AutismKB 2.0

Annotation Detail for NRP1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NRP1 ( BDCA4,CD304,DKFZp686A03134,DKFZp781F1414,NP1,NRP,VEGF165R )
Gene Full Name: neuropilin 1
Band: 10p11.22
Quick LinksEntrez ID:8829; OMIM: 602069; Uniprot ID:NRP1_HUMAN; ENSEMBL ID: ENSG00000099250; HGNC ID: 8004
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
150N-linked (GlcNAc...).
261N-linked (GlcNAc...).
300N-linked (GlcNAc...) (Potential).
522N-linked (GlcNAc...).
612O-linked (Xyl...) (chondroitin sulfate);
612O-linked (Xyl...) (heparan sulfate);
842N-linked (GlcNAc...) (Potential).
920Phosphotyrosine.
Location(AA) Modifications Resource
150N-linked (GlcNAc...).Swiss-Prot 53.0
261N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
300N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
522N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
612O-linked (Xyl...) (chondroitin sulfate);alternate.Swiss-Prot 53.0
612O-linked (Xyl...) (heparan sulfate);alternate.Swiss-Prot 53.0
842N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
41Phosphoserine(MAPK)HMM predict
41O-linkedHMM predict
148Phosphoserine(ATM)HMM predict
150N-linkedHMM predict
151Phosphotyrosine(Abl)HMM predict
151Phosphotyrosine(INSR)HMM predict
160Phosphoserine(CDC2)HMM predict
322Phosphotyrosine(EGFR)HMM predict
354Phosphotyrosine(EGFR)HMM predict
386N-linkedHMM predict
522N-linkedHMM predict
546Phosphotyrosine(INSR)HMM predict
546Phosphotyrosine(EGFR)HMM predict
546Phosphotyrosine(Syk)HMM predict
548Phosphothreonine(CDK)HMM predict
594Phosphothreonine(CDK)HMM predict
594Phosphothreonine(CDC2)HMM predict
678Phosphoserine(IKK)HMM predict
710Phosphoserine(MAPK)HMM predict
714Phosphotyrosine(Abl)HMM predict
748Phosphotyrosine(EGFR)HMM predict
748Phosphotyrosine(INSR)HMM predict
830Phosphothreonine(MAPK)HMM predict
894Phosphoserine(PKG)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001024629
  • Location:chr10 33526555-33663455
  • strand:-
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 33545400 33546362 962 0
CBP T30-glioblastomaGSE21026 33566560 33567713 1153 0
CBP T30-glioblastomaGSE21026 33602054 33603322 1268 0
CBP T30-glioblastomaGSE21026 33619735 33620879 1144 0
CTCF CD4GSE12889 33659479 33659736 257 0
CTCF CD4SISSRdata 33659479 33659736 257 0
ER E2-MCF7GSE14664 33662651 33662688 37 0
ER Fulvestrant-MCF7GSE14664 33532238 33532288 50 0
ER MCF7GSE19013 33592732 33593953 1221 0
FOXA1 MCF7GSE15244 33581558 33582402 844 0
FOXA1 MCF7GSE15244 33592905 33593631 726 0
FOXA1 MCF7GSE15244 33619422 33620612 1190 0
FOXA1 MCF7GSE15244 33635252 33636148 896 0
FoxA1 MCF7MACSdata 33593217 33593534 317 0
FoxA1 MCF7MACSdata 33635744 33636046 302 0
GABP HelaGSE8489 33580483 33580792 309 0
H3K4me2 HCT116GSE10453 33662665 33663054 389 0
H3ac HepG2E 33662472 33663226 754 0
Oct1 H2O2-HelaGSE14283 33535351 33535388 37 0
Oct1 H2O2-HelaGSE14283 33567116 33567156 40 0
Oct1 H2O2-HelaGSE14283 33584758 33584786 28 0
Oct1 H2O2-HelaGSE14283 33639565 33639595 30 0
Oct1 H2O2-HelaGSE14283 33642181 33642208 27 0
Oct1 HelaGSE14283 33532239 33532277 38 0
Oct1 HelaGSE14283 33535350 33535388 38 0
Oct1 HelaGSE14283 33634454 33634482 28 0
Oct1 HelaGSE14283 33639559 33639598 39 0
P300 T0-glioblastomaGSE21026 33592728 33593675 947 0
P300 T30-glioblastomaGSE21026 33545293 33546437 1144 0
P300 T30-glioblastomaGSE21026 33566479 33567938 1459 0
P300 T30-glioblastomaGSE21026 33592491 33593742 1251 0
P300 T30-glioblastomaGSE21026 33601813 33603248 1435 0
P300 T30-glioblastomaGSE21026 33619213 33621476 2263 0
RARA MCF7GSE15244 33545727 33546246 519 0
RARA MCF7GSE15244 33566913 33567398 485 0
RARA MCF7GSE15244 33581558 33582521 963 0
RARA MCF7GSE15244 33592593 33593730 1137 0
RARA MCF7GSE15244 33594096 33594445 349 0
RARA MCF7GSE15244 33600762 33601581 819 0
RARA MCF7GSE15244 33602244 33603456 1212 0
RARA MCF7GSE15244 33619314 33620685 1371 0
RARA MCF7GSE15244 33621330 33621582 252 0
RARG MCF7GSE15244 33545682 33546246 564 0
RARG MCF7GSE15244 33566913 33567269 356 0
RARG MCF7GSE15244 33581558 33582402 844 0
RARG MCF7GSE15244 33592454 33593730 1276 0
RARG MCF7GSE15244 33594096 33594445 349 0
RARG MCF7GSE15244 33600869 33601581 712 0
RARG MCF7GSE15244 33619230 33620685 1455 0
RARG MCF7GSE15244 33624179 33624320 141 0
TFAP2C MCF7GSE21234 33538645 33539064 419 0
TFAP2C MCF7GSE21234 33619942 33620606 664 0
hScc1 BcellGSE12603 33659261 33659850 589 0
hScc1 CdLSGSE12603 33659194 33660139 945 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1176 Unknown pSILAC miR-1 NRP1 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000099250 n_a n_a n_a "epithelium, squamous cell, lymphocyte, macrophage, muscle cell" "benign tumour, malignant tumour, carcinoma, sarcoma"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
2993 EST chr10 33497314 33508078 208 mRNA NRP1 chr10 33506432 33663476Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved