AutismKB 2.0

Annotation Detail for PKMYT1


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Basic Information Top
Gene Symbol:PKMYT1 ( DKFZp547K1610,FLJ20093,MYT1 )
Gene Full Name: protein kinase, membrane associated tyrosine/threonine 1
Band: 16p13.3
Quick LinksEntrez ID:9088; OMIM: 602474; Uniprot ID:PMYT1_HUMAN; ENSEMBL ID: ENSG00000127564; HGNC ID: 29650
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
17Phosphothreonine.
40Phosphoserine.
50Phosphoserine.
94Phosphoserine.
120Phosphoserine.
143Phosphoserine.
160Phosphoserine.
398Membrane-association motif.
426Phosphoserine; by PLK1.
469Phosphoserine.
473Phosphoserine.
495Phosphothreonine; by PLK1.
Location(AA) Modifications Resource
94Phosphoserine.Swiss-Prot 53.0
94PhosphoserinePhospho.ELM 6.0
143Phosphoserine.Swiss-Prot 53.0
426Phosphoserine (by PLK1).Swiss-Prot 53.0
426Phosphoserine (PLK1)Phospho.ELM 6.0
495Phosphothreonine (by PLK1).Swiss-Prot 53.0
495Phosphothreonine (PLK1)Phospho.ELM 6.0
Location(AA) Modification Resource
14O-linkedHMM predict
17Phosphothreonine(MAPK)HMM predict
22O-linkedHMM predict
24O-linkedHMM predict
50O-linkedHMM predict
60Phosphoserine(IKK)HMM predict
83Phosphoserine(PKG)HMM predict
83Phosphoserine(PKC)HMM predict
83Phosphoserine(PKB)HMM predict
91Phosphothreonine(PKC)HMM predict
97Phosphotyrosine(Jak)HMM predict
104Phosphoserine(IKK)HMM predict
141Phosphoserine(PKG)HMM predict
169S-palmitoylHMM predict
170S-palmitoylHMM predict
273Phosphotyrosine(INSR)HMM predict
319Phosphotyrosine(Syk)HMM predict
402Phosphoserine(IKK)HMM predict
412PhosphothreonineHMM predict
412Phosphothreonine(MAPK)HMM predict
416O-linkedHMM predict
428Phosphoserine(CK1)HMM predict
441Phosphoserine(MAPK)HMM predict
454O-linkedHMM predict
455Phosphothreonine(CDK)HMM predict
455Phosphothreonine(CDC2)HMM predict
455Phosphothreonine(MAPK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004203
  • Location:chr16 2962794-2970474
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 2973652 2973983 331 3343
CTCF CD4SISSRdata 2973652 2973983 331 3343
CTCF G2GSE9613 2973590 2973782 192 3212
CTCF G2GSE9613 2976006 2976183 177 5620
CTCF G2GSE9613 2977029 2977439 410 6760
CTCF G2GSE9613 2980868 2981226 358 10573
CTCF G2GSE9613 2981713 2981946 233 11355
PHF8 HeLaGSE20725 2969780 2971323 1543 77
PHF8 Hs68minusFBSGSE20725 2970338 2971166 828 278
PHF8 Hs68plusFBSGSE20725 2970174 2971548 1374 387
Rb QuiescentGSE19898 2970600 2970727 127 189
TFAP2C MCF7GSE21234 2970388 2971050 662 245
TFAP2C MCF7GSE21234 2975664 2976765 1101 5740
TFAP2C MCF7GSE21234 2982573 2983216 643 12420
TFAP2C MCF7GSE21234 2985549 2986086 537 15343
hScc1 BcellGSE12603 2973590 2973782 192 3212
hScc1 CdLSGSE12603 2973590 2973782 192 3212
p130 QuiescentGSE19898 2970206 2970968 762 113
p130 SenescentGSE19898 2970178 2970939 761 84
p130 shRbQuiescentGSE19898 2970336 2970844 508 116
p130 shRbSenescentGSE19898 2970661 2970824 163 268
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 2965350 2965594 244 0
CTCF G2GSE9613 2970236 2970668 432 0
LIN9 G0GSE7516 2970264 2970593 329 0
Rb QuiescentGSE19898 2970382 2970543 161 0
Rb SenescentGSE19898 2970242 2970668 426 0
TFAP2C MCF7GSE21234 2967437 2968027 590 0
p130 shRbSenescentGSE19898 2970262 2970616 354 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-27a hsa-mir-27a 19 18006846
hsa-miR-27a hsa-mir-27a 19 18006846
hsa-miR-27a hsa-mir-27a 19 18006846
hsa-miR-27a* hsa-mir-27a 19 18006846
hsa-miR-27a* hsa-mir-27a 19 18006846
hsa-miR-27a* hsa-mir-27a 19 18006846
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
9507 mRNA PAQR4 chr16 2959598 2963484 388 mRNA PKMYT1 chr16 2962794 2970475Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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