AutismKB 2.0

Annotation Detail for HERC2


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Basic Information Top
Gene Symbol:HERC2 ( D15F37S1,DKFZp547P028,KIAA0393,SHEP1,jdf2,p528 )
Gene Full Name: hect domain and RLD 2
Band: 15q13.1
Quick LinksEntrez ID:8924; OMIM: 605837; Uniprot ID:HERC2_HUMAN; ENSEMBL ID: ENSG00000128731; HGNC ID: 4868
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1577Phosphoserine.
1588Phosphoserine.
1942Phosphoserine.
1944Phosphothreonine.
2454Phosphoserine.
2928Phosphoserine.
4810Phosphoserine.
4811Phosphoserine.
4814Phosphoserine.
4827Phosphothreonine.
Location(AA) Modifications Resource
1577Phosphoserine.Swiss-Prot 53.0
1577PhosphoserinePhospho.ELM 6.0
1588Phosphoserine.Swiss-Prot 53.0
1588PhosphoserinePhospho.ELM 6.0
2454PhosphoserinePhospho.ELM 6.0
2928Phosphoserine.Swiss-Prot 53.0
2928PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
71Phosphothreonine(PKC)HMM predict
132O-linkedHMM predict
155N-linkedHMM predict
182Phosphoserine(PKA)HMM predict
272Phosphothreonine(CDC2)HMM predict
368Phosphoserine(CDC2)HMM predict
368Phosphoserine(ATM)HMM predict
368Phosphoserine(IKK)HMM predict
414Phosphoserine(CDC2)HMM predict
414Phosphoserine(IKK)HMM predict
561O-linkedHMM predict
587Phosphoserine(CK2)HMM predict
587PhosphoserineHMM predict
634Phosphotyrosine(INSR)HMM predict
776C-linkedHMM predict
777Phosphoserine(CK2)HMM predict
810Phosphoserine(CAMK2)HMM predict
924Phosphoserine(CDC2)HMM predict
977N-linkedHMM predict
986Phosphothreonine(CDK)HMM predict
1023Phosphothreonine(PKC)HMM predict
1050Phosphoserine(CK1)HMM predict
1078Phosphoserine(CK2)HMM predict
1109Phosphoserine(IKK)HMM predict
1242Phosphoserine(IKK)HMM predict
1297Phosphoserine(IKK)HMM predict
1327Phosphoserine(CDC2)HMM predict
1327Phosphoserine(CDK)HMM predict
1366O-linkedHMM predict
1366Phosphoserine(CDC2)HMM predict
1370Phosphothreonine(CDC2)HMM predict
1370Phosphothreonine(MAPK)HMM predict
1442S-palmitoylHMM predict
1443S-palmitoylHMM predict
1565Phosphoserine(CK2)HMM predict
1577Phosphoserine(CK2)HMM predict
1771N-linkedHMM predict
1773O-linkedHMM predict
1851Phosphothreonine(PKA)HMM predict
1942Phosphoserine(CK1)HMM predict
1942Phosphoserine(CK2)HMM predict
1948Phosphoserine(CK2)HMM predict
1953Phosphothreonine(PKC)HMM predict
2009O-linkedHMM predict
2011Phosphoserine(CDC2)HMM predict
2045Phosphoserine(ATM)HMM predict
2135O-linkedHMM predict
2237Phosphothreonine(PKA)HMM predict
2344Phosphoserine(ATM)HMM predict
2392Phosphoserine(CDC2)HMM predict
2392Phosphoserine(CDK)HMM predict
2431Phosphoserine(CK1)HMM predict
2431Phosphoserine(IKK)HMM predict
2436Phosphothreonine(CDC2)HMM predict
2454Phosphoserine(PKG)HMM predict
2454Phosphoserine(CDC2)HMM predict
2488N-linkedHMM predict
2523Phosphotyrosine(INSR)HMM predict
2524Phosphoserine(CK1)HMM predict
2524PhosphoserineHMM predict
2550Phosphothreonine(PKC)HMM predict
2551Phosphotyrosine(Syk)HMM predict
2559Phosphoserine(CK2)HMM predict
2563Phosphotyrosine(Syk)HMM predict
2579S-palmitoylHMM predict
2580S-palmitoylHMM predict
2634O-linkedHMM predict
2650Phosphoserine(PKG)HMM predict
2650Phosphoserine(IKK)HMM predict
2652Phosphothreonine(PKC)HMM predict
2717N-linkedHMM predict
2773Phosphoserine(ATM)HMM predict
2790N-linkedHMM predict
2796N-linkedHMM predict
2814Phosphoserine(ATM)HMM predict
2869N-linkedHMM predict
2887Phosphotyrosine(INSR)HMM predict
2956Phosphothreonine(PKC)HMM predict
3014Phosphotyrosine(INSR)HMM predict
3098Phosphothreonine(PKC)HMM predict
3111Phosphoserine(IKK)HMM predict
3115O-linkedHMM predict
3115Phosphothreonine(CK2)HMM predict
3136N-linkedHMM predict
3291N-linkedHMM predict
3297N-linkedHMM predict
3301Phosphothreonine(PKA)HMM predict
3301Phosphothreonine(PKC)HMM predict
3321Phosphoserine(ATM)HMM predict
3360Phosphoserine(IKK)HMM predict
3480Phosphothreonine(MAPK)HMM predict
3482O-linkedHMM predict
