AutismKB 2.0

Annotation Detail for CD22


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Basic Information Top
Gene Symbol:CD22 ( FLJ22814,MGC130020,SIGLEC-2,SIGLEC2 )
Gene Full Name: CD22 molecule
Band: 19q13.12
Quick LinksEntrez ID:933; OMIM: 107266; Uniprot ID:CD22_HUMAN; ENSEMBL ID: ENSG00000012124; HGNC ID: 1643
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
67N-linked (GlcNAc...) (Potential).
101N-linked (GlcNAc...) (Potential).
112N-linked (GlcNAc...) (Potential).
135N-linked (GlcNAc...) (Potential).
164N-linked (GlcNAc...) (Potential).
231N-linked (GlcNAc...) (Potential).
363N-linked (GlcNAc...) (Potential).
445N-linked (GlcNAc...) (Potential).
448N-linked (GlcNAc...) (Potential).
479N-linked (GlcNAc...) (Potential).
574N-linked (GlcNAc...) (Potential).
634N-linked (GlcNAc...) (Potential).
762Phosphotyrosine (By similarity).
765ITIM motif 1.
799ITIM motif 2.
807Phosphotyrosine (By similarity).
822Phosphotyrosine (By similarity).
825ITIM motif 3.
842Phosphotyrosine (By similarity).
845ITIM motif 4.
Location(AA) Modifications Resource
67N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
101N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
112N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
135N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
164N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
231N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
363N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
445N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
448N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
479N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
574N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
634N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
762Phosphotyrosine (By similarity).Swiss-Prot 53.0
807Phosphotyrosine (By similarity).Swiss-Prot 53.0
807PhosphotyrosinePhospho.ELM 6.0
822Phosphotyrosine (By similarity).Swiss-Prot 53.0
842Phosphotyrosine (By similarity).Swiss-Prot 53.0
842PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
67N-linkedHMM predict
101N-linkedHMM predict
112N-linkedHMM predict
135N-linkedHMM predict
154Phosphoserine(ATM)HMM predict
161S-palmitoylHMM predict
164N-linkedHMM predict
191O-linkedHMM predict
192O-linkedHMM predict
194O-linkedHMM predict
207Phosphoserine(ATM)HMM predict
207Phosphoserine(CDC2)HMM predict
231N-linkedHMM predict
237N-linkedHMM predict
274Phosphotyrosine(Jak)HMM predict
274Phosphotyrosine(INSR)HMM predict
276Phosphothreonine(PKC)HMM predict
341Phosphoserine(MAPK)HMM predict
347Phosphoserine(ATM)HMM predict
363N-linkedHMM predict
369N-linkedHMM predict
423Phosphothreonine(PKA)HMM predict
445N-linkedHMM predict
448N-linkedHMM predict
450Phosphoserine(CK1)HMM predict
479N-linkedHMM predict
489Phosphoserine(IKK)HMM predict
492O-linkedHMM predict
554Phosphoserine(PKG)HMM predict
599Phosphoserine(PKG)HMM predict
601Phosphoserine(IKK)HMM predict
634N-linkedHMM predict
670Phosphoserine(CDC2)HMM predict
717Phosphoserine(CAMK2)HMM predict
724N-linkedHMM predict
726Phosphoserine(ATM)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001771
  • Location:chr19 40511951-40530101
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF HelaGSE12889 40510526 40510715 189 1331
Myc K562GSE19551 40510316 40510765 449 1411
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
hScc1 BcellGSE12603 40530423 40531036 613 628
hScc1 CdLSGSE12603 40530423 40530847 424 534
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 40525251 40525514 263 0
ER MCF7GSE19013 40516589 40517167 578 0
ER MCF7GSE19013 40518646 40519245 599 0
NFkBII GM10847GSE19485 40528433 40531234 2801 0
NFkBII GM12878GSE19485 40528666 40531198 2532 0
NFkBII GM12892GSE19485 40517597 40518547 950 0
NFkBII GM12892GSE19485 40528300 40531222 2922 0
Pol2 GM12878GSE19551 40511552 40512798 1246 0
hScc1 BcellGSE12603 40512281 40512626 345 0
hScc1 BcellGSE12603 40525251 40525477 226 0
hScc1 BcellGSE12603 40529361 40529735 374 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018