AutismKB 2.0

Annotation Detail for NRXN3


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Basic Information Top
Gene Symbol:NRXN3 ( C14orf60,KIAA0743,MGC176711 )
Gene Full Name: neurexin 3
Band: 14q24.3-q31.1
Quick LinksEntrez ID:9369; OMIM: 600567; Uniprot ID:NRX3A_HUMAN; ENSEMBL ID: ENSG00000021645; HGNC ID: 8010
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
58N-linked (GlcNAc...) (Potential).
105N-linked (GlcNAc...) (Potential).
757N-linked (GlcNAc...) (Potential).
1189N-linked (GlcNAc...) (Potential).
1257N-linked (GlcNAc...) (Potential).
1301N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
10Phosphoserine.Swiss-Prot 53.0
58N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
105N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
184N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
252N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
296N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
757N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1189N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1257N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1301N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
28S-palmitoylHMM predict
37O-linkedHMM predict
43O-linkedHMM predict
45O-linkedHMM predict
47Phosphoserine(CK1)HMM predict
48Phosphoserine(ATM)HMM predict
48Phosphoserine(CDC2)HMM predict
51O-linkedHMM predict
53Phosphoserine(ATM)HMM predict
66Phosphoserine(PKA)HMM predict
74Phosphoserine(CDC2)HMM predict
79MethylarginineHMM predict
105N-linkedHMM predict
108Phosphothreonine(PKC)HMM predict
140Phosphotyrosine(Syk)HMM predict
160Phosphoserine(CK2)HMM predict
184N-linkedHMM predict
239Phosphoserine(ATM)HMM predict
252N-linkedHMM predict
272Phosphoserine(ATM)HMM predict
279Phosphoserine(CK2)HMM predict
287O-linkedHMM predict
296N-linkedHMM predict
305Phosphotyrosine(INSR)HMM predict
316Phosphoserine(CK2)HMM predict
317Phosphoserine(CK1)HMM predict
317Phosphoserine(CK2)HMM predict
317PhosphoserineHMM predict
351O-linkedHMM predict
355O-linkedHMM predict
355O-linkedHMM predict
367SulfotyrosineHMM predict
372SulfotyrosineHMM predict
377Phosphoserine(CK2)HMM predict
386Phosphoserine(CDC2)HMM predict
395PhosphoserineHMM predict
395Phosphoserine(CDC2)HMM predict
424Phosphotyrosine(EGFR)HMM predict
424Phosphotyrosine(Jak)HMM predict
424Phosphotyrosine(Syk)HMM predict
431O-linkedHMM predict
465O-linkedHMM predict
465O-linkedHMM predict
467O-linkedHMM predict
468O-linkedHMM predict
469O-linkedHMM predict
470O-linkedHMM predict
471O-linkedHMM predict
540N-linkedHMM predict
561Phosphoserine(IKK)HMM predict
568Phosphoserine(CK2)HMM predict
603Phosphotyrosine(INSR)HMM predict
611N-linkedHMM predict
630LysineHMM predict
638Phosphoserine(PKA)HMM predict
643Phosphoserine(PKA)HMM predict
684Phosphoserine(PKG)HMM predict
693Phosphotyrosine(INSR)HMM predict
730O-linkedHMM predict
757N-linkedHMM predict
819Phosphothreonine(PKC)HMM predict
890Phosphotyrosine(INSR)HMM predict
964Phosphoserine(IKK)HMM predict
1113Phosphothreonine(PKC)HMM predict
1165Phosphoserine(CK2)HMM predict
1189N-linkedHMM predict
1257N-linkedHMM predict
1292O-linkedHMM predict
1301N-linkedHMM predict
1321Phosphoserine(CK2)HMM predict
1322PhosphoserineHMM predict
1322Phosphoserine(CK2)HMM predict
1322Phosphoserine(CK1)HMM predict
1356O-linkedHMM predict
1360O-linkedHMM predict
1360O-linkedHMM predict
1382Phosphoserine(CK2)HMM predict
1429Phosphotyrosine(Syk)HMM predict
1429Phosphotyrosine(EGFR)HMM predict
1429Phosphotyrosine(Jak)HMM predict
1436O-linkedHMM predict
1470O-linkedHMM predict
1470O-linkedHMM predict
1472O-linkedHMM predict
1473O-linkedHMM predict
1474O-linkedHMM predict
