AutismKB 2.0

Annotation Detail for USP8


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Basic Information Top
Gene Symbol:USP8 ( FLJ34456,HumORF8,KIAA0055,MGC129718,UBPY )
Gene Full Name: ubiquitin specific peptidase 8
Band: 15q21.2
Quick LinksEntrez ID:9101; OMIM: 603158; Uniprot ID:UBP8_HUMAN; ENSEMBL ID: ENSG00000138592; HGNC ID: 12631
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
413SH3-binding (By similarity).
434Phosphoserine.
452Phosphoserine.
718Phosphoserine.
719Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
220Phosphoserine(CK1)HMM predict
227Phosphoserine(CDK)HMM predict
227O-linkedHMM predict
227Phosphoserine(ATM)HMM predict
318Phosphothreonine(CDK)HMM predict
318Phosphothreonine(MAPK)HMM predict
318O-linkedHMM predict
351O-linkedHMM predict
351Phosphothreonine(MAPK)HMM predict
351Phosphothreonine(CDK)HMM predict
351PhosphothreonineHMM predict
376N-linkedHMM predict
437Phosphoserine(ATM)HMM predict
437Phosphoserine(CDK)HMM predict
530Phosphoserine(CK2)HMM predict
555PhosphoserineHMM predict
557Phosphoserine(IKK)HMM predict
585Phosphothreonine(PKA)HMM predict
623Phosphothreonine(PKA)HMM predict
671Phosphoserine(CDC2)HMM predict
686O-linkedHMM predict
687O-linkedHMM predict
691O-linkedHMM predict
691Phosphoserine(IKK)HMM predict
692Phosphothreonine(MAPK)HMM predict
695O-linkedHMM predict
718Phosphoserine(CK1)HMM predict
718PhosphoserineHMM predict
719Phosphoserine(ATM)HMM predict
719Phosphoserine(CDC2)HMM predict
737O-linkedHMM predict
737Phosphothreonine(MAPK)HMM predict
865Phosphoserine(ATM)HMM predict
869Phosphoserine(IKK)HMM predict
939S-palmitoylHMM predict
1038Phosphoserine(ATM)HMM predict
1094Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005154
  • Location:chr15 48503870-48579256
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
PHF8 293TGSE20725 48503095 48504378 1283 134
PHF8 HeLaGSE20725 48503016 48504474 1458 126
PHF8 Hs68minusFBSGSE20725 48503233 48504472 1239 18
Rb QuiescentGSE19898 48503694 48504021 327 13
Rb SenescentGSE19898 48503445 48504086 641 105
hScc1 BcellGSE12603 48503485 48504238 753 9
p130 QuiescentGSE19898 48503387 48503741 354 307
p130 shRbSenescentGSE19898 48503350 48504259 909 66
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 48503329 48504475 1146 0
H3K4me3 colorectalcancer 48504238 48505037 799 0
H3ac HepG2E 48503865 48504757 892 0
Oct1 H2O2-HelaGSE14283 48534986 48535034 48 0
Oct1 HelaGSE14283 48534987 48535033 46 0
P300 T30-glioblastomaGSE21026 48503380 48504420 1040 0
PHF8 Hs68plusFBSGSE20725 48503268 48504620 1352 0
p130 SenescentGSE19898 48503407 48504342 935 0
p130 shRbQuiescentGSE19898 48503378 48504468 1090 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
8811 mRNA USP8 chr15 48503870 48579263 424 mRNA chr15 48571794 48574320Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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