Annotation Detail for CCND2

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Basic Information Top

Gene Symbol:	CCND2 ( KIAK0002,MGC102758 )
Gene Full Name:	cyclin D2
Band:	12p13.32
Quick Links	Entrez ID:894; OMIM: 123833; Uniprot ID:CCND2_HUMAN; ENSEMBL ID: ENSG00000118971; HGNC ID: 1583
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

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PTM Sites from Uniprot:0 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:5 results

No data

Location(AA)	Modification	Resource
155	Phosphothreonine(MAPK)	HMM predict
269	Phosphoserine(CK1)	HMM predict
269	Phosphoserine(CK2)	HMM predict
271	Phosphoserine(CK2)	HMM predict
280	Phosphothreonine(MAPK)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_001759
Location:chr12 4253198-4284776
strand:+

Upstream the gene:8 results
Downstream the gene:4 results
Inside the gene:15 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
H3K4me3	colorectal	cancer	4247930	4248556	626	4956
Oct1	H2O2-Hela	GSE14283	4242598	4242626	28	10587
Oct1	Hela	GSE14283	4247304	4247334	30	5880
hScc1	Bcell	GSE12603	4248241	4249604	1363	4276
hScc1	Bcell	GSE12603	4251256	4251907	651	1617
hScc1	Bcell	GSE12603	4252220	4252581	361	798
hScc1	CdLS	GSE12603	4247820	4249640	1820	4469
hScc1	CdLS	GSE12603	4251007	4251668	661	1861

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
NRSF	pAb	Jurkat	4287471	4288096	625	3007
TFAP2C	MCF7	GSE21234	4287225	4287847	622	2760
hScc1	Bcell	GSE12603	4287251	4287681	430	2690
hScc1	G2	GSE9613	4287141	4287681	540	2635

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	CD4	GSE12889	4256349	4256666	317
CTCF	CD4	SISSRdata	4256349	4256666	317
CTCF	Hela	GSE12889	4256408	4256771	363
ER	Fulvestrant-MCF7	GSE14664	4272520	4272557	37
FOXA1	DLD1	GSE12801	4258494	4258976	482
FOXA1	MCF7	GSE15244	4256193	4256765	572
FOXA1	MCF7	GSE15244	4265840	4266014	174
Oct1	Hela	GSE14283	4265231	4265263	32
Oct1	Hela	GSE14283	4272526	4272571	45
Pol2	GM12878	GSE19551	4252800	4254434	1634
RARG	MCF7	GSE15244	4256193	4256807	614
RARG	MCF7	GSE15244	4265840	4266014	174
hScc1	Bcell	GSE12603	4256153	4257016	863
hScc1	CdLS	GSE12603	4256077	4257355	1278
hScc1	G2	GSE9613	4256240	4256882	642

Validated miRNA targets

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miR Walk:60 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7a	hsa-let-7a-1	9	20418948
hsa-let-7a	hsa-let-7a-2	11	20418948
hsa-let-7a	hsa-let-7a-3	22	20418948
hsa-let-7a*	hsa-let-7a-1	9	20418948
hsa-let-7a*	hsa-let-7a-3	22	20418948
hsa-let-7b	hsa-let-7b	22	20418948
hsa-let-7b*	hsa-let-7b	22	20418948
hsa-let-7c	hsa-let-7c	21	20418948
hsa-let-7c*	hsa-let-7c	21	20418948
hsa-let-7d	hsa-let-7d	9	20418948
hsa-let-7d*	hsa-let-7d	9	20418948
hsa-let-7e	hsa-let-7e	19	20418948
hsa-let-7e*	hsa-let-7e	19	20418948
hsa-let-7f	hsa-let-7f-1	9	20418948
hsa-let-7f	hsa-let-7f-2	X	20418948
hsa-let-7f-1*	hsa-let-7f-1	9	20418948
hsa-let-7f-2*	hsa-let-7f-2	X	20418948
hsa-let-7g	hsa-let-7g	3	20418948
hsa-let-7g*	hsa-let-7g	3	20418948
hsa-let-7i	hsa-let-7i	12	20418948
hsa-let-7i*	hsa-let-7i	12	20418948
hsa-miR-1	hsa-mir-1-2	18	20054351
hsa-miR-1	hsa-mir-1-1	20	20054351
hsa-miR-130b	hsa-mir-130b	22	21128228
hsa-miR-130b*	hsa-mir-130b	22	21128228
hsa-miR-132	hsa-mir-132	17	21128228
hsa-miR-132*	hsa-mir-132	17	21128228
hsa-miR-133a	hsa-mir-133a-1	18	20054351
hsa-miR-133a	hsa-mir-133a-2	20	20054351
hsa-miR-141	hsa-mir-141	12	18698484
hsa-miR-141*	hsa-mir-141	12	18698484
hsa-miR-144	hsa-mir-144	17	21128228
hsa-miR-144*	hsa-mir-144	17	21128228
hsa-miR-154	hsa-mir-154	14	21128228
hsa-miR-154*	hsa-mir-154	14	21128228
hsa-miR-15a	hsa-mir-15a	13	19549910
hsa-miR-15a*	hsa-mir-15a	13	19549910
hsa-miR-16	hsa-mir-16-1	13	19549910
hsa-miR-16	hsa-mir-16-2	3	19549910
hsa-miR-192	hsa-mir-192	11	21128228
hsa-miR-192*	hsa-mir-192	11	21128228
hsa-miR-198	hsa-mir-198	0	17849003
hsa-miR-200a	hsa-mir-200a	1	18698484
hsa-miR-200a*	hsa-mir-200a	1	18698484
hsa-miR-200b	hsa-mir-200b	1	20498046
hsa-miR-200b	hsa-mir-200b	1	18698484
hsa-miR-200b*	hsa-mir-200b	1	20498046
hsa-miR-200b*	hsa-mir-200b	1	18698484
hsa-miR-200c	hsa-mir-200c	12	18698484
hsa-miR-200c*	hsa-mir-200c	12	18698484
hsa-miR-205	hsa-mir-205	1	18698484
hsa-miR-206	hsa-mir-206	6	17849003
hsa-miR-214	hsa-mir-214	1	20498046
hsa-miR-214*	hsa-mir-214	1	20498046
hsa-miR-26a	hsa-mir-26a-1	3	19524505
hsa-miR-26a	hsa-mir-26a-2	12	19524505
hsa-miR-302b	hsa-mir-302b	4	18930031
hsa-miR-302b*	hsa-mir-302b	4	18930031
hsa-miR-345	hsa-mir-345	14	21128228
hsa-miR-429	hsa-mir-429	1	18698484

Cis-Nats regulation

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Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
5535	mRNA	CCND2	chr12	4253198	4284777	126	EST		chr12	4228193	4255611	Sense/Antisense (SA) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for CCND2

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics