AutismKB 2.0

Annotation Detail for BRSK2


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Basic Information Top
Gene Symbol:BRSK2 ( C11orf7,FLJ41362,PEN11B,SAD1,STK29 )
Gene Full Name: BR serine/threonine kinase 2
Band: 11p15.5
Quick LinksEntrez ID:9024; OMIM: 609236; Uniprot ID:BRSK2_HUMAN; ENSEMBL ID: ENSG00000174672; HGNC ID: 11405
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
174Phosphothreonine.
178Phosphoserine (By similarity).
294Phosphoserine.
367Phosphoserine.
382Phosphoserine.
389Phosphothreonine.
393Phosphoserine.
412Phosphoserine.
422Phosphothreonine.
423Phosphoserine.
427Phosphoserine.
435Phosphoserine.
466Phosphoserine.
489Phosphoserine.
509Phosphothreonine.
Location(AA) Modifications Resource
174Phosphothreonine.Swiss-Prot 53.0
174Phosphothreonine (LKB1)Phospho.ELM 6.0
178Phosphoserine (By similarity).Swiss-Prot 53.0
422Phosphothreonine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
85Phosphotyrosine(Syk)HMM predict
90Phosphotyrosine(Jak)HMM predict
92Phosphotyrosine(Jak)HMM predict
114Phosphothreonine(MAPK)HMM predict
181Phosphotyrosine(INSR)HMM predict
260Phosphothreonine(PKA)HMM predict
260Phosphothreonine(PKC)HMM predict
324Phosphoserine(CK2)HMM predict
324Phosphoserine(CK1)HMM predict
346Phosphoserine(ATM)HMM predict
412Phosphoserine(CK1)HMM predict
412PhosphoserineHMM predict
414Phosphoserine(IKK)HMM predict
414Phosphoserine(PKB)HMM predict
414Phosphoserine(ATM)HMM predict
418Phosphoserine(IKK)HMM predict
418O-linkedHMM predict
422O-linkedHMM predict
423Phosphoserine(IKK)HMM predict
423Phosphoserine(MAPK)HMM predict
423Phosphoserine(CDC2)HMM predict
423Phosphoserine(ATM)HMM predict
427Phosphoserine(CDK)HMM predict
427O-linkedHMM predict
427Phosphoserine(CDC2)HMM predict
431O-linkedHMM predict
431Phosphothreonine(MAPK)HMM predict
431O-linkedHMM predict
435O-linkedHMM predict
435Phosphoserine(CDC2)HMM predict
439Phosphoserine(CDC2)HMM predict
439O-linkedHMM predict
443O-linkedHMM predict
443Phosphothreonine(MAPK)HMM predict
443PhosphothreonineHMM predict
447Phosphothreonine(CDK)HMM predict
447Phosphothreonine(MAPK)HMM predict
451O-linkedHMM predict
451Phosphothreonine(CDK)HMM predict
451Phosphothreonine(MAPK)HMM predict
455Phosphoserine(CDC2)HMM predict
459Phosphothreonine(MAPK)HMM predict
459O-linkedHMM predict
459Phosphothreonine(CDC2)HMM predict
459O-linkedHMM predict
459Phosphothreonine(CDK)HMM predict
461N-linkedHMM predict
463O-linkedHMM predict
463O-linkedHMM predict
463O-linkedHMM predict
463Phosphothreonine(MAPK)HMM predict
467Phosphoserine(ATM)HMM predict
467O-linkedHMM predict
467Phosphoserine(CDK)HMM predict
469O-linkedHMM predict
489Phosphoserine(CDC2)HMM predict
506Phosphoserine(IKK)HMM predict
507N-linkedHMM predict
509Phosphothreonine(MAPK)HMM predict
559Phosphoserine(CK1)HMM predict
563Phosphoserine(IKK)HMM predict
563Phosphoserine(CK1)HMM predict
608Phosphotyrosine(SRC)HMM predict
664Phosphoserine(CDC2)HMM predict
664Phosphoserine(IKK)HMM predict
691Phosphothreonine(CDC2)HMM predict
691Phosphothreonine(CDK)HMM predict
691Phosphothreonine(MAPK)HMM predict
717SulfotyrosineHMM predict
732ArginineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003957
  • Location:chr11 1367704-1439901
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 1351080 1351925 845 16202
ER Breast-CancerGSE22609 1365640 1366181 541 1794
