AutismKB 2.0

Annotation Detail for TOP3B


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Basic Information Top
Gene Symbol:TOP3B ( FLJ39376 )
Gene Full Name: topoisomerase (DNA) III beta
Band: 22q11.22
Quick LinksEntrez ID:8940; OMIM: 603582; Uniprot ID:TOP3B_HUMAN; ENSEMBL ID: ENSG00000100038; HGNC ID: 11993
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
No data
Location(AA) Modification Resource
25Phosphoserine(CK1)HMM predict
55Phosphothreonine(PKA)HMM predict
63Phosphothreonine(PKC)HMM predict
83Phosphoserine(ATM)HMM predict
87Phosphothreonine(PKC)HMM predict
154Phosphoserine(PKB)HMM predict
154Phosphoserine(IKK)HMM predict
275N-linkedHMM predict
312Phosphoserine(CDC2)HMM predict
449Phosphoserine(CDC2)HMM predict
493Phosphotyrosine(INSR)HMM predict
578Phosphotyrosine(EGFR)HMM predict
612Phosphoserine(CDC2)HMM predict
655N-linkedHMM predict
684Phosphoserine(PKB)HMM predict
684Phosphoserine(PKA)HMM predict
767Phosphoserine(PKG)HMM predict
788PhosphoserineHMM predict
788Phosphoserine(CDK)HMM predict
788Phosphoserine(CDC2)HMM predict
837MethylarginineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003935
  • Location:chr22 20641403-20667146
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
GABP k562GSE8489 20668734 20669813 1079 2127
Nanog ESGSE20650 20667008 20667352 344 34
Oct4 hESGSE17917 20667142 20667366 224 108
P300 T0-glioblastomaGSE21026 20667003 20667374 371 42
P300 T30-glioblastomaGSE21026 20666880 20667568 688 78
PHF8 293TGSE20725 20666627 20667715 1088 25
PHF8 HeLaGSE20725 20666692 20667760 1068 80
Rb GrowingGSE19898 20667153 20667357 204 109
Rb QuiescentGSE19898 20667148 20667294 146 75
VDR GM10861-UnstimGSE22484 20666643 20667670 1027 10
VDR GM10861-stimGSE22484 20666769 20667686 917 81
p130 SenescentGSE19898 20667124 20667405 281 118
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 20656735 20657012 277 0
CTCF CD4SISSRdata 20656735 20657012 277 0
CTCF JurkatGSE12889 20656563 20656966 403 0
CTCF G2GSE9613 20647998 20648373 375 0
CTCF G2GSE9613 20653243 20653463 220 0
ETS1 JurkatGSE17954 20666585 20667549 964 0
GABP k562GSE8489 20664373 20665920 1547 0
GABP k562GSE8489 20666305 20667545 1240 0
H3K4me3 colorectalcancer 20666305 20666734 429 0
H3ac HepG2E 20666305 20666941 636 0
PHF8 Hs68plusFBSGSE20725 20666559 20667472 913 0
TFAP2C MCF7GSE21234 20643747 20644551 804 0
VDR GM10855-UnstimGSE22484 20666626 20667665 1039 0
hScc1 BcellGSE12603 20643774 20644064 290 0
hScc1 BcellGSE12603 20658284 20658465 181 0
hScc1 BcellGSE12603 20666907 20667302 395 0
p130 shRbSenescentGSE19898 20666781 20667439 658 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018