AutismKB 2.0

Annotation Detail for MYLK3


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Basic Information Top
Gene Symbol:MYLK3 ( MGC126319,MGC126320,MLCK,MLCK2,caMLCK )
Gene Full Name: myosin light chain kinase 3
Band: 16q11.2
Quick LinksEntrez ID:91807; OMIM: 612147; Uniprot ID:MYLK3_HUMAN; ENSEMBL ID: ENSG00000140795; HGNC ID: 29826
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
No data
Location(AA) Modification Resource
152Phosphoserine(CDC2)HMM predict
156Phosphoserine(CDC2)HMM predict
156Phosphoserine(ATM)HMM predict
253Phosphothreonine(MAPK)HMM predict
253Phosphothreonine(CDK)HMM predict
290O-linkedHMM predict
291O-linkedHMM predict
305Phosphothreonine(MAPK)HMM predict
327O-linkedHMM predict
327Phosphoserine(IKK)HMM predict
331Phosphothreonine(CDC2)HMM predict
331Phosphothreonine(MAPK)HMM predict
361O-linkedHMM predict
378Phosphothreonine(PKC)HMM predict
393Phosphothreonine(CDC2)HMM predict
393Phosphothreonine(MAPK)HMM predict
407Phosphoserine(CK1)HMM predict
408O-linkedHMM predict
408Phosphoserine(CDC2)HMM predict
408Phosphoserine(CDK)HMM predict
429Phosphoserine(PKA)HMM predict
433Phosphoserine(CK2)HMM predict
450Phosphoserine(CDC2)HMM predict
490Phosphoserine(CDC2)HMM predict
584Phosphoserine(IKK)HMM predict
646N-linkedHMM predict
663Phosphotyrosine(Jak)HMM predict
740Phosphoserine(CK2)HMM predict
760Phosphoserine(PKA)HMM predict
782Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_182493
  • Location:chr16 45298948-45339721
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 45349460 45349654 194 9836
FOXA1 MCF7GSE15244 45348282 45349387 1105 9113
Nanog hESGSE18292 45339870 45340026 156 227
Oct1 HelaGSE14283 45341568 45341603 35 1864
P300 T30-glioblastomaGSE21026 45348570 45349404 834 9266
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
p63 keratinocytesGSE17611 45296144 45296787 643 2483
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 45329172 45329600 428 0
Oct1 HelaGSE14283 45335410 45335439 29 0
Oct1 HelaGSE14283 45336602 45336647 45 0
TFAP2C MCF7GSE21234 45334322 45334878 556 0
hScc1 BcellGSE12603 45321026 45321607 581 0
hScc1 BcellGSE12603 45326948 45327123 175 0
hScc1 BcellGSE12603 45334671 45335087 416 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018