AutismKB 2.0

Annotation Detail for EXO1


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Basic Information Top
Gene Symbol:EXO1 ( HEX1,hExoI )
Gene Full Name: exonuclease 1
Band: 1q43
Quick LinksEntrez ID:9156; OMIM: 606063; Uniprot ID:EXO1_HUMAN; ENSEMBL ID: ENSG00000174371; HGNC ID: 3511
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
376Phosphoserine.
422Phosphoserine.
454Phosphoserine.
482N6-acetyllysine.
581Phosphothreonine.
598Phosphoserine.
621Phosphothreonine.
623Phosphoserine.
639Phosphoserine.
660Phosphoserine.
674Phosphoserine.
700Phosphoserine.
702Phosphoserine.
714Phosphoserine; by ATR.
746Phosphoserine.
Location(AA) Modifications Resource
598Phosphoserine.Swiss-Prot 53.0
598PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
113Phosphoserine(PKG)HMM predict
139Phosphoserine(ATM)HMM predict
226Phosphotyrosine(Jak)HMM predict
264N-linkedHMM predict
279N-linkedHMM predict
280N-linkedHMM predict
341SulfotyrosineHMM predict
355Phosphoserine(IKK)HMM predict
355Phosphoserine(CAMK2)HMM predict
366N-linkedHMM predict
374N-linkedHMM predict
393N-linkedHMM predict
415Phosphoserine(PKG)HMM predict
432Phosphoserine(ATM)HMM predict
432Phosphoserine(CK1)HMM predict
475Phosphothreonine(CDC2)HMM predict
475Phosphothreonine(CDK)HMM predict
475Phosphothreonine(MAPK)HMM predict
521Phosphoserine(PKG)HMM predict
542Phosphotyrosine(EGFR)HMM predict
542Phosphotyrosine(SRC)HMM predict
558N-linkedHMM predict
587Phosphoserine(IKK)HMM predict
587Phosphoserine(CK1)HMM predict
598Phosphoserine(CAMK2)HMM predict
621Phosphothreonine(MAPK)HMM predict
621O-linkedHMM predict
623Phosphoserine(ATM)HMM predict
623Phosphoserine(CDC2)HMM predict
623Phosphoserine(PKB)HMM predict
623Phosphoserine(IKK)HMM predict
625Phosphoserine(CDC2)HMM predict
625O-linkedHMM predict
627O-linkedHMM predict
637Phosphoserine(PKG)HMM predict
639Phosphoserine(IKK)HMM predict
639Phosphoserine(CDK)HMM predict
639Phosphoserine(CDC2)HMM predict
642Phosphoserine(IKK)HMM predict
647N-linkedHMM predict
649Phosphoserine(CK1)HMM predict
652Phosphoserine(IKK)HMM predict
652Phosphoserine(ATM)HMM predict
656Phosphoserine(IKK)HMM predict
659Phosphoserine(CK2)HMM predict
660Phosphoserine(ATM)HMM predict
660Phosphoserine(CK1)HMM predict
674Phosphoserine(ATM)HMM predict
674Phosphoserine(IKK)HMM predict
674Phosphoserine(CK1)HMM predict
676Phosphoserine(ATM)HMM predict
679PhosphoserineHMM predict
688N-linkedHMM predict
690Phosphoserine(CK1)HMM predict
693Phosphoserine(IKK)HMM predict
697Phosphoserine(IKK)HMM predict
697Phosphoserine(CK1)HMM predict
700Phosphoserine(CK2)HMM predict
702Phosphoserine(CK1)HMM predict
702PhosphoserineHMM predict
702Phosphoserine(IKK)HMM predict
702Phosphoserine(CK2)HMM predict
705Phosphoserine(CK2)HMM predict
714Phosphoserine(ATM)HMM predict
732Phosphothreonine(CDK)HMM predict
732Phosphothreonine(MAPK)HMM predict
732Phosphothreonine(CDC2)HMM predict
749Phosphoserine(CK1)HMM predict
749O-linkedHMM predict
749Phosphoserine(IKK)HMM predict
751Phosphoserine(CK1)HMM predict
752Phosphothreonine(PKC)HMM predict
815Phosphoserine(CDC2)HMM predict
815PhosphoserineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_003686
  • Location:chr1 240078157-240119669
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 240067059 240068755 1696 10251
CTCF CD4GSE12889 240077644 240077918 274 377
CTCF CD4SISSRdata 240077644 240077918 274 377
CTCF G2GSE9613 240077726 240078032 306 279
ETS1 JurkatGSE17954 240077348 240078745 1397 111
H3ac HepG2E 240061841 240062137 296 16169
LIN54 G0GSE7516 240077726 240078451 725 69
Oct4 hESGSE17917 240077698 240077971 273 323
P300 T30-glioblastomaGSE21026 240067286 240068681 1395 10174
Rb QuiescentGSE19898 240077660 240078425 765 115
Rb SenescentGSE19898 240077640 240077980 340 348
Rb shRbSenescenceGSE19898 240077892 240078316 424 54
STAT1 HeLaGSE12782 240066751 240070618 3867 9473
STAT1 HeLaGSE12783 240064354 240065488 1134 13237
STAT1 HeLaGSE12783 240066099 240068723 2624 10747
STAT1 IFNSISSRdata 240066715 240068441 1726 10580
Sox2 hESGSE18292 240064771 240065134 363 13205
TAF k562GSE8489 240061841 240062175 334 16150
TAF k562GSE8489 240076818 240077726 908 886
hScc1 BcellGSE12603 240077726 240077926 200 332
p130 shRbSenescentGSE19898 240077444 240078851 1407 10
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
hScc1 BcellGSE12603 240126393 240126638 245 6846
hScc1 CdLSGSE12603 240126393 240126896 503 6975
hScc1 G2GSE9613 240126393 240126677 284 6866
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
E2F4 G0GSE7516 240077726 240078960 1234 0
E2F4 SGSE7516 240077507 240079133 1626 0
H3ac HepG2E 240078213 240079543 1330 0
LIN9 G0GSE7516 240077471 240079399 1928 0
LIN9 SGSE7516 240077435 240079399 1964 0
PAX3-FKHR Rh4GSE19063 240100039 240101409 1370 0
Rb GrowingGSE19898 240078030 240078392 362 0
Rb SenescentGSE19898 240078002 240078473 471 0
TAF k562GSE8489 240078257 240079840 1583 0
p130 QuiescentGSE19898 240077707 240078660 953 0
p130 SenescentGSE19898 240077597 240078919 1322 0
p130 shRbQuiescentGSE19898 240077653 240078853 1200 0
p130 G0GSE7516 240077471 240079030 1559 0
p130 SGSE7516 240077471 240079249 1778 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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