Annotation Detail for SLC9A3R2

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Basic Information Top

Gene Symbol:	SLC9A3R2 ( E3KARP,MGC104639,NHE3RF2,NHERF-2,NHERF2,OCTS2,SIP-1,SIP1,TKA-1 )
Gene Full Name:	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
Band:	16p13.3
Quick Links	Entrez ID:9351; OMIM: 606553; Uniprot ID:NHRF2_HUMAN; ENSEMBL ID: ENSG00000065054; HGNC ID: 11076
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

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PTM Sites from Uniprot:4 results
Experimental PTM Sites from dbPTM:3 results
Predicted PTM Sites by profile HMM from dbPTM:10 results

Location(AA)	Modification
183	Phosphoserine.
254	Phosphoserine.
272	Phosphoserine (By similarity).
275	Phosphoserine.

Location(AA)	Modifications	Resource
272	Phosphoserine (By similarity).	Swiss-Prot 53.0
275	Phosphoserine.	Swiss-Prot 53.0
275	Phosphoserine	Phospho.ELM 6.0

Location(AA)	Modification	Resource
29	O-linked	HMM predict
43	Phosphoserine(CDC2)	HMM predict
92	Phosphothreonine(CK2)	HMM predict
242	Phosphothreonine(MAPK)	HMM predict
254	Phosphoserine(CDC2)	HMM predict
254	O-linked	HMM predict
257	O-linked	HMM predict
258	N-linked	HMM predict
280	Phosphoserine(CK2)	HMM predict
284	Phosphothreonine(CK2)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_004785
Location:chr16 2016929-2028483
strand:+

Upstream the gene:16 results
Downstream the gene:0 results
Inside the gene:14 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	2013178	2013388	210	3647
CTCF	CD4	SISSRdata	2013178	2013388	210	3647
CTCF	Hela	GSE12889	2013173	2013342	169	3672
CTCF	Jurkat	GSE12889	2013137	2013377	240	3673
CTCF	G2	GSE9613	2009704	2010275	571	6940
CTCF	G2	GSE9613	2012586	2013732	1146	3771
CTCF	G2	GSE9613	2016584	2016748	164	264
ER	MCF7	GSE19013	2012524	2013064	540	4136
Rb	Growing	GSE19898	2013184	2013466	282	3605
Rb	Senescent	GSE19898	2012964	2013379	415	3758
Rb	shRbSenescence	GSE19898	2013215	2013415	200	3615
TFAP2C	MCF7	GSE21234	2012577	2013855	1278	3714
hScc1	Bcell	GSE12603	2012725	2013685	960	3725
hScc1	CdLS	GSE12603	2013006	2013771	765	3541
p130	Senescent	GSE19898	2012672	2013309	637	3939
p130	shRbSenescent	GSE19898	2013104	2013420	316	3668

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	2017055	2017750	695
CTCF	G2	GSE9613	2019440	2020332	892
CTCF	G2	GSE9613	2023910	2024527	617
CTCF	G2	GSE9613	2025072	2026431	1359
CTCF	G2	GSE9613	2026831	2027991	1160
NRSF	pAb	Jurkat	2020332	2020600	268
Rb	shRbSenescence	GSE19898	2023624	2023897	273
Rb	shRbSenescence	GSE19898	2027161	2027365	204
TFAP2C	MCF7	GSE21234	2025638	2026301	663
hScc1	Bcell	GSE12603	2025362	2025741	379
p130	Quiescent	GSE19898	2023597	2023806	209
p130	Senescent	GSE19898	2025652	2026220	568
p130	shRbQuiescent	GSE19898	2025831	2026391	560
p130	shRbSenescent	GSE19898	2025719	2026063	344

Validated miRNA targets

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miR Walk:88 results
Tarbase V5.0:2 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-141	hsa-mir-141	12	19830559
hsa-miR-141	hsa-mir-141	12	18376396
hsa-miR-141	hsa-mir-141	12	18411277
hsa-miR-141	hsa-mir-141	12	19830559
hsa-miR-141	hsa-mir-141	12	18376396
hsa-miR-141	hsa-mir-141	12	18411277
hsa-miR-141*	hsa-mir-141	12	19830559
hsa-miR-141*	hsa-mir-141	12	18376396
hsa-miR-141*	hsa-mir-141	12	18411277
hsa-miR-141*	hsa-mir-141	12	19830559
hsa-miR-141*	hsa-mir-141	12	18376396
hsa-miR-141*	hsa-mir-141	12	18411277
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-192	hsa-mir-192	11	17360662
hsa-miR-192	hsa-mir-192	11	17360662
hsa-miR-192*	hsa-mir-192	11	17360662
hsa-miR-192*	hsa-mir-192	11	17360662
hsa-miR-200a	hsa-mir-200a	1	18376396
hsa-miR-200a	hsa-mir-200a	1	18411277
hsa-miR-200a	hsa-mir-200a	1	18376396
hsa-miR-200a	hsa-mir-200a	1	18411277
hsa-miR-200a*	hsa-mir-200a	1	18376396
hsa-miR-200a*	hsa-mir-200a	1	18411277
hsa-miR-200a*	hsa-mir-200a	1	18376396
hsa-miR-200a*	hsa-mir-200a	1	18411277
hsa-miR-200b	hsa-mir-200b	1	18376396
hsa-miR-200b	hsa-mir-200b	1	18411277
hsa-miR-200b	hsa-mir-200b	1	18376396
hsa-miR-200b	hsa-mir-200b	1	18411277
hsa-miR-200b*	hsa-mir-200b	1	18376396
hsa-miR-200b*	hsa-mir-200b	1	18411277
hsa-miR-200b*	hsa-mir-200b	1	18376396
hsa-miR-200b*	hsa-mir-200b	1	18411277
hsa-miR-200c	hsa-mir-200c	12	18376396
hsa-miR-200c	hsa-mir-200c	12	18411277
hsa-miR-200c	hsa-mir-200c	12	18376396
hsa-miR-200c	hsa-mir-200c	12	18411277
hsa-miR-200c*	hsa-mir-200c	12	18376396
hsa-miR-200c*	hsa-mir-200c	12	18411277
hsa-miR-200c*	hsa-mir-200c	12	18376396
hsa-miR-200c*	hsa-mir-200c	12	18411277
hsa-miR-205	hsa-mir-205	1	18376396
hsa-miR-205	hsa-mir-205	1	18376396
hsa-miR-215	hsa-mir-215	1	17360662
hsa-miR-215	hsa-mir-215	1	17360662
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040
hsa-miR-429	hsa-mir-429	1	18376396
hsa-miR-429	hsa-mir-429	1	18411277
hsa-miR-429	hsa-mir-429	1	18376396
hsa-miR-429	hsa-mir-429	1	18411277

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
1282	Unknown	pSILAC	miR-30	SLC9A3R2	down 50-25%	18668040
1283	Unknown	pSILAC	miR-30	SLC9A3R2	down 50-25%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000065054		n_a	n_a	n_a	"lymphocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, sarcoma"
ENSG00000065054		n_a	n_a	n_a	"lymphocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, sarcoma"

Cis-Nats regulation

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Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for SLC9A3R2

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics