AutismKB 2.0

Annotation Detail for PLOD3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PLOD3 ( LH3 )
Gene Full Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
Band: 7q22.1
Quick LinksEntrez ID:8985; OMIM: 603066; Uniprot ID:PLOD3_HUMAN; ENSEMBL ID: ENSG00000106397; HGNC ID: 9083
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
63N-linked (GlcNAc...) (Potential).
548N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
63N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
548N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
63N-linkedHMM predict
100Phosphotyrosine(Syk)HMM predict
268Phosphotyrosine(INSR)HMM predict
367Phosphoserine(CDC2)HMM predict
367Phosphoserine(ATM)HMM predict
402Phosphothreonine(PKC)HMM predict
437Phosphotyrosine(Syk)HMM predict
438Phosphotyrosine(Syk)HMM predict
444Phosphotyrosine(INSR)HMM predict
444Phosphotyrosine(EGFR)HMM predict
686Phosphotyrosine(INSR)HMM predict
702Phosphoserine(CDC2)HMM predict
724O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001084
  • Location:chr7 100635978-100647730
  • strand:-
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
hScc1 BcellGSE12603 100633314 100634411 1097 2116
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 100636234 100636919 685 0
CTCF G2GSE9613 100637660 100638071 411 0
CTCF G2GSE9613 100638788 100638975 187 0
CTCF G2GSE9613 100641773 100642176 403 0
CTCF G2GSE9613 100645800 100646669 869 0
H3ac HepG2E 100645870 100647020 1150 0
PHF8 HeLaGSE20725 100646626 100648089 1463 0
Rb GrowingGSE19898 100646821 100647089 268 0
Rb QuiescentGSE19898 100646666 100646911 245 0
Rb SenescentGSE19898 100646761 100647125 364 0
Rb SenescentGSE19898 100647238 100647753 515 0
Rb shRbSenescenceGSE19898 100646867 100647047 180 0
Rb shRbSenescenceGSE19898 100647221 100647363 142 0
p130 QuiescentGSE19898 100647237 100647465 228 0
p130 SenescentGSE19898 100647219 100647499 280 0
p130 shRbSenescentGSE19898 100646656 100647160 504 0
p130 shRbSenescentGSE19898 100647213 100647388 175 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 19342589
hsa-let-7a hsa-let-7a-2 11 19342589
hsa-let-7a hsa-let-7a-3 22 19342589
hsa-let-7a* hsa-let-7a-1 9 19342589
hsa-let-7a* hsa-let-7a-3 22 19342589
hsa-let-7b hsa-let-7b 22 19342589
hsa-let-7b* hsa-let-7b 22 19342589
hsa-let-7c hsa-let-7c 21 19342589
hsa-let-7c* hsa-let-7c 21 19342589
hsa-let-7d hsa-let-7d 9 19342589
hsa-let-7d* hsa-let-7d 9 19342589
hsa-let-7e hsa-let-7e 19 19342589
hsa-let-7e* hsa-let-7e 19 19342589
hsa-let-7f hsa-let-7f-1 9 19342589
hsa-let-7f hsa-let-7f-2 X 19342589
hsa-let-7f-1* hsa-let-7f-1 9 19342589
hsa-let-7f-2* hsa-let-7f-2 X 19342589
hsa-let-7g hsa-let-7g 3 19342589
hsa-let-7g* hsa-let-7g 3 19342589
hsa-let-7i hsa-let-7i 12 19342589
hsa-let-7i* hsa-let-7i 12 19342589
hsa-miR-1 hsa-mir-1-2 18 15685193
hsa-miR-1 hsa-mir-1-1 20 15685193
hsa-miR-124 hsa-mir-124-1 8 15685193
hsa-miR-124 hsa-mir-124-2 8 15685193
hsa-miR-124 hsa-mir-124-3 20 15685193
hsa-miR-21 hsa-mir-21 17 19342589
hsa-miR-21* hsa-mir-21 17 19342589
hsa-miR-373 hsa-mir-373 19 15685193
hsa-miR-373* hsa-mir-373 19 15685193
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
249 Unknown MicroArray miR-124 PLOD3 n_a 15685193
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000106397 G1-to-S transition n_a n_a "epithelium, lymphoblast, lymphocyte, leukocyte, macrophage, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018