AutismKB 2.0

Annotation Detail for SPHK1


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Basic Information Top
Gene Symbol:SPHK1 ( SPHK )
Gene Full Name: sphingosine kinase 1
Band: 17q25.2
Quick LinksEntrez ID:8877; OMIM: 603730; Uniprot ID:SPHK1_HUMAN; ENSEMBL ID: ENSG00000176170; HGNC ID: 11240
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
155Nuclear export signal 1.
169Nuclear export signal 2.
193Phosphothreonine.
225Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
8MethylarginineHMM predict
137N-linkedHMM predict
165Phosphoserine(CAMK2)HMM predict
220O-linkedHMM predict
222Phosphothreonine(MAPK)HMM predict
225O-linkedHMM predict
225Phosphoserine(MAPK)HMM predict
225Phosphoserine(CDC2)HMM predict
318Phosphotyrosine(Syk)HMM predict
371SerineHMM predict
374ProlineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_021972
  • Location:chr17 71892296-71895535
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 71877800 71878338 538 14228
CTCF G2GSE9613 71887280 71887418 138 4948
CTCF G2GSE9613 71889014 71889149 135 3215
CTCF G2GSE9613 71891517 71892432 915 322
H3ac HepG2E 71887280 71887702 422 4806
H3ac HepG2E 71889485 71890131 646 2489
Oct1 H2O2-HelaGSE14283 71879089 71879128 39 13188
Oct1 HelaGSE14283 71879080 71879127 47 13193
P300 T30-glioblastomaGSE21026 71877848 71879245 1397 13750
RARA MCF7GSE15244 71877800 71878264 464 14265
RARG MCF7GSE15244 71877800 71878119 319 14337
Rb GrowingGSE19898 71878339 71878538 199 13858
Rb SenescentGSE19898 71878404 71878654 250 13768
hScc1 BcellGSE12603 71890494 71890860 366 1620
No data
No data
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
11674 mRNA SPHK1 chr17 71884336 71895536 7824 EST chr17 71839962 71892160 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018