3485O-linkedHMM predict
3485Phosphothreonine(MAPK)HMM predict
3485Phosphothreonine(CDK)HMM predict
3492O-linkedHMM predict
3608Phosphoserine(PKG)HMM predict
3609Phosphoserine(PKA)HMM predict
3609Phosphoserine(ATM)HMM predict
3620Phosphotyrosine(Syk)HMM predict
3624O-linkedHMM predict
3625Phosphoserine(IKK)HMM predict
3629O-linkedHMM predict
3807Phosphoserine(CAMK2)HMM predict
3807Phosphoserine(IKK)HMM predict
3984Phosphothreonine(PKC)HMM predict
4007Phosphotyrosine(INSR)HMM predict
4024Phosphoserine(IKK)HMM predict
4075N-linkedHMM predict
4103O-linkedHMM predict
4107O-linkedHMM predict
4126Phosphoserine(CK2)HMM predict
4126Phosphoserine(ATM)HMM predict
4128Phosphoserine(CAMK2)HMM predict
4174Phosphotyrosine(INSR)HMM predict
4271SulfotyrosineHMM predict
4319O-linkedHMM predict
4363S-palmitoylHMM predict
4372Phosphoserine(CK2)HMM predict
4393Phosphoserine(ATM)HMM predict
4428Phosphoserine(PKG)HMM predict
4548Phosphoserine(IKK)HMM predict
4677Phosphoserine(IKK)HMM predict
4783Phosphotyrosine(Jak)HMM predict
4793Phosphothreonine(CK2)HMM predict
4796Phosphotyrosine(INSR)HMM predict
4796Phosphotyrosine(Syk)HMM predict
4810Phosphoserine(CK2)HMM predict
4810Phosphoserine(IKK)HMM predict
4811Phosphoserine(CK1)HMM predict
4811Phosphoserine(ATM)HMM predict
4814Phosphoserine(CK1)HMM predict
4814Phosphoserine(CK2)HMM predict
4814Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004667
  • Location:chr15 26029784-26240889
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 26252572 26252723 151 11758
hScc1 BcellGSE12603 26252351 26252723 372 11648
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 26025116 26025710 594 4372
hScc1 BcellGSE12603 26026078 26026427 349 3532
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 26032693 26033000 307 0
CTCF G2GSE9613 26035976 26036428 452 0
CTCF G2GSE9613 26040488 26040857 369 0
CTCF G2GSE9613 26041315 26042503 1188 0
CTCF G2GSE9613 26050147 26050504 357 0
CTCF G2GSE9613 26063802 26063976 174 0
CTCF G2GSE9613 26067762 26068174 412 0
CTCF G2GSE9613 26122320 26122686 366 0
CTCF G2GSE9613 26124292 26124852 560 0
CTCF G2GSE9613 26133044 26133298 254 0
CTCF G2GSE9613 26136057 26136298 241 0
CTCF G2GSE9613 26240464 26241065 601 0
H3K4me3 colorectalcancer 26230229 26230440 211 0
H3K4me3 colorectalcancer 26239722 26240804 1082 0
H3ac HepG2E 26234431 26234776 345 0
H3ac HepG2E 26237376 26238012 636 0
H3ac HepG2E 26239164 26240619 1455 0
LIN9 G0GSE7516 26234506 26234776 270 0
Myc K562GSE19551 26213336 26213605 269 0
Nanog ESGSE20650 26210946 26211370 424 0
Oct1 H2O2-HelaGSE14283 26043179 26043207 28 0
Oct1 H2O2-HelaGSE14283 26233758 26233801 43 0
Oct1 H2O2-HelaGSE14283 26240490 26240517 27 0
Oct1 HelaGSE14283 26095482 26095553 71 0
Oct1 HelaGSE14283 26095638 26095685 47 0
Oct1 HelaGSE14283 26233759 26233801 42 0
RARA MCF7GSE15244 26121523 26122957 1434 0
Rb SenescentGSE19898 26110768 26110922 154 0
TAF HelaGSE8489 26135515 26136298 783 0
TAF HelaGSE8489 26234397 26234990 593 0
TFAP2C MCF7GSE21234 26070547 26070919 372 0
TFAP2C MCF7GSE21234 26122236 26122633 397 0
c MYCMCF7 26067361 26069555 2194 0
hScc1 BcellGSE12603 26030384 26030604 220 0
hScc1 BcellGSE12603 26032776 26033186 410 0
hScc1 BcellGSE12603 26040452 26040881 429 0
hScc1 BcellGSE12603 26041315 26041489 174 0
hScc1 BcellGSE12603 26042078 26042503 425 0
hScc1 BcellGSE12603 26050111 26050469 358 0
hScc1 BcellGSE12603 26064233 26064630 397 0
hScc1 BcellGSE12603 26124216 26124747 531 0
hScc1 BcellGSE12603 26132792 26133435 643 0
hScc1 BcellGSE12603 26137154 26137439 285 0
hScc1 BcellGSE12603 26138992 26139524 532 0
hScc1 BcellGSE12603 26168698 26169068 370 0
hScc1 BcellGSE12603 26234542 26234776 234 0
hScc1 BcellGSE12603 26239999 26241206 1207 0
hScc1 CdLSGSE12603 26124292 26124782 490 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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