Annotation Detail for SOCS3

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Basic Information Top

Gene Symbol:	SOCS3 ( ATOD4,CIS3,Cish3,MGC71791,SOCS-3,SSI-3,SSI3 )
Gene Full Name:	suppressor of cytokine signaling 3
Band:	17q25.3
Quick Links	Entrez ID:9021; OMIM: 604176; Uniprot ID:SOCS3_HUMAN; ENSEMBL ID: ENSG00000184557; HGNC ID: 19391
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:0 results
Experimental PTM Sites from dbPTM:2 results
Predicted PTM Sites by profile HMM from dbPTM:12 results

No data

Location(AA)	Modification	Resource
31	Phosphotyrosine(SRC)	HMM predict
135	Phosphoserine(IKK)	HMM predict
135	O-linked	HMM predict
138	Phosphoserine(CDC2)	HMM predict
141	Phosphothreonine(CDK)	HMM predict
144	O-linked	HMM predict
145	O-linked	HMM predict
152	O-linked	HMM predict
159	Phosphoserine(CDC2)	HMM predict
159	Phosphoserine(CDK)	HMM predict
184	O-linked	HMM predict
204	Phosphotyrosine(EGFR)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_003955
Location:chr17 73864458-73867752
strand:-

Upstream the gene:11 results
Downstream the gene:16 results
Inside the gene:4 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	73868407	73868700	293	801
CTCF	CD4	SISSRdata	73868407	73868700	293	801
CTCF	Jurkat	GSE12889	73868544	73868812	268	926
CTCF	G2	GSE9613	73868414	73868941	527	925
Nanog	hES	GSE18292	73876761	73877123	362	9190
Rb	Senescent	GSE19898	73867794	73868096	302	193
Sox2	hES	GSE18292	73876780	73877056	276	9166
hScc1	Bcell	GSE12603	73868414	73868897	483	903
hScc1	CdLS	GSE12603	73868414	73869010	596	960
p130	Senescent	GSE19898	73868500	73868668	168	832
p130	shRbQuiescent	GSE19898	73868287	73868746	459	764

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CBP	Jurkat	GSE17954	73850444	73852284	1840	13095
CTCF	G2	GSE9613	73849183	73849942	759	14896
NFkBII	GM10847	GSE19485	73844899	73845928	1029	19045
NFkBII	GM12878	GSE19485	73844381	73845909	1528	19314
NFkBII	GM12878	GSE19485	73863055	73864884	1829	489
NFkBII	GM18526	GSE19485	73844705	73845940	1235	19136
Oct1	Hela	GSE14283	73860700	73860730	30	3744
Rb	Quiescent	GSE19898	73859237	73859670	433	5005
Rb	Senescent	GSE19898	73859062	73859754	692	5051
Rb	shRbSenescence	GSE19898	73859369	73859584	215	4982
TFAP2C	MCF7	GSE21234	73859103	73860046	943	4884
hScc1	Bcell	GSE12603	73849183	73850498	1315	14618
p130	Quiescent	GSE19898	73859178	73859459	281	5140
p130	Senescent	GSE19898	73859050	73859685	635	5091
p130	shRbQuiescent	GSE19898	73859080	73859767	687	5035
p130	shRbSenescent	GSE19898	73859274	73859684	410	4980

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	73867472	73867757	285	0
Rb	Quiescent	GSE19898	73866585	73866800	215	0
hScc1	Bcell	GSE12603	73867472	73867757	285	0
hScc1	CdLS	GSE12603	73866732	73867757	1025	0

Validated miRNA targets

miR Walk:12 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-125b	hsa-mir-125b-1	11	17622355
hsa-miR-125b-1*	hsa-mir-125b-1	11	17622355
hsa-miR-146a	hsa-mir-146a	5	21249428
hsa-miR-146a	hsa-mir-146a	5	17622355
hsa-miR-146a*	hsa-mir-146a	5	21249428
hsa-miR-146a*	hsa-mir-146a	5	17622355
hsa-miR-203	hsa-mir-203	14	20698882
hsa-miR-203	hsa-mir-203	14	18483491
hsa-miR-203	hsa-mir-203	14	17622355
hsa-miR-21	hsa-mir-21	17	17622355
hsa-miR-21*	hsa-mir-21	17	17622355
hsa-miR-483-5p	hsa-mir-483	11	21146586

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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