AutismKB 2.0

Annotation Detail for MPZL1


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Basic Information Top
Gene Symbol:MPZL1 ( FLJ21047,MPZL1b,PZR,PZR1b,PZRa,PZRb )
Gene Full Name: myelin protein zero-like 1
Band: 1q24.2
Quick LinksEntrez ID:9019; OMIM: 604376; Uniprot ID:MPZL1_HUMAN; ENSEMBL ID: ENSG00000197965; HGNC ID: 7226
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
50N-linked (GlcNAc...).
130N-linked (GlcNAc...) (Potential).
204Phosphoserine.
208Phosphoserine.
210Phosphoserine.
219Phosphoserine.
221Phosphoserine.
241Phosphotyrosine.
244ITIM motif 1.
260Phosphoserine.
263Phosphotyrosine.
266ITIM motif 2.
Location(AA) Modifications Resource
130N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
200PhosphotyrosinePhospho.ELM 6.0
210PhosphoserinePhospho.ELM 6.0
219PhosphoserinePhospho.ELM 6.0
241Phosphotyrosine.Swiss-Prot 53.0
241Phosphotyrosine (Src)Phospho.ELM 6.0
263Phosphotyrosine.Swiss-Prot 53.0
263Phosphotyrosine (Src)Phospho.ELM 6.0
Location(AA) Modification Resource
50N-linkedHMM predict
70O-linkedHMM predict
130N-linkedHMM predict
196Phosphoserine(PKG)HMM predict
196Phosphoserine(PKC)HMM predict
205O-linkedHMM predict
206O-linkedHMM predict
210PhosphoserineHMM predict
210Phosphoserine(CDC2)HMM predict
210Phosphoserine(CDK)HMM predict
219Phosphoserine(CDK)HMM predict
219Phosphoserine(CDC2)HMM predict
232Phosphoserine(CK1)HMM predict
247Phosphoserine(ATM)HMM predict
256N-linkedHMM predict
263Phosphotyrosine(Abl)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_024569
  • Location:chr1 165957831-166026681
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 165951401 165951677 276 6293
CTCF CD4SISSRdata 165951401 165951677 276 6293
CTCF G2GSE9613 165950294 165950428 134 7471
CTCF G2GSE9613 165951077 165951735 658 6426
CTCF G2GSE9613 165956845 165957937 1092 441
Fos K562GSE19551 165956759 165958212 1453 346
H3K4me3 colorectalcancer 165950539 165952116 1577 6504
H3K4me3 colorectalcancer 165957089 165957384 295 595
H3ac HepG2E 165951319 165952116 797 6114
H3ac HepG2E 165954749 165955639 890 2638
H3ac HepG2E 165956624 165957384 760 828
LIN9 SGSE7516 165950331 165950781 450 7276
PHF8 Hs68minusFBSGSE20725 165949881 165951001 1120 7391
PHF8 Hs68minusFBSGSE20725 165951083 165951650 567 6465
PHF8 Hs68plusFBSGSE20725 165949663 165951968 2305 7016
Pol3 GM12878GSE19551 165950126 165951009 883 7264
Pol3 GM12878GSE19551 165951060 165951820 760 6392
RARA MCF7GSE15244 165950539 165951735 1196 6695
TAF HelaGSE8489 165950560 165952116 1556 6494
TAF k562GSE8489 165950539 165952116 1577 6504
hScc1 BcellGSE12603 165956880 165957775 895 504
hScc1 CdLSGSE12603 165956671 165957278 607 857
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
P300 T30-glioblastomaGSE21026 166032686 166033896 1210 6610
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Fos K562GSE19551 165964677 165965168 491 0
H3K4me3 colorectalcancer 165958697 165959949 1252 0
H3ac HepG2E 165960236 165961087 851 0
Myc K562GSE19551 165992631 165993227 596 0
Nanog ESGSE20650 166005898 166006395 497 0
Nanog hESGSE18292 166006074 166006304 230 0
Oct1 HelaGSE14283 165967752 165967788 36 0
Oct1 HelaGSE14283 165987489 165987523 34 0
PHF8 HeLaGSE20725 165957210 165958891 1681 0
TAF k562GSE8489 165996377 165997925 1548 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
972 Unknown pSILAC miR-155 MPZL1 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000197965 n_a n_a n_a "epithelium, squamous cell, lymphocyte, muscle cell" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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