AutismKB 2.0

Annotation Detail for DOK2


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Basic Information Top
Gene Symbol:DOK2 ( p56DOK,p56dok-2 )
Gene Full Name: docking protein 2, 56kDa
Band: 8p21.3
Quick LinksEntrez ID:9046; OMIM: 604997; Uniprot ID:DOK2_HUMAN; ENSEMBL ID: ENSG00000147443; HGNC ID: 2991
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
271Phosphotyrosine (By similarity).
299Phosphotyrosine.
345Phosphotyrosine (By similarity).
Location(AA) Modifications Resource
139PhosphotyrosinePhospho.ELM 6.0
271Phosphotyrosine (By similarity).Swiss-Prot 53.0
271PhosphotyrosinePhospho.ELM 6.0
299Phosphotyrosine.Swiss-Prot 53.0
299PhosphotyrosinePhospho.ELM 6.0
345Phosphotyrosine (By similarity).Swiss-Prot 53.0
345PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
77O-linkedHMM predict
139Phosphotyrosine(SRC)HMM predict
139Phosphotyrosine(INSR)HMM predict
219Phosphoserine(IKK)HMM predict
252Phosphothreonine(MAPK)HMM predict
269Phosphoserine(CDC2)HMM predict
271Phosphotyrosine(Jak)HMM predict
282Phosphoserine(CDC2)HMM predict
282O-linkedHMM predict
285Phosphothreonine(CDK)HMM predict
285Phosphothreonine(CDC2)HMM predict
285O-linkedHMM predict
299PhosphotyrosineHMM predict
330Phosphotyrosine(INSR)HMM predict
345SulfotyrosineHMM predict
345PhosphotyrosineHMM predict
345Phosphotyrosine(Syk)HMM predict
345Phosphotyrosine(SRC)HMM predict
345Phosphotyrosine(INSR)HMM predict
357Phosphotyrosine(INSR)HMM predict
359Phosphoserine(CDC2)HMM predict
359Phosphoserine(CDK)HMM predict
359Phosphoserine(ATM)HMM predict
373Phosphothreonine(PKA)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003974
  • Location:chr8 21822330-21827150
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 21828622 21829274 652 1798
FOXA1 MCF7GSE15244 21828881 21829141 260 1861
TFAP2C MCF7GSE21234 21828773 21829218 445 1845
hScc1 BcellGSE12603 21828655 21829274 619 1814
hScc1 CdLSGSE12603 21828655 21829307 652 1831
hScc1 G2GSE9613 21828655 21829307 652 1831
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 21819468 21819753 285 2720
CTCF CD4SISSRdata 21819468 21819753 285 2720
CTCF JurkatGSE12889 21819435 21819821 386 2703
CTCF G2GSE9613 21814694 21815062 368 7453
CTCF G2GSE9613 21816310 21816571 261 5890
CTCF G2GSE9613 21817255 21817801 546 4803
CTCF G2GSE9613 21819070 21820041 971 2775
NRSF JurkatGSE13047 21811607 21812067 460 10494
NRSF-mono JurkatQuESTdata 21811606 21812066 460 10495
NRSF pAbJurkat 21819623 21820041 418 2499
NRSF-poly JurkatQuESTdata 21811522 21812155 633 10492
Sox2 hESGSE18292 21814998 21815423 425 7120
hScc1 BcellGSE12603 21819070 21820004 934 2794
hScc1 CdLSGSE12603 21819070 21820041 971 2775
hScc1 G2GSE9613 21819070 21820041 971 2775
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 21822900 21823406 506 0
CTCF G2GSE9613 21824417 21824748 331 0
NRSF pAbJurkat 21825080 21826385 1305 0
TFAP2C MCF7GSE21234 21822314 21823169 855 0
hScc1 BcellGSE12603 21825532 21825884 352 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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