FOXA1 MCF7GSE15244 1353759 1353882 123 13884
NRSF pAbJurkat 1349100 1350182 1082 18064
NRSF pAbJurkat 1352590 1353825 1235 14497
NRSF pAbJurkat 1360150 1361438 1288 6911
NRSF pAbJurkat 1365244 1366504 1260 1831
P300 T30-glioblastomaGSE21026 1351066 1351973 907 16185
hScc1 BcellGSE12603 1365663 1366033 370 1857
hScc1 BcellGSE12603 1366779 1367425 646 603
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
NRSF pAbJurkat 1439650 1440299 649 73
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER MCF7GSE19013 1416661 1417144 483 0
FOXA1 MCF7GSE15244 1371450 1372977 1527 0
FOXA1 MCF7GSE15244 1407194 1411014 3820 0
FOXA1 MCF7GSE15244 1411658 1412561 903 0
Fos K562GSE19551 1420043 1420348 305 0
FoxA1 MCF7MACSdata 1411901 1412042 141 0
GABP HelaGSE8489 1395279 1396364 1085 0
GABP k562GSE8489 1395279 1396364 1085 0
GATA3 MCF7GSE15244 1407342 1411055 3713 0
H3K27me3 colorectalcancer 1369407 1370112 705 0
NRSF JurkatGSE13047 1378254 1382164 3910 0
NRSF JurkatGSE13047 1400248 1400797 549 0
NRSF JurkatGSE13047 1428486 1429507 1021 0
NRSF JurkatSISSRdata 1413471 1413898 427 0
NRSF mAbJurkat 1371484 1372846 1362 0
NRSF-mono JurkatQuESTdata 1378258 1381359 3101 0
NRSF-mono JurkatQuESTdata 1400205 1400764 559 0
NRSF-mono JurkatQuESTdata 1428332 1429447 1115 0
NRSF pAbJurkat 1370421 1372946 2525 0
NRSF pAbJurkat 1374631 1376289 1658 0
NRSF pAbJurkat 1377978 1379216 1238 0
NRSF pAbJurkat 1383615 1383966 351 0
NRSF pAbJurkat 1386901 1387487 586 0
NRSF pAbJurkat 1390278 1391771 1493 0
NRSF pAbJurkat 1395279 1396364 1085 0
NRSF pAbJurkat 1397752 1398985 1233 0
NRSF pAbJurkat 1401217 1401795 578 0
NRSF pAbJurkat 1404761 1405126 365 0
NRSF pAbJurkat 1407194 1410942 3748 0
NRSF pAbJurkat 1413429 1415022 1593 0
NRSF pAbJurkat 1415627 1416097 470 0
NRSF pAbJurkat 1416858 1418332 1474 0
NRSF pAbJurkat 1419506 1421223 1717 0
NRSF pAbJurkat 1422259 1423101 842 0
NRSF pAbJurkat 1424257 1424715 458 0
NRSF pAbJurkat 1425265 1425973 708 0
NRSF pAbJurkat 1426601 1427268 667 0
NRSF pAbJurkat 1427545 1428296 751 0
NRSF pAbJurkat 1428794 1429061 267 0
NRSF pAbJurkat 1431355 1431666 311 0
NRSF pAbJurkat 1432279 1433098 819 0
NRSF pAbJurkat 1433466 1433971 505 0
NRSF pAbJurkat 1436203 1437157 954 0
NRSF-poly JurkatQuESTdata 1377961 1381692 3731 0
NRSF-poly JurkatQuESTdata 1400194 1400797 603 0
NRSF-poly JurkatQuESTdata 1428475 1430270 1795 0
Oct4 hESGSE17917 1384650 1384914 264 0
RARG MCF7GSE15244 1407268 1410862 3594 0
TAF HelaGSE8489 1395279 1396364 1085 0
TAF HelaGSE8489 1407194 1408019 825 0
TAF k562GSE8489 1395279 1396364 1085 0
TFAP2C MCF7GSE21234 1385415 1385980 565 0
TFAP2C MCF7GSE21234 1414061 1414341 280 0
hScc1 BcellGSE12603 1372494 1373144 650 0
hScc1 BcellGSE12603 1388048 1388571 523 0
hScc1 BcellGSE12603 1389357 1389843 486 0
hScc1 BcellGSE12603 1405890 1406239 349 0
hScc1 BcellGSE12603 1407194 1410942 3748 0
hScc1 BcellGSE12603 1415627 1416028 401 0
hScc1 BcellGSE12603 1416456 1416783 327 0
hScc1 BcellGSE12603 1420691 1421299 608 0
hScc1 BcellGSE12603 1423204 1423532 328 0
hScc1 BcellGSE12603 1427545 1428438 893 0
hScc1 BcellGSE12603 1431139 1431748 609 0
hScc1 BcellGSE12603 1432351 1432671 320 0
hScc1 BcellGSE12603 1436529 1437264 735 0
hScc1 BcellGSE12603 1437941 1439332 1391 0
hScc1 CdLSGSE12603 1376206 1376604 398 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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