata 56832578 56832819 241 7169
ER E2-MCF7GSE14664 56827031 56827073 42 1523
Oct1 HelaGSE14283 56827030 56827067 37 1519
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 56803008 56803306 298 3841
CTCF CD4SISSRdata 56803008 56803306 298 3841
CTCF G2GSE9613 56802867 56803290 423 3919
Myc K562GSE19551 56802989 56803440 451 3783
NRSF JurkatGSE13047 56802591 56803817 1226 3794
NRSF mAbJurkat 56798307 56799002 695 8343
NRSF mAbJurkat 56799644 56799936 292 7208
NRSF mAbJurkat 56800432 56803466 3034 5049
NRSF mAbJurkat 56804268 56804451 183 2638
NRSF mAbJurkat 56805528 56807507 1979 480
NRSF-mono JurkatQuESTdata 56802660 56803810 1150 3763
NRSF-poly JurkatQuESTdata 56802591 56803747 1156 3829
Oct1 HelaGSE14283 56803895 56803950 55 3075
STAT1 IFNSISSRdata 56803057 56803435 378 3752
hScc1 BcellGSE12603 56796109 56796885 776 10501
hScc1 BcellGSE12603 56802768 56803369 601 3929
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
NRSF mAbJurkat 56808591 56809042 451 0
NRSF mAbJurkat 56809671 56809943 272 0
NRSF mAbJurkat 56820053 56820518 465 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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