Annotation Detail for HDAC3

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Basic Information Top

Gene Symbol:	HDAC3 ( HD3,RPD3,RPD3-2 )
Gene Full Name:	histone deacetylase 3
Band:	5q31.3
Quick Links	Entrez ID:8841; OMIM: 605166; Uniprot ID:HDAC3_HUMAN; ENSEMBL ID: ENSG00000171720; HGNC ID: 4854
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:1 results
Experimental PTM Sites from dbPTM:1 results
Predicted PTM Sites by profile HMM from dbPTM:12 results

Location(AA)	Modification
424	Phosphoserine.

Location(AA)	Modification	Resource
66	Sulfotyrosine	HMM predict
66	Phosphotyrosine(EGFR)	HMM predict
74	Phosphoserine(CDC2)	HMM predict
74	Phosphoserine(IKK)	HMM predict
189	Phosphothreonine(PKC)	HMM predict
216	Phosphotyrosine(INSR)	HMM predict
232	Phosphotyrosine(Syk)	HMM predict
298	Phosphotyrosine(INSR)	HMM predict
320	Phosphoserine(CK1)	HMM predict
403	N-linked	HMM predict
404	Phosphotyrosine(SRC)	HMM predict
404	Phosphotyrosine(Syk)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_003883
Location:chr5 140980626-140996595
strand:-

Upstream the gene:1 results
Downstream the gene:1 results
Inside the gene:9 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	140996110	140997155	1045	37

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
USF1	HepG2	E	140979009	140980984	1975	630

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	140984828	140985094	266	0
ER	E2-MCF7	GSE14664	140993330	140993368	38	0
ER	Fulvestrant-MCF7	GSE14664	140993330	140993367	37	0
H3K4me2	HCT116	GSE10453	140995659	140996244	585	0
H3K4me3	colorectal	cancer	140995178	140995339	161	0
H3K4me3	colorectal	cancer	140995659	140996315	656	0
H3ac	HepG2	E	140993770	140995339	1569	0
H3ac	HepG2	E	140995659	140996315	656	0
Oct1	Hela	GSE14283	140988954	140989004	50	0

Validated miRNA targets

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
21590	EST		chr5	140978163	140986232	106	mRNA	HDAC3	chr5	140980626	140996596	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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