AutismKB 2.0

Annotation Detail for HERC1


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Basic Information Top
Gene Symbol:HERC1 ( p532,p619 )
Gene Full Name: hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
Band: 15q22.31
Quick LinksEntrez ID:8925; OMIM: 605109; Uniprot ID:HERC1_HUMAN; ENSEMBL ID: ENSG00000103657; HGNC ID: 4867
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1428Phosphoserine.
1502Phosphoserine.
1510Phosphoserine.
1512Phosphoserine.
1514Phosphoserine.
1517Phosphoserine.
1521Phosphoserine.
2701Phosphothreonine.
2706Phosphoserine.
2709Phosphothreonine.
2710Phosphoserine.
2747Phosphoserine.
3628Phosphothreonine.
3631Phosphoserine.
3643Phosphothreonine.
4786Phosphothreonine.
4790Phosphoserine.
Location(AA) Modifications Resource
No data
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003922
  • Location:chr15 61687870-61913139
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Gata1 K562GSE18868 61913313 61914142 829 588
Gata2 K562GSE18868 61913211 61914046 835 489
Oct1 H2O2-HelaGSE14283 61915927 61915957 30 2803
Oct1 HelaGSE14283 61915927 61915957 30 2803
PHF8 HeLaGSE20725 61912616 61914018 1402 178
Rb QuiescentGSE19898 61913225 61913462 237 204
Rb SenescentGSE19898 61913041 61913536 495 149
TAF HelaGSE8489 61912784 61914273 1489 389
p130 QuiescentGSE19898 61913110 61913583 473 207
p130 SenescentGSE19898 61913077 61913402 325 100
p130 SenescentGSE19898 61913487 61913778 291 493
p130 shRbQuiescentGSE19898 61913161 61913831 670 357
p130 shRbSenescentGSE19898 61913162 61913638 476 261
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 61689359 61689824 465 0
CTCF CD4GSE12889 61831338 61831617 279 0
CTCF CD4SISSRdata 61689359 61689824 465 0
CTCF CD4SISSRdata 61831338 61831617 279 0
CTCF HelaGSE12889 61689471 61689679 208 0
CTCF G2GSE9613 61689490 61690046 556 0
CTCF G2GSE9613 61693241 61693704 463 0
CTCF G2GSE9613 61705171 61705314 143 0
CTCF G2GSE9613 61912625 61913319 694 0
ER E2-MCF7GSE14664 61817507 61817605 98 0
ER Fulvestrant-MCF7GSE14664 61835065 61835101 36 0
ER Fulvestrant-MCF7GSE14664 61846411 61846457 46 0
ER MCF7GSE19013 61747340 61747878 538 0
FoxA1 MCF7MACSdata 61757032 61757379 347 0
H3ac HepG2E 61911164 61912385 1221 0
KLF4 hESGSE17917 61893604 61893760 156 0
Oct1 H2O2-HelaGSE14283 61745124 61745161 37 0
Oct1 H2O2-HelaGSE14283 61765236 61765274 38 0
Oct1 H2O2-HelaGSE14283 61850612 61850644 32 0
Oct1 H2O2-HelaGSE14283 61909650 61909687 37 0
Oct1 HelaGSE14283 61700182 61700251 69 0
Oct1 HelaGSE14283 61745124 61745173 49 0
Oct1 HelaGSE14283 61765237 61765274 37 0
Oct1 HelaGSE14283 61835029 61835098 69 0
Oct1 HelaGSE14283 61835476 61835509 33 0
Oct1 HelaGSE14283 61846411 61846465 54 0
Oct1 HelaGSE14283 61850612 61850642 30 0
Oct1 HelaGSE14283 61877390 61877418 28 0
Oct1 HelaGSE14283 61909650 61909687 37 0
Oct4 hESGSE17917 61689449 61689715 266 0
Rb GrowingGSE19898 61689484 61689637 153 0
Sox2 hESGSE18292 61689499 61689701 202 0
Stat6 IL-4-hr4GSE17850 61897384 61897877 493 0
USF2 HepG2E 61731597 61731877 280 0
VDR GM10855-stimGSE22484 61756838 61757967 1129 0
hScc1 BcellGSE12603 61689295 61689715 420 0
hScc1 BcellGSE12603 61831369 61831884 515 0
hScc1 BcellGSE12603 61912451 61913442 991 0
hScc1 CdLSGSE12603 61831229 61831812 583 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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