AutismKB 2.0

Annotation Detail for SLIT2


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Basic Information Top
Gene Symbol:SLIT2 ( FLJ14420,SLIL3,Slit-2 )
Gene Full Name: slit homolog 2 (Drosophila)
Band: 4p15.31
Quick LinksEntrez ID:9353; OMIM: 603746; Uniprot ID:SLIT2_HUMAN; ENSEMBL ID: ENSG00000145147; HGNC ID: 11086
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
66N-linked (GlcNAc...) (Potential).
186N-linked (GlcNAc...) (Potential).
564N-linked (GlcNAc...) (Potential).
623N-linked (GlcNAc...).
794N-linked (GlcNAc...) (Potential).
799N-linked (GlcNAc...) (Potential).
1009N-linked (GlcNAc...) (Potential).
1010N-linked (GlcNAc...) (Potential).
1019N-linked (GlcNAc...) (Potential).
1183N-linked (GlcNAc...) (Potential).
1266N-linked (GlcNAc...) (Potential).
1300N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
66N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
186N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
564N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
623N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
794N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
799N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1009N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1010N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1019N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1183N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1266N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1300N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
33O-linkedHMM predict
66N-linkedHMM predict
93Phosphothreonine(PKC)HMM predict
186N-linkedHMM predict
191Phosphoserine(PKG)HMM predict
321Phosphoserine(CDC2)HMM predict
410Phosphothreonine(PKC)HMM predict
417Phosphoserine(CDC2)HMM predict
459Phosphoserine(CDC2)HMM predict
564N-linkedHMM predict
567N-linkedHMM predict
568N-linkedHMM predict
623N-linkedHMM predict
799N-linkedHMM predict
862Phosphotyrosine(Jak)HMM predict
878Phosphotyrosine(Syk)HMM predict
922S-palmitoylHMM predict
1009N-linkedHMM predict
1010N-linkedHMM predict
1019N-linkedHMM predict
1170Phosphotyrosine(EGFR)HMM predict
1218Phosphoserine(PKG)HMM predict
1251Phosphoserine(IKK)HMM predict
1255Phosphoserine(CK1)HMM predict
1255Phosphoserine(ATM)HMM predict
1266N-linkedHMM predict
1300N-linkedHMM predict
1333S-palmitoylHMM predict
1461SulfotyrosineHMM predict
1462Phosphotyrosine(Jak)HMM predict
1468Phosphotyrosine(Jak)HMM predict
1473Phosphothreonine(PKC)HMM predict
1492S-palmitoylHMM predict
1525ThreonineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004787
  • Location:chr4 19864332-20229885
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 19858883 19859421 538 5181
CTCF G2GSE9613 19862335 19864079 1744 1126
ER E2-MCF7GSE14664 19853768 19853803 35 10547
hScc1 BcellGSE12603 19858883 19859114 231 5334
hScc1 BcellGSE12603 19862303 19863239 936 1562
hScc1 G2GSE9613 19858883 19859348 465 5217
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 20005995 20006174 179 0
CTCF CD4GSE12889 20029646 20029915 269 0
CTCF CD4GSE12889 20155510 20155720 210 0
CTCF CD4SISSRdata 20005995 20006174 179 0
CTCF CD4SISSRdata 20029646 20029915 269 0
CTCF CD4SISSRdata 20155510 20155720 210 0
CTCF G2GSE9613 19864444 19864831 387 0
CTCF G2GSE9613 19865114 19865538 424 0
CTCF G2GSE9613 19896003 19896246 243 0
CTCF G2GSE9613 19916656 19916982 326 0
CTCF G2GSE9613 19934896 19935245 349 0
CTCF G2GSE9613 20005757 20006306 549 0
CTCF G2GSE9613 20033306 20033489 183 0
CTCF G2GSE9613 20227670 20227816 146 0
FOXA1 MCF7GSE15244 20104295 20105190 895 0
FOXA1 eGFPGSE10845 20104295 20105190 895 0
FoxA1 MCF7MACSdata 20104526 20104910 384 0
FoxA1 MCF7MACSdata 20123191 20123570 379 0
H3K27me3 colorectalcancer 19866049 19866366 317 0
NRSF JurkatGSE13047 20084692 20085510 818 0
NRSF mAbJurkat 20080821 20081175 354 0
NRSF mAbJurkat 20084861 20086919 2058 0
NRSF-mono JurkatQuESTdata 20084691 20085509 818 0
NRSF-poly JurkatQuESTdata 20084802 20085281 479 0
Nanog ESGSE20650 20183643 20184163 520 0
Nanog hESGSE18292 19893657 19894454 797 0
Nanog hESGSE18292 20200143 20200346 203 0
Oct1 H2O2-HelaGSE14283 19975185 19975226 41 0
Oct1 H2O2-HelaGSE14283 20017613 20017640 27 0
Oct1 H2O2-HelaGSE14283 20043875 20043907 32 0
Oct1 H2O2-HelaGSE14283 20092393 20092422 29 0
Oct1 H2O2-HelaGSE14283 20170789 20170830 41 0
Oct1 H2O2-HelaGSE14283 20213217 20213245 28 0
Oct1 HelaGSE14283 19865633 19865681 48 0
Oct1 HelaGSE14283 19942231 19942261 30 0
Oct1 HelaGSE14283 19975186 19975226 40 0
Oct1 HelaGSE14283 20043863 20043910 47 0
Oct1 HelaGSE14283 20092391 20092422 31 0
Oct1 HelaGSE14283 20170789 20170830 41 0
P300 T0-glioblastomaGSE21026 19922555 19923207 652 0
P300 T0-glioblastomaGSE21026 20214496 20215206 710 0
RARA MCF7GSE15244 20104188 20105190 1002 0
STAT1 IFNSISSRdata 20029509 20029949 440 0
Sox2 hESGSE18292 19893653 19894226 573 0
p130 shRbQuiescentGSE19898 20228357 20228871 514 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-218 hsa-mir-218-1 4 20838434
hsa-miR-218 hsa-mir-218-2 5 20838434
hsa-miR-218 hsa-mir-218-1 4 21385904
hsa-miR-218 hsa-mir-218-2 5 21385904
hsa-miR-218 hsa-mir-218-1 4 21385766
hsa-miR-218 hsa-mir-218-2 5 21385766
hsa-miR-218-1* hsa-mir-218-1 4 20838434
hsa-miR-218-2* hsa-mir-218-2 5 20838434
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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