Annotation Detail for P4HA2

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Basic Information Top

Gene Symbol:	P4HA2 ( - )
Gene Full Name:	prolyl 4-hydroxylase, alpha polypeptide II
Band:	5q31.1
Quick Links	Entrez ID:8974; OMIM: 600608; Uniprot ID:P4HA2_HUMAN; ENSEMBL ID: ENSG00000072682; HGNC ID: 8547
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
115	N-linked (GlcNAc...) (Potential).
264	N-linked (GlcNAc...) (Potential).

Location(AA)	Modifications	Resource
115	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0
264	N-linked (GlcNAc...) (Potential).	Swiss-Prot 53.0

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	Hela	GSE12889	131543782	131544088	306	12270
CTCF	Hela	GSE12889	131553818	131554144	326	2224
CTCF	G2	GSE9613	131543733	131544179	446	12249
CTCF	G2	GSE9613	131544531	131544857	326	11511
CTCF	G2	GSE9613	131546177	131546440	263	9896
ETS1	Jurkat	GSE17954	131553539	131554246	707	2312
Fos	K562	GSE19551	131548083	131548595	512	7866
Gata1	K562	GSE18868	131541213	131541694	481	14751
Gata2	K562	GSE18868	131541239	131541736	497	14717
Oct1	Hela	GSE14283	131536577	131536654	77	19589
Oct1	Hela	GSE14283	131553563	131553592	29	2627
P300	T30-glioblastoma	GSE21026	131553578	131554273	695	2279
Rb	Growing	GSE19898	131553931	131554090	159	2194
STAT1	IFN	SISSRdata	131553750	131554311	561	2174
hScc1	Bcell	GSE12603	131543697	131544003	306	12355
hScc1	CdLS	GSE12603	131543803	131544179	376	12214
hScc1	G2	GSE9613	131543653	131545051	1398	11853

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	131567417	131567675	258
CTCF	G2	GSE9613	131576219	131576636	417
CTCF	G2	GSE9613	131578871	131579253	382
CTCF	G2	GSE9613	131580700	131580880	180
CTCF	G2	GSE9613	131581767	131582805	1038
CTCF	G2	GSE9613	131585550	131586096	546
CTCF	G2	GSE9613	131589255	131589606	351
H3K4me2	HCT116	GSE10453	131588346	131588918	572
H3K4me2	HCT116	GSE10453	131589954	131590531	577
Oct1	H2O2-Hela	GSE14283	131574754	131574787	33
Oct1	Hela	GSE14283	131574754	131574785	31
P300	T30-glioblastoma	GSE21026	131578612	131579716	1104
TFAP2C	MCF7	GSE21234	131578977	131579510	533
TFAP2C	MCF7	GSE21234	131588859	131589741	882

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
1259	Unknown	pSILAC	miR-30	P4HA2	down 50-25%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000072682		n_a	n_a	n_a	"epithelium, squamous cell, lymphoblast, lymphocyte, muscle cell, macrophage"	"benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
21441	EST		chr5	131548467	131556397	196	mRNA	P4HA2	chr5	131556201	131590458	Sense/Antisense (SA) pairs

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018