1475O-linkedHMM predict
1476O-linkedHMM predict
1545N-linkedHMM predict
1566Phosphoserine(IKK)HMM predict
1608Phosphotyrosine(INSR)HMM predict
1616N-linkedHMM predict
1635LysineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004796
  • Location:chr14 77939845-79400510
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
NRSF JurkatGSE13047 77935413 77936227 814 4026
NRSF mAbJurkat 77935495 77936941 1446 3628
NRSF-mono JurkatQuESTdata 77935413 77936377 964 3951
NRSF-poly JurkatQuESTdata 77935378 77936083 705 4115
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 78585120 78585597 477 0
CBP T30-glioblastomaGSE21026 78584809 78585311 502 0
CTCF CD4GSE12889 78102715 78102982 267 0
CTCF CD4GSE12889 78384444 78384614 170 0
CTCF CD4GSE12889 78495842 78496086 244 0
CTCF CD4SISSRdata 78102715 78102982 267 0
CTCF CD4SISSRdata 78384444 78384614 170 0
CTCF CD4SISSRdata 78495842 78496086 244 0
CTCF HelaGSE12889 78102758 78102998 240 0
CTCF JurkatGSE12889 78102742 78102978 236 0
CTCF JurkatGSE12889 78495758 78496173 415 0
CTCF G2GSE9613 77984521 77984891 370 0
CTCF G2GSE9613 78102634 78102944 310 0
CTCF G2GSE9613 78133996 78134542 546 0
CTCF G2GSE9613 78294393 78294621 228 0
CTCF G2GSE9613 78372925 78373266 341 0
CTCF G2GSE9613 78384303 78384585 282 0
CTCF G2GSE9613 78438166 78438313 147 0
CTCF G2GSE9613 78470061 78470424 363 0
CTCF G2GSE9613 78495684 78496003 319 0
CTCF G2GSE9613 78505246 78505573 327 0
ER E2-MCF7GSE14664 78115738 78115777 39 0
ER E2-MCF7GSE14664 78340087 78340169 82 0
ER Fulvestrant-MCF7GSE14664 78186618 78186664 46 0
ER Fulvestrant-MCF7GSE14664 78523178 78523223 45 0
ER Fulvestrant-MCF7GSE14664 78671436 78671488 52 0
ETS1 JurkatGSE17954 77984250 77985120 870 0
Fos K562GSE19551 78226981 78227307 326 0
Myc hESGSE17917 78815249 78815529 280 0
NRSF JurkatGSE13047 77982559 77983592 1033 0
NRSF JurkatGSE13047 78055651 78056724 1073 0
NRSF JurkatGSE13047 78064838 78067211 2373 0
NRSF JurkatGSE13047 78398805 78399948 1143 0
NRSF JurkatGSE13047 78511738 78512279 541 0
NRSF JurkatGSE13047 78697409 78698164 755 0
NRSF JurkatSISSRdata 78399213 78399644 431 0
NRSF JurkatSISSRdata 78511955 78512182 227 0
NRSF mAbJurkat 77938993 77941641 2648 0
NRSF mAbJurkat 77981060 77985062 4002 0
NRSF mAbJurkat 77986037 77986916 879 0
NRSF mAbJurkat 78049020 78058114 9094 0
NRSF mAbJurkat 78059052 78059576 524 0
NRSF mAbJurkat 78059950 78063180 3230 0
NRSF mAbJurkat 78063804 78064828 1024 0
NRSF mAbJurkat 78065186 78068078 2892 0
NRSF mAbJurkat 78068530 78070625 2095 0
NRSF mAbJurkat 78395433 78396655 1222 0
NRSF mAbJurkat 78397622 78400283 2661 0
NRSF mAbJurkat 78401176 78402850 1674 0
NRSF mAbJurkat 78404958 78405825 867 0
NRSF mAbJurkat 78510596 78512127 1531 0
NRSF mAbJurkat 78696040 78698158 2118 0
NRSF mAbJurkat 78698875 78700405 1530 0
NRSF-mono JurkatQuESTdata 77982655 77983581 926 0
NRSF-mono JurkatQuESTdata 78055656 78056882 1226 0
NRSF-mono JurkatQuESTdata 78062179 78062486 307 0
NRSF-mono JurkatQuESTdata 78064993 78065310 317 0
NRSF-mono JurkatQuESTdata 78065984 78066867 883 0
NRSF-mono JurkatQuESTdata 78066883 78067053 170 0
NRSF-mono JurkatQuESTdata 78398862 78400081 1219 0
NRSF-mono JurkatQuESTdata 78511828 78512181 353 0
NRSF-mono JurkatQuESTdata 78697466 78698162 696 0
NRSF-poly JurkatQuESTdata 77982713 77983595 882 0
NRSF-poly JurkatQuESTdata 78055799 78056516 717 0
NRSF-poly JurkatQuESTdata 78056724 78057369 645 0
NRSF-poly JurkatQuESTdata 78059256 78059506 250 0
NRSF-poly JurkatQuESTdata 78065665 78066803 1138 0
NRSF-poly JurkatQuESTdata 78399121 78400020 899 0
NRSF-poly JurkatQuESTdata 78511830 78512179 349 0
NRSF-poly JurkatQuESTdata 78697506 78698187 681 0
