AutismKB 2.0

Annotation Detail for MAP3K6


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Basic Information Top
Gene Symbol:MAP3K6 ( ASK2,MAPKKK6,MEKK6,MGC125653,MGC20114 )
Gene Full Name: mitogen-activated protein kinase kinase kinase 6
Band: 1p36.11
Quick LinksEntrez ID:9064; OMIM: 604468; Uniprot ID:M3K6_HUMAN; ENSEMBL ID: ENSG00000142733; HGNC ID: 6858
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
804Phosphothreonine.
806Phosphothreonine.
964Phosphoserine.
984Phosphoserine.
1129Phosphoserine.
1149Phosphoserine.
Location(AA) Modifications Resource
533Phosphothreonine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
102Phosphotyrosine(SRC)HMM predict
366SulfotyrosineHMM predict
368SulfotyrosineHMM predict
382Phosphotyrosine(INSR)HMM predict
382Phosphotyrosine(SRC)HMM predict
410Phosphoserine(CK1)HMM predict
410Phosphoserine(ATM)HMM predict
467N-linkedHMM predict
536Phosphotyrosine(INSR)HMM predict
549Phosphotyrosine(INSR)HMM predict
599Phosphoserine(CK1)HMM predict
619Phosphoserine(PKG)HMM predict
635Phosphoserine(PKG)HMM predict
637Phosphoserine(IKK)HMM predict
637O-linkedHMM predict
637Phosphoserine(CDC2)HMM predict
637Phosphoserine(ATM)HMM predict
639Phosphoserine(CK1)HMM predict
640Phosphoserine(CDK)HMM predict
640Phosphoserine(CDC2)HMM predict
640Phosphoserine(CDK)HMM predict
652O-linkedHMM predict
654O-linkedHMM predict
654Phosphoserine(CDK)HMM predict
654Phosphoserine(CDC2)HMM predict
656O-linkedHMM predict
656PhosphothreonineHMM predict
656O-linkedHMM predict
656Phosphothreonine(CDK)HMM predict
656Phosphothreonine(MAPK)HMM predict
658O-linkedHMM predict
660N-linkedHMM predict
661Phosphoserine(CK1)HMM predict
661O-linkedHMM predict
661Phosphoserine(IKK)HMM predict
662O-linkedHMM predict
663O-linkedHMM predict
667O-linkedHMM predict
675O-linkedHMM predict
675Phosphoserine(ATM)HMM predict
680Phosphoserine(CDK)HMM predict
680Phosphoserine(CDC2)HMM predict
680Phosphoserine(MAPK)HMM predict
707PhosphoserineHMM predict
707Phosphoserine(IKK)HMM predict
707Phosphoserine(CK2)HMM predict
707Phosphoserine(MAPK)HMM predict
707Phosphoserine(CDC2)HMM predict
707Phosphoserine(ATM)HMM predict
712Phosphoserine(CK1)HMM predict
772Phosphothreonine(CDK)HMM predict
772Phosphothreonine(CDC2)HMM predict
852Phosphoserine(MAPK)HMM predict
859Phosphoserine(CK1)HMM predict
864Phosphoserine(ATM)HMM predict
867Phosphoserine(CDK)HMM predict
872Phosphoserine(CDK)HMM predict
910Phosphotyrosine(EGFR)HMM predict
910Phosphotyrosine(SRC)HMM predict
963N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004672
  • Location:chr1 27554256-27565923
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Rb QuiescentGSE19898 27565874 27566690 816 359
TFAP2C MCF7GSE21234 27565948 27566355 407 228
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 27556628 27556902 274 0
CTCF CD4GSE12889 27565606 27565756 150 0
CTCF CD4SISSRdata 27556628 27556902 274 0
CTCF CD4SISSRdata 27565606 27565756 150 0
CTCF G2GSE9613 27555093 27557776 2683 0
CTCF G2GSE9613 27559541 27560050 509 0
CTCF G2GSE9613 27562453 27563532 1079 0
CTCF G2GSE9613 27565064 27566233 1169 0
Oct1 H2O2-HelaGSE14283 27564952 27564981 29 0
Oct1 HelaGSE14283 27564953 27564981 28 0
PHF8 293TGSE20725 27564915 27566632 1717 0
Rb GrowingGSE19898 27564652 27564775 123 0
Rb QuiescentGSE19898 27564611 27564862 251 0
Rb SenescentGSE19898 27564596 27564948 352 0
Rb shRbSenescenceGSE19898 27564583 27564841 258 0
hScc1 BcellGSE12603 27556425 27557018 593 0
hScc1 BcellGSE12603 27557976 27558636 660 0
hScc1 BcellGSE12603 27559425 27560050 625 0
hScc1 BcellGSE12603 27562514 27563458 944 0
hScc1 BcellGSE12603 27564809 27565371 562 0
p130 shRbSenescentGSE19898 27564563 27564963 400 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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