Annotation Detail for PTPLA

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Basic Information Top

Gene Symbol:	PTPLA ( CAP,HACD1 )
Gene Full Name:	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
Band:	10p14-p13
Quick Links	Entrez ID:9200; OMIM: 610467; Uniprot ID:HACD1_HUMAN; ENSEMBL ID: ENSG00000165996; HGNC ID:
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:4 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:0 results

Location(AA)	Modification
22	Phosphoserine.
30	Phosphoserine.
32	Phosphothreonine.
243	N-linked (GlcNAc...) (Potential).

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_014241
Location:chr10 17671965-17699378
strand:-

Upstream the gene:4 results
Downstream the gene:1 results
Inside the gene:12 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	17699456	17699611	155	155
CTCF	CD4	SISSRdata	17699456	17699611	155	155
Rb	shRbSenescence	GSE19898	17699665	17699865	200	387
p130	Senescent	GSE19898	17704253	17704415	162	4956

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Oct1	H2O2-Hela	GSE14283	17666523	17666560	37	5424

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	17689548	17689928	380	0
CTCF	CD4	SISSRdata	17689548	17689928	380	0
Myc	K562	GSE19551	17698373	17698809	436	0
Oct1	Hela	GSE14283	17676695	17676738	43	0
Oct1	Hela	GSE14283	17682232	17682261	29	0
Oct1	Hela	GSE14283	17694962	17695003	41	0
PHF8	HeLa	GSE20725	17698691	17699826	1135	0
hScc1	Bcell	GSE12603	17689421	17689950	529	0
hScc1	Bcell	GSE12603	17698943	17699376	433	0
hScc1	CdLS	GSE12603	17681065	17681490	425	0
hScc1	CdLS	GSE12603	17689307	17689989	682	0
hScc1	CdLS	GSE12603	17699058	17699527	469	0

Validated miRNA targets

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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