NRSF-poly JurkatQuESTdata 78782352 78782732 380 0
Nanog ESGSE20650 78428740 78429463 723 0
Nanog ESGSE20650 78556652 78557086 434 0
Nanog hESGSE18292 78233402 78233771 369 0
Nanog hESGSE18292 78292996 78293283 287 0
Nanog hESGSE18292 78385731 78386279 548 0
Nanog hESGSE18292 78474294 78474512 218 0
Nanog hESGSE18292 78547302 78547495 193 0
Oct1 H2O2-HelaGSE14283 78019386 78019420 34 0
Oct1 H2O2-HelaGSE14283 78047264 78047292 28 0
Oct1 H2O2-HelaGSE14283 78048014 78048042 28 0
Oct1 H2O2-HelaGSE14283 78051270 78051306 36 0
Oct1 H2O2-HelaGSE14283 78106636 78106667 31 0
Oct1 H2O2-HelaGSE14283 78150554 78150586 32 0
Oct1 H2O2-HelaGSE14283 78160323 78160350 27 0
Oct1 H2O2-HelaGSE14283 78206760 78206791 31 0
Oct1 H2O2-HelaGSE14283 78243808 78243839 31 0
Oct1 H2O2-HelaGSE14283 78273748 78273775 27 0
Oct1 H2O2-HelaGSE14283 78296464 78296492 28 0
Oct1 H2O2-HelaGSE14283 78405479 78405509 30 0
Oct1 H2O2-HelaGSE14283 78562942 78562969 27 0
Oct1 H2O2-HelaGSE14283 78815306 78815334 28 0
Oct1 HelaGSE14283 77968363 77968396 33 0
Oct1 HelaGSE14283 77973111 77973139 28 0
Oct1 HelaGSE14283 78019386 78019424 38 0
Oct1 HelaGSE14283 78036461 78036488 27 0
Oct1 HelaGSE14283 78047258 78047292 34 0
Oct1 HelaGSE14283 78051271 78051306 35 0
Oct1 HelaGSE14283 78059331 78059370 39 0
Oct1 HelaGSE14283 78060553 78060582 29 0
Oct1 HelaGSE14283 78081210 78081264 54 0
Oct1 HelaGSE14283 78102015 78102052 37 0
Oct1 HelaGSE14283 78121891 78121920 29 0
Oct1 HelaGSE14283 78122166 78122236 70 0
Oct1 HelaGSE14283 78128536 78128566 30 0
Oct1 HelaGSE14283 78150543 78150591 48 0
Oct1 HelaGSE14283 78154670 78154707 37 0
Oct1 HelaGSE14283 78160318 78160350 32 0
Oct1 HelaGSE14283 78173505 78173536 31 0
Oct1 HelaGSE14283 78184892 78184930 38 0
Oct1 HelaGSE14283 78186353 78186397 44 0
Oct1 HelaGSE14283 78206753 78206827 74 0
Oct1 HelaGSE14283 78220214 78220244 30 0
Oct1 HelaGSE14283 78240032 78240063 31 0
Oct1 HelaGSE14283 78251372 78251404 32 0
Oct1 HelaGSE14283 78296464 78296495 31 0
Oct1 HelaGSE14283 78378513 78378552 39 0
Oct1 HelaGSE14283 78434818 78434846 28 0
Oct1 HelaGSE14283 78510706 78510743 37 0
Oct1 HelaGSE14283 78519312 78519361 49 0
Oct1 HelaGSE14283 78523174 78523223 49 0
Oct1 HelaGSE14283 78524559 78524588 29 0
Oct1 HelaGSE14283 78573223 78573251 28 0
Oct1 HelaGSE14283 78671435 78671495 60 0
Oct1 HelaGSE14283 78815306 78815334 28 0
Oct4 hESGSE21916 78428805 78429239 434 0
P300 T30-glioblastomaGSE21026 78552807 78553422 615 0
RARG MCF7GSE15244 78134066 78134588 522 0
RNAII Tamoxifen-MCF7GSE14664 78051259 78051302 43 0
Rb GrowingGSE19898 78495912 78496103 191 0
Sox2 hESGSE18292 78233565 78233763 198 0
Stat6 IL-4-hr4GSE17850 78290246 78290779 533 0
Stat6 IL-4-hr4GSE17850 78320444 78321010 566 0
TFAP2C MCF7GSE21234 78581419 78581756 337 0
TFAP2C MCF7GSE21234 78613219 78613733 514 0
hScc1 BcellGSE12603 77984599 77984916 317 0
hScc1 BcellGSE12603 78102634 78103016 382 0
hScc1 BcellGSE12603 78133887 78134663 776 0
hScc1 BcellGSE12603 78233376 78233763 387 0
hScc1 BcellGSE12603 78372891 78373266 375 0
hScc1 BcellGSE12603 78470061 78470460 399 0
hScc1 CdLSGSE12603 77984416 77985162 746 0
hScc1 CdLSGSE12603 78102634 78103289 655 0
hScc1 CdLSGSE12603 78133887 78134627 740 0
hScc1 CdLSGSE12603 78233432 78233827 395 0
hScc1 CdLSGSE12603 78372855 78373382 527 0
hScc1 CdLSGSE12603 78470061 78470424 363 0
hScc1 CdLSGSE12603 78547062 78547654 592 0
p63 keratinocytesGSE17611 78547299 78548314 1015 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
8194 mRNA NRXN3 chr14 78815434 79400511 129594 EST chr14 79197765 79327